N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line

Autor: Theresa Kissel, Veerle F. A. M. Derksen, Arthur E. H. Bentlage, Carolien Koeleman, Lise Hafkenscheid, Diane van der Woude, Manfred Wuhrer, Gestur Vidarsson, René E. M. Toes

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract IgG secreted by B cells carry asparagine N(297)-linked glycans in the fragment crystallizable (Fc) region. Changes in Fc glycosylation are related to health or disease and are functionally relevant, as IgG without Fc glycans cannot bind to F

Externí odkaz: https://doaj.org/article/93a8586e551741e0bef6fe5c6e66c9f0

In rheumatoid arthritis, changes in autoantibody levels reflect intensity of immunosuppression, not subsequent treatment response

Autor: Emma C. de Moel, Veerle F. A. M. Derksen, Leendert A. Trouw, Holger Bang, Gerard Collée, Leroy R. Lard, Sofia Ramiro, Tom W. J. Huizinga, Cornelia F. Allaart, René E. M. Toes, Diane van der Woude

Publikováno v: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-8 (2019)

Abstract Background Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies like rheumatoid factor (RF), anti-cyclic citrullinated peptide-2 (anti-CCP2), and anti-carbamylated protein (anti-CarP) antibodies. It is currently uncle

Externí odkaz: https://doaj.org/article/d3b08a3b716a42cc9ab670e45e1d74b9

The isotype and IgG subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients

Autor: Myrthe A. M. van Delft, Marije K. Verheul, Leonie E. Burgers, Veerle F. A. M. Derksen, Annette H. M. van der Helm-van Mil, Diane van der Woude, Tom W. J. Huizinga, René E. M. Toes, Leendert A. Trouw

Publikováno v: Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-12 (2017)

Abstract Background Anti-carbamylated protein (anti-CarP) antibodies have recently been reported to occur in around 45% of rheumatoid arthritis (RA) patients and to have prognostic and diagnostic properties. At present, the breadth and molecular make

Externí odkaz: https://doaj.org/article/643acd4a72964145a09222c0ccdb809e

Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load

Autor: Veerle F. A. M. Derksen, Theo Rispens, Holger Bang, Jan W. Drijfhout, Pleuni Ooijevaar-de Heer, Sanne Reijm, René E. M. Toes, Nivine E. W. Levarht, Hans Scherer, Leendert A. Trouw, Gerrie Stoeken-Rijsbergen, Corrie M. Wortel, Tom W J Huizinga, Linda M. Slot, Hugo J. van Dooren, Arieke S. B. Kampstra, Theresa Kissel

Publikováno v: Arthritis Research and Therapy, 23(1). BMC
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)

Background Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although AMPA-IgG cross-reactivity to multiple post-translational modifications (PTMs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1502e82abff52ec3d8523d897b4f25
https://hdl.handle.net/1887/3240261

In rheumatoid arthritis, changes in autoantibody levels reflect intensity of immunosuppression, not subsequent treatment response

Autor: Tom W J Huizinga, LR Lard, Holger Bang, Veerle F. A. M. Derksen, Gerard Collée, René E. M. Toes, Diane van der Woude, Sofia Ramiro, Cornelia F Allaart, Leendert A. Trouw, Emma C. de Moel

Publikováno v: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-8 (2019)
Arthritis Research and Therapy, 21
Arthritis Research & Therapy
Arthritis Research and Therapy

Background Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies like rheumatoid factor (RF), anti-cyclic citrullinated peptide-2 (anti-CCP2), and anti-carbamylated protein (anti-CarP) antibodies. It is currently unclear whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d17f943dd40d615c07d51d26f5ea06e
https://doi.org/10.1186/s13075-019-1815-0