Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Veerle, Janssens"'
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Glioblastoma (GBM) is the most common primary brain tumor in adults. Current standard therapy is surgery followed by radiotherapy, with concurrent and adjuvant temozolomide chemotherapy. GBM is characterized by almost uniformly fatal outcome
Externí odkaz:
https://doaj.org/article/d4fbc212ea2444e7a35eaf817b0d42f4
Autor:
Jos van Pelt, Bob Meeusen, Rita Derua, Liesbeth Guffens, Eric Van Cutsem, Veerle Janssens, Chris Verslype
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-20 (2023)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) has a low survival, its incidence is rising and little therapeutic improvements are expected in the near future. It has been observed that Epithelial-to-Mesenchymal transition (EMT) contribu
Externí odkaz:
https://doaj.org/article/62e9bee916614108bb722b3a189cf40e
Autor:
Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A. Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Abankwa, Maja Köhn, Vesa P. Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Tumour suppressors are inhibited in cancers and their reactivation could provide novel therapy opportunities. Here, the authors study the structural mechanism by which human tumour suppressor Protein Phosphatase 2A is inhibited in breast cancer cells
Externí odkaz:
https://doaj.org/article/a40d0289287e4365ac202e20daf82ec2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/117ee63d6c554cb59c8e292751202122
Autor:
Iris Verbinnen, Sara S. Procknow, Lisa Lenaerts, Sara Reynhout, Aujan Mehregan, Chris Ulens, Veerle Janssens, Katherine A. King
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
PP2A-related (neuro) developmental disorders are a family of genetic diseases caused by a heterozygous alteration in one of several genes encoding a subunit of type 2A protein phosphatases. Reported affected genes, so far, are PPP2R5D, encoding the P
Externí odkaz:
https://doaj.org/article/2d623b682c10495e8eb5dbcf0c3502dc
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Reversible protein phosphorylation is a fundamental regulation mechanism in eukaryotic cell and organismal physiology, and in human health and disease. Until recently, and unlike protein kinases, mutations in serine/threonine protein phosphatases (PS
Externí odkaz:
https://doaj.org/article/652110a7a8294a96a5e2363b2d0a43ea
Autor:
Kerstin Schott, Nina V. Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Janna Seifried, Christiane Tondera, Heike Schmitz, Caitlin Shepard, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Andreas Reuter, Baek Kim, Veerle Janssens, Renate König
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
SAMHD1 is a critical restriction factor for HIV-1 and its antiviral activity is regulated by T592 phosphorylation. Here, Schott et al. show that the phosphatase PP2A-B55α dephosphorylates SAMHD1 during mitotic exit, rendering it antivirally active i
Externí odkaz:
https://doaj.org/article/3b8f796c4d5d4e31b78e854d8aab59b2
Autor:
Emanuela E. Cortesi, Bob Meeusen, Arno Vanstapel, Stijn E. Verleden, Bart M. Vanaudenaerde, Wim A. Wuyts, Wim Janssens, Veerle Janssens, Tania Roskams, Juan-José Ventura
Publikováno v:
Cells, Vol 10, Iss 12, p 3437 (2021)
Chronic lung diseases (CLDs) represent a set of disorders characterized by the progressive loss of proper lung function. Among severe CLDs, the incidence of chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) has grow
Externí odkaz:
https://doaj.org/article/c23bf2c6d25f4a718da2bc72107efb94
Autor:
Nora Oyama, Pieter Vaneynde, Sara Reynhout, Emily M Pao, Andrew Timms, Xiao Fan, Kimberly Foss, Rita Derua, Veerle Janssens, Wendy Chung, Ghayda M Mirzaa
Publikováno v:
Journal of Medical Genetics. 60:511-522
BackgroundVariants inPPP2R5D, affecting the regulatory B56δ subunit of protein phosphatase 2A (PP2A), have been identified in individuals with neurodevelopmental abnormalities. However, the molecular and clinical spectra remain incompletely understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d0f277faba8420d7cdd77ee32a5f116
https://doi.org/10.1136/jmg-2022-108713
https://doi.org/10.1136/jmg-2022-108713
Autor:
Ken Peeters, Frederik Van Leemputte, Baptiste Fischer, Beatriz M. Bonini, Hector Quezada, Maksym Tsytlonok, Dorien Haesen, Ward Vanthienen, Nuno Bernardes, Carmen Bravo Gonzalez-Blas, Veerle Janssens, Peter Tompa, Wim Versées, Johan M. Thevelein
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Yeast and cancer cells both favor sugar fermentation in aerobic conditions. Here the authors describe a conserved mechanism from yeast to mammals where the glycolysis intermediate fructose-1,6-bisphosphate binds Cdc25/Sos1 and couples increased glyco
Externí odkaz:
https://doaj.org/article/d62a394b1ae143ca9a071cacf8de2008