Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Veerle Geurts"'
Autor:
Adriana Martinez-Silgado, Fjodor A. Yousef Yengej, Jens Puschhof, Veerle Geurts, Charelle Boot, Maarten H. Geurts, Maarten B. Rookmaaker, Marianne C. Verhaar, Joep Beumer, Hans Clevers
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101639- (2022)
Summary: Intestinal organoids are three-dimensional cultures that resemble key aspects of the epithelium of origin. Here, we describe how to differentiate human small intestinal organoids by combining growth media variations and genetic engineering.
Externí odkaz:
https://doaj.org/article/dcf1297473074b90b8864176f730bcd6
Autor:
Veerle Geurts, Marleen Kok
Publikováno v:
Current Treatment Options in Oncology. 24:628-643
Opinion statementIn approximately 15–20% of the patients diagnosed with breast cancer, it comprises the triple negative (TN) subtype, which until recently lacked targets for specific treatments and is known for its aggressive clinical behavior in p
Autor:
Veerle Geurts, Leonie Voorwerk, Karolina Sikorska, Roberto Salgado, Koen van de Vijver, Marloes van Dongen, Inge Kemper, Ingrid A. Mandjes, Martine Heuver-mes, John Haanen, Gabe S. Sonke, Hugo Horlings, Marleen Kok
Publikováno v:
Cancer Research. 83:P3-06
Background Although treatment options and survival of HER2+ metastatic breast cancer (MBC) patients have greatly improved, the majority of MBC-patients still die of this disease. The relatively high levels of TILs observed in this BC subtype provide
Autor:
Hans Clevers, Alexander van Oudenaarden, Peter J. Peters, David A. Tuveson, Geert J.P.L. Kops, Ruben van Boxtel, Onno Kranenburg, Priya Sridevi, Nino Iakobachvili, Antoni P.A. Hendrickx, Maurice M.J.M. Zandvliet, Judith Vivié, Mauro J. Muraro, Rurika Oka, Richard H. van Jaarsveld, Gui-Wei He, Veerle Geurts, Johan H. van Es, Harry Begthel, Jeroen Korving, Emma J. de Ruiter, Remco de Bree, Lot A. Devriese, Stefan M. Willems, Kadi Lõhmussaar, Sacha Spelier, Sigrid Kolders, Else Driehuis
Movie S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0841e5cc268c6b6638bd8b10df5c249
https://doi.org/10.1158/2159-8290.22536523
https://doi.org/10.1158/2159-8290.22536523
Autor:
Hans Clevers, Alexander van Oudenaarden, Peter J. Peters, David A. Tuveson, Geert J.P.L. Kops, Ruben van Boxtel, Onno Kranenburg, Priya Sridevi, Nino Iakobachvili, Antoni P.A. Hendrickx, Maurice M.J.M. Zandvliet, Judith Vivié, Mauro J. Muraro, Rurika Oka, Richard H. van Jaarsveld, Gui-Wei He, Veerle Geurts, Johan H. van Es, Harry Begthel, Jeroen Korving, Emma J. de Ruiter, Remco de Bree, Lot A. Devriese, Stefan M. Willems, Kadi Lõhmussaar, Sacha Spelier, Sigrid Kolders, Else Driehuis
Previous studies have described that tumor organoids can capture the diversity of defined human carcinoma types. Here, we describe conditions for long-term culture of human mucosal organoids. Using this protocol, a panel of 31 head and neck squamous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5e4c06e92aae2c945d53df37939ee42
https://doi.org/10.1158/2159-8290.c.6548158.v1
https://doi.org/10.1158/2159-8290.c.6548158.v1
Autor:
Hans Clevers, Alexander van Oudenaarden, Peter J. Peters, David A. Tuveson, Geert J.P.L. Kops, Ruben van Boxtel, Onno Kranenburg, Priya Sridevi, Nino Iakobachvili, Antoni P.A. Hendrickx, Maurice M.J.M. Zandvliet, Judith Vivié, Mauro J. Muraro, Rurika Oka, Richard H. van Jaarsveld, Gui-Wei He, Veerle Geurts, Johan H. van Es, Harry Begthel, Jeroen Korving, Emma J. de Ruiter, Remco de Bree, Lot A. Devriese, Stefan M. Willems, Kadi Lõhmussaar, Sacha Spelier, Sigrid Kolders, Else Driehuis
Supplementary Figures including legends, Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394d1f1adbede503e7e8e1180ac1bfbe
https://doi.org/10.1158/2159-8290.22536505.v1
https://doi.org/10.1158/2159-8290.22536505.v1
Autor:
Bastiaan Viergever, Daniëlle Raats, Veerle Geurts, Jasper Mullenders, Trudy Jonges, Michiel (S.) Van der Heijden, Johan van Es, Onno Kranenburg, Richard Meijer
Bladder cancer is one of the most common cancer-types worldwide. Generally, research relies on invasive sampling strategies. Here, we generate bladder cancer organoids directly from urine (urinoids). In this project, we establish 12 urinoid-lines fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23c4e069928b2cede7cd70fb0cf0685d
https://doi.org/10.21203/rs.3.rs-2499089/v1
https://doi.org/10.21203/rs.3.rs-2499089/v1
Autor:
Joep Beumer, Julia Bauzá-Martinez, Tim S. Veth, Veerle Geurts, Charelle Boot, Hannah Gilliam-Vigh, Steen S. Poulsen, Filip K. Knop, Wei Wu, Hans Clevers
Publikováno v:
Beumer, J, Bauzá-Martinez, J, Veth, T S, Geurts, V, Boot, C, Gilliam-Vigh, H, Poulsen, S S, Knop, F K, Wu, W & Clevers, H 2022, ' Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 46, e2212057119 . https://doi.org/10.1073/pnas.2212057119
Proceedings of the National Academy of Sciences of the United States of America, 119(46). National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 119(46). National Academy of Sciences
Enteroendocrine cells (EECs) secrete hormones in response to ingested nutrients to control physiological processes such as appetite and insulin release. EEC hormones are synthesized as large proproteins that undergo proteolytic processing to generate
Autor:
Joep Beumer, Veerle Geurts, Stieneke van den Brink, Jens Puschhof, Hans Clevers, Cayetano Pleguezuelos-Manzano
Publikováno v:
Current protocols in immunology, 130(1)
Current Protocols in Immunology
Current Protocols in Immunology
Human intestinal organoids derived from adult stem cells are miniature ex vivo versions of the human intestinal epithelium. Intestinal organoids are useful tools for the study of intestinal physiology as well as many disease conditions. These organoi
Autor:
Mathew J. Garnett, Else Driehuis, Arne Van Hoeck, Johan H. van Es, Hayley E. Francies, Lodewijk A.A. Brosens, Veerle Geurts, Robert P. de Vries, Sigrid Kolders, Lodewyk F. A. Wessels, Boudewijn M.T. Burgering, Kat Moore, Gergana Bounova, Sylvia F. Boj, Folkert H.M. Morsink, Edwin C. A. Stigter, Hans Clevers, Edwin Cuppen, G. Johan A. Offerhaus, Onno Kranenburg, M. Can Gulersonmez, Ana Gracanin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
We report the derivation of 30 patient-derived organoid lines (PDOs) from tumors arising in the pancreas and distal bile duct. PDOs recapitulate tumor histology and contain genetic alterations typical of pancreatic cancer. In vitro testing of a panel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdec23c70add841eb5de1cc9e19bb429
https://pure.knaw.nl/portal/en/publications/4db45fba-cb9b-4424-af43-7e2cd39f18e4
https://pure.knaw.nl/portal/en/publications/4db45fba-cb9b-4424-af43-7e2cd39f18e4