Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Veerle, Baekelandt"'
Autor:
Veerle Baekelandt
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/92c96f9ba25a4b9f807701de4fea22b6
Autor:
Lennart Höfs, David Geißler-Lösch, Kristof M. Wunderlich, Eva M. Szegö, Chris Van den Haute, Veerle Baekelandt, Wolfgang Hoyer, Björn H. Falkenburger
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 756 (2024)
Aggregation of the protein α-Synuclein (αSyn) is a hallmark of Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple systems atrophy, and alleviating the extent of αSyn pathology is an attractive strategy against neurodegenerati
Externí odkaz:
https://doaj.org/article/56e384f27b224c169fcf2c4f39ceedc3
Autor:
Elżbieta Kania, Jaclyn S. Long, David G. McEwan, Kirsten Welkenhuyzen, Rita La Rovere, Tomas Luyten, John Halpin, Evy Lobbestael, Veerle Baekelandt, Geert Bultynck, Kevin M. Ryan, Jan B. Parys
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-14 (2023)
Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson’s disease (PD), with growing importance also for Crohn’s disease and cancer. LRRK2 is a large and complex protein possessing both G
Externí odkaz:
https://doaj.org/article/ac990b44ebe440e7985118a7bf10125c
Autor:
Julia Obergasteiger, Anne-Marie Castonguay, Sara Pizzi, Stefano Magnabosco, Giulia Frapporti, Evy Lobbestael, Veerle Baekelandt, Andrew A. Hicks, Peter P. Pramstaller, Claude Gravel, Corrado Corti, Martin Lévesque, Mattia Volta
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-17 (2023)
Abstract In Parkinson’s disease (PD) misfolded alpha-synuclein (aSyn) accumulates in the substantia nigra, where dopaminergic neurons are progressively lost. The mechanisms underlying aSyn pathology are still unclear, but they are hypothesized to i
Externí odkaz:
https://doaj.org/article/2734d2239ceb4cf194df390ed133d7c4
Autor:
George Tsafaras, Veerle Baekelandt
Publikováno v:
Neurobiology of Disease, Vol 172, Iss , Pp 105806- (2022)
Parkinson's disease (PD) is currently considered a multisystemic disorder rather than a pure brain disease, in line with the multiple hit hypothesis from Braak. However, despite increasing evidence that the pathology might originate in the periphery,
Externí odkaz:
https://doaj.org/article/eba46c4d1f114bdaaf0948dbcefb04e3
Autor:
Sarah van Veen, Antria Kourti, Elke Ausloos, Joris Van Asselberghs, Chris Van den Haute, Veerle Baekelandt, Jan Eggermont, Peter Vangheluwe
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 918 (2023)
Polyamine homeostasis is disturbed in several human diseases, including cancer, which is hallmarked by increased intracellular polyamine levels and an upregulated polyamine transport system (PTS). Thus far, the polyamine transporters contributing to
Externí odkaz:
https://doaj.org/article/c388195df7a543198aeca36dd9193152
Autor:
Benjamin M. Davis, Li Guo, Nivedita Ravindran, Ehtesham Shamsher, Veerle Baekelandt, Hannah Mitchell, Anil A. Bharath, Lies De Groef, M. Francesca Cordeiro
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Identifying disease-specific patterns of retinal cell loss in pathological conditions has been highlighted by the emergence of techniques such as Detection of Apoptotic Retinal Cells and Adaptive Optics confocal Scanning Laser Ophthalmoscopy
Externí odkaz:
https://doaj.org/article/08eac2c76a8646a3ae3dcc3c2431dae3
Autor:
Matthieu Drouyer, Marc F. Bolliger, Evy Lobbestael, Chris Van den Haute, Marco Emanuele, Réginald Lefebvre, William Sibran, Tina De Wit, Coline Leghay, Eugénie Mutez, Nicolas Dzamko, Glenda M. Halliday, Shigeo Murayama, Alain Martoriati, Katia Cailliau, Jean-François Bodart, Marie-Christine Chartier-Harlin, Veerle Baekelandt, R. Jeremy Nichols, Jean-Marc Taymans
Publikováno v:
Neurobiology of Disease, Vol 157, Iss , Pp 105426- (2021)
LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD). Dephosphorylation at LRRK2's S910/S935/S955/S973 phosphosite cluster is observed in several con
Externí odkaz:
https://doaj.org/article/1fd99d9a1cef4426b7f99882df3c1bd9
Autor:
Teresa Torre-Muruzabal, Jens Devoght, Chris Van den Haute, Bert Brône, Anke Van der Perren, Veerle Baekelandt
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Aggregation of alpha-synuclein (α-SYN) is the pathological hallmark of several diseases named synucleinopathies, including Parkinson’s disease (PD), which is the most common neurodegenerative motor disorder. Alpha-SYN has been linked to s
Externí odkaz:
https://doaj.org/article/ee9667357d7a4b86a024f288d7823213
Autor:
Wouter Peelaerts, Gabriela Mercado, Sonia George, Marie Villumsen, Alysa Kasen, Miguel Aguileta, Christian Linstow, Alexandra B. Sutter, Emily Kuhn, Lucas Stetzik, Rachel Sheridan, Liza Bergkvist, Lindsay Meyerdirk, Allison Lindqvist, Martha L. Escobar Gavis, Chris Van den Haute, Scott J. Hultgren, Veerle Baekelandt, J. Andrew Pospisilik, Tomasz Brudek, Susana Aznar, Jennifer A. Steiner, Michael X. Henderson, Lena Brundin, Magdalena I. Ivanova, Tom J. Hannan, Patrik Brundin
Publikováno v:
Acta Neuropathologica. 145:541-559
Symptoms in the urogenital organs are common in multiple system atrophy (MSA), also in the years preceding the MSA diagnosis. It is unknown how MSA is triggered and these observations in prodromal MSA led us to hypothesize that synucleinopathy could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8e06332a93b1806d5f43f520590e9c
https://doi.org/10.1007/s00401-023-02562-4
https://doi.org/10.1007/s00401-023-02562-4