MTCH2 is a conserved regulator of lipid homeostasis

Autor: Yehudit Zaltsman, Siu Sylvia Lee, Michael Platov, Sergiy Libert, Atan Gross, Antonella Ruggiero, Adam B. Francisco, Veerle Rottiers

Publikováno v: Obesity. 25:616-625

Objective More than one-third of U.S. adults have obesity, causing an alarming increase in obesity-related comorbidities such as type 2 diabetes. The functional role of mitochondrial carrier homolog 2 (MTCH2), a human obesity-associated gene, in lipi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2fca231c03dd87179160b89f509b8d1
https://doi.org/10.1002/oby.21751

The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity

Autor: David J. Mangelsdorf, Yidong Shen, Lilia Magomedova, Joshua Wollam, Adam Antebi, Daniel L. Motola, Carolyn L. Cummins, Veerle Rottiers, Daniel B. Magner

Publikováno v: Aging Cell. 10:879-884

Summary Bile acids are cholesterol-derived signaling molecules that regulate mammalian metabolism through sterol-sensing nuclear receptor transcription factors. In C. elegans, bile acid-like steroids called dafachronic acids (DAs) control development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e28d75c71a8a8307dcafdd14fab52cb
https://doi.org/10.1111/j.1474-9726.2011.00733.x

FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development

Autor: Jianrong Lu, Lizi Wu, Yue Jin, Tong Lin, Huangxuan Shen, Miriam Tarrash, Qingsong Cai, Kamal A. Mohammed, Hao Chen, Samuel N. Doernberg, Xin Hu, Huacheng Luo, Siu Sylvia Lee, Ryan Fiske, Anitha K. Shenoy, Veerle Rottiers, Ting Chen

The Snail family of transcription factors are core inducers of epithelial-to-mesenchymal transition (EMT). Here we show that the F-box protein FBXO11 recognizes and promotes ubiquitin-mediated degradation of multiple Snail family members including Sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c61f7e0debc486dac835d5e55c6321
https://europepmc.org/articles/PMC4406488/

Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR

Autor: Anders M. Näär, Steve Henry, Johnathan R. Whetstine, Raymond T. Chung, Robert E. Gerszten, Seyed Hani Najafi-Shoushtari, Robin J Goody, Susanna Obad, Andrew deLemos, Rohn Brookes, Steve Whittaker, Matthew Lawrence, Joshua C. Black, Sumita Sinha, Robert W. McGarrah, Henrik Frydenlund Hansen, Veerle Rottiers, Andreas Petri, Marie Lindholm, Sakari Kauppinen

Publikováno v: Rottiers, V, Obad, S, Petri, A, McGarrah, R, Lindholm, M W, Black, J C, Sinha, S, Goody, R J, Lawrence, M S, Delemos, A S, Hansen, H F, Whittaker, S, Henry, S, Brookes, R, Najafi-Shoushtari, S H, Chung, R T, Whetstine, J R, Gerszten, R E, Kauppinen, S & Näär, A M 2013, ' Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR ', Science Translational Medicine, vol. 5, no. 212, pp. 212ra162 . https://doi.org/10.1126/scitranslmed.3006840

MicroRNAs (miRNAs) regulate many aspects of human biology. They target mRNAs for translational repression or degradation through base-pairing with 3’ UTRs, primarily via seed sequences (nucleotides 2-8 in the mature miRNA sequence). A number of ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aad12278fa954b88f6db17e9a7b5e1a
https://pubmed.ncbi.nlm.nih.gov/24259050

MicroRNAs in Metabolism and Metabolic Disorders

Autor: Veerle Rottiers, Anders M. Näär

MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example, miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb74b4d8289464e7dea195985147ee01
https://europepmc.org/articles/PMC4021399/