Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Veerle Liebens"'
Autor:
Shaunak Khandekar, Veerle Liebens, Maarten Fauvart, Paul M. Tulkens, Jan Michiels, Françoise Van Bambeke
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Persisters are the fraction of antibiotic-exposed bacteria transiently refractory to killing and are recognized as a cause of antibiotic treatment failure. The putative de-N-acetylase DnpA increases persister levels in Pseudomonas aeruginosa upon exp
Externí odkaz:
https://doaj.org/article/7f685cd873f84a84b035c8896e39c9b0
Autor:
Valerie Defraine, Veerle Liebens, Evelien Loos, Toon Swings, Bram Weytjens, Carolina Fierro, Kathleen Marchal, Liam Sharkey, Alex J. O’Neill, Romu Corbau, Arnaud Marchand, Patrick Chaltin, Maarten Fauvart, Jan Michiels
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
The ever increasing multidrug-resistance of clinically important pathogens and the lack of novel antibiotics have resulted in a true antibiotic crisis where many antibiotics are no longer effective. Further complicating the treatment of bacterial inf
Externí odkaz:
https://doaj.org/article/3a312b1dedc148f7bfd3d5bebb78855a
Autor:
Evelien Gerits, Eline Blommaert, Anna Lippell, Alex J O'Neill, Bram Weytjens, Dries De Maeyer, Ana Carolina Fierro, Kathleen Marchal, Arnaud Marchand, Patrick Chaltin, Pieter Spincemaille, Katrijn De Brucker, Karin Thevissen, Bruno P A Cammue, Toon Swings, Veerle Liebens, Maarten Fauvart, Natalie Verstraeten, Jan Michiels
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155139 (2016)
Nosocomial and community-acquired infections caused by multidrug resistant bacteria represent a major human health problem. Thus, there is an urgent need for the development of antibiotics with new modes of action. In this study, we investigated the
Externí odkaz:
https://doaj.org/article/7817d195d5314e5da71bb79f9598c0f1
Autor:
Lenart Girandon, Geert Hooyberghs, Jozef Vanderleyden, Erik V. Van der Eycken, Stijn Robijns, Jan Michiels, Natalie Verstraeten, Hans Steenackers, Nicolas Delattin, Veerle Liebens, Karin Thevissen, Barbara Dovgan, Patrick Van Dijck, Mirjam Fröhlich, Kai Waldrant, Soňa Kucharíková, Elien Peeters, Katrijn De Brucker, Bruno P. A. Cammue, Hélène Tournu, Ami De Weerdt
Publikováno v:
Antimicrobial Agents and Chemotherapy
We previously synthesized several series of compounds, based on the 5-aryl-2-aminoimidazole scaffold, that showed activity preventing the formation of Salmonella enterica serovar Typhimurium and Pseudomonas aeruginosa biofilms. Here, we further studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2712cf0f928850c61832624acb4ce6a
https://doi.org/10.1128/aac.00035-16
https://doi.org/10.1128/aac.00035-16
Autor:
Maarten Fauvart, Shaunak Khandekar, Jan Michiels, Françoise Van Bambeke, Paul M. Tulkens, Veerle Liebens
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Frontiers in Microbiology
Frontiers in Microbiology
Persisters are the fraction of antibiotic-exposed bacteria transiently refractory to killing and are recognized as a cause of antibiotic treatment failure. The putative de-N-acetylase DnpA increases persister levels in Pseudomonas aeruginosa upon exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ecd37433d0cc41ed4544796e9da8631
https://www.frontiersin.org/article/10.3389/fmicb.2018.01455/full
https://www.frontiersin.org/article/10.3389/fmicb.2018.01455/full
Autor:
Valerie Defraine, Veerle Liebens, Evelien Loos, Toon Swings, Bram Weytjens, Carolina Fierro, Kathleen Marchal, Liam Sharkey, Alex J. O’Neill, Romu Corbau, Arnaud Marchand, Patrick Chaltin, Maarten Fauvart, Jan Michiels
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
FRONTIERS IN MICROBIOLOGY
Frontiers in Microbiology
FRONTIERS IN MICROBIOLOGY
Frontiers in Microbiology
The ever increasing multidrug-resistance of clinically important pathogens and the lack of novel antibiotics have resulted in a true antibiotic crisis where many antibiotics are no longer effective. Further complicating the treatment of bacterial inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34654efeedd23d8b0df15eab46d71766
https://lirias.kuleuven.be/handle/123456789/621341
https://lirias.kuleuven.be/handle/123456789/621341
Autor:
Patrick Chaltin, Evelien Gerits, Karin Thevissen, Stijn Robijns, Matija Veber, Veerle Liebens, Jan Michiels, Anna Lippell, Serge Beullens, Natalie Verstraeten, Maria Lövenklev, Toon Swings, Maarten Fauvart, Alex J. O'Neill, Bruno P. A. Cammue, Annika Krona, Romu Corbau, Wouter Knapen, Katrijn De Brucker, Mirjam Fröhlich, Hans Steenackers, Arnaud Marchand
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5404-5408
Pseudomonas aeruginosa strains resistant towards all currently available antibiotics are increasingly encountered, raising the need for new anti-pseudomonal drugs. We therefore conducted a medium-throughput screen of a small-molecule collection resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c89d97f37e5f56cad28111ec335a49d
https://doi.org/10.1016/j.bmcl.2014.10.039
https://doi.org/10.1016/j.bmcl.2014.10.039
Autor:
Patrick Chaltin, Valerie Defraine, Veerle Liebens, Toon Swings, Romu Corbau, Wouter Knapen, Arnaud Marchand, Jan Michiels, Serge Beullens, Maarten Fauvart
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Antibiotics typically fail to completely eradicate a bacterial population, leaving a small fraction of transiently antibiotic-tolerant persister cells intact. Persisters are therefore seen to be a major cause of treatment failure and greatly contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f5980afe2bedf9e79a3d96bd4ec03e
https://doi.org/10.1128/aac.00836-17
https://doi.org/10.1128/aac.00836-17
Autor:
Julio Collado-Vides, Pieter Meysman, Paolo Sonego, Qiang Fu, Socorro Gama-Castro, Kathleen Marchal, Luca Bianco, Jan Michiels, Kristof Engelen, Veerle Liebens, Daniela Ledezma-Tejeida, Kris Laukens
Publikováno v:
Nucleic Acids Research. 42:D649-D653
The COLOMBOS database (http://www.colombos.net) features comprehensive organism-specific cross-platform gene expression compendia of several bacterial model organisms and is supported by a fully interactive web portal and an extensive web API. COLOMB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6af662bb2889465f9596677758b0c94e
https://doi.org/10.1093/nar/gkt1086
https://doi.org/10.1093/nar/gkt1086
Publikováno v:
Methods in Molecular Biology ISBN: 9781493928538
Despite its clinical relevance and the fact that the phenomenon of persistence was discovered in the 1940s, little is known about the mechanisms behind persister cell formation. Research in this field has mainly focused on the model organism Escheric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::848089549daf46747ff3cf55098bb7c4
https://doi.org/10.1007/978-1-4939-2854-5_10
https://doi.org/10.1007/978-1-4939-2854-5_10