Výsledky vyhledávání - "Vehary Sakanyan"

Akademický článek

Targeted Strategies for Degradation of Key Transmembrane Proteins in Cancer

Autor: Vehary Sakanyan, Nina Iradyan, Rodolphe Alves de Sousa

Publikováno v: BioTech, Vol 12, Iss 3, p 57 (2023)

Targeted protein degradation is an attractive technology for cancer treatment due to its ability to overcome the unpredictability of the small molecule inhibitors that cause resistance mutations. In recent years, various targeted protein degradation

Externí odkaz: https://doaj.org/article/4da46726c09b46afb5e379e013fcb943

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Akademický článek

Cell-Free Protein Synthesis by Diversifying Bacterial Transcription Machinery

Autor: Marina Snapyan, Sylvain Robin, Garabet Yeretssian, Michèle Lecocq, Frédéric Marc, Vehary Sakanyan

Publikováno v: BioTech, Vol 10, Iss 4, p 24 (2021)

We have evaluated several approaches to increase protein synthesis in a cell-free coupled bacterial transcription and translation system. A strong pargC promoter, originally isolated from a moderate thermophilic bacterium Geobacillus stearothermophil

Externí odkaz: https://doaj.org/article/ac1970370ea0448ca75424cb9dc972b0

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Cell-Free Protein Synthesis by Diversifying Bacterial Transcription Machinery

Autor: Sylvain Robin, Vehary Sakanyan, Frederic Marc, Garabet Yeretssian, Michèle Lecocq, Marina Snapyan

Publikováno v: BioTech
Volume 10
Issue 4
BioTech, Vol 10, Iss 24, p 24 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b5ab821931f74406d278f034c65437
https://pubmed.ncbi.nlm.nih.gov/35822798

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Rational Engineering of the Substrate Specificity of a Thermostable D-Hydantoinase (Dihydropyrimidinase)

Autor: Vehary Sakanyan, Pierre Weigel, Jean-Noël Hallet, Hovsep Alexandr Aganyants, A. A. Hambardzumyan, Haykanush Koloyan, Yeranuhi Hovhannisyan, Anichka S. Hovsepyan, Michèle Lecocq

Publikováno v: High-Throughput, Vol 9, Iss 1, p 5 (2020)
High-Throughput
Volume 9
Issue 1

D-hydantoinases catalyze an enantioselective opening of 5- and 6-membered cyclic structures and therefore can be used for the production of optically pure precursors for biomedical applications. The thermostable D-hydantoinase from Geobacillus stearo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9813184c02a072a0269bf4d86f8608cc
https://www.mdpi.com/2571-5135/9/1/5

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Targeting Degradation of EGFR through the Allosteric Site Leads to Cancer Cell Detachment-Promoted Death

Autor: Melkon, Iradyan, Nina, Iradyan, Philippe, Hulin, Artur, Hambardzumyan, Aram, Gyulkhandanyan, Rodolphe, Alves de Sousa, Assia, Hessani, Christos, Roussakis, Guillaume, Bollot, Cyril, Bauvais, Vehary, Sakanyan

Publikováno v: Cancers
Cancers, 2019, 11 (8), pp.1094. ⟨10.3390/cancers11081094⟩
Cancers, MDPI, 2019, 11 (8), pp.1094. ⟨10.3390/cancers11081094⟩
Cancers, Vol 11, Iss 8, p 1094 (2019)

Targeting epidermal growth factor receptor (EGFR) with tyrosine kinase inhibitors (TKI) has been widely exploited to disrupt aberrant phosphorylation flux in cancer. However, a bottleneck of potent TKIs is the acquisition of drug resistance mutations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a3c2a60f4fb1f35cfa8feda4f4c16599
https://hal-univ-evry.archives-ouvertes.fr/hal-02321259/document

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Reactive Chemicals and Electrophilic Stress in Cancer

Autor: Vehary Sakanyan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30f60dc474545278c3267ca2e47ed3f3
https://doi.org/10.20944/preprints201803.0028.v1

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Assessment of new cationic porphyrin binding to plasma proteins by planar microarray and spectroscopic methods

Autor: Robert K. Ghazaryan, Vehary Sakanyan, Marie Angelini, Lusine Gyulkhandanyan, Aram G. Gyulkhandanyan, Grigor V. Gyulkhandanyan, Fabrice Fleury

Publikováno v: Journal of Biomolecular Structure and Dynamics. 31:363-375

Porphyrins have a unique aromatic structure determining particular photochemical properties that make them promising photosensitizers for anticancer therapy. Previously, we synthesized a set of artificial porphyrins by modifying side-chain functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1333c076cddd4a70360c9bb201c1c8
https://doi.org/10.1080/07391102.2012.703063

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Reactive Chemicals and Electrophilic Stress in Cancer: A Minireview

Autor: Vehary Sakanyan

Publikováno v: High-Throughput

Exogenous reactive chemicals can impair cellular homeostasis and are often associated with the development of cancer. Significant progress has been achieved by studying the macromolecular interactions of chemicals that possess various electron-withdr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d26212b0250569b53bc5f671ec2a0e8
https://doi.org/10.3390/ht7020012

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Dynamin 2 mutations associated with human diseases impair clathrin-mediated receptor endocytosis

Autor: Norma B. Romero, Adrien Herledan, Jorge A. Bevilacqua, Bernard Prudhon, Pascale Guicheney, Luis Cartier, Vehary Sakanyan, Anne-Cécile Durieux, Andoni Urtizberea, Marc Bitoun

Publikováno v: Human Mutation. 30:1419-1427

Dynamin 2 (DNM2) is a large GTPase involved in the release of nascent vesicles during endocytosis and intracellular membrane trafficking. Distinct DNM2 mutations, affecting the middle domain (MD) and the Pleckstrin homology domain (PH), have been ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f4743069630ac9a1452b89450aa53a
https://doi.org/10.1002/humu.21086

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TP53 transcription factor for the NEDD9/HEF1/Cas-L gene: potential targets in Non-Small Cell Lung Cancer treatment

Autor: Bénédicte Rousseau, Catherine Jacquot, Christos Roussakis, Marine Malleter, Tifenn Boutard, Vehary Sakanyan, Christophe Tomasoni, Julie Le Palabe

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2015, 5 (1), pp.10356. ⟨10.1038/srep10356⟩
Scientific Reports, 2015, 5 (1), pp.10356. ⟨10.1038/srep10356⟩

Lung cancer is a serious public health problem. Although there has been significant progress in chemotherapy, non-small cell lung cancer is still resistant to current treatments, primarily because of the slow rate of cell development. It is thus impo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2da94084f3235efd6ca8d578c803d05
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01165439/document

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