PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity

Autor: Joshua E, Logan, Nikayeh, Mostofizadeh, Amrita J, Desai, Erika, VON Euw, Dylan, Conklin, Veerauo, Konkankit, Habib, Hamidi, Mark, Eckardt, Lee, Anderson, Hsiao-Wang, Chen, Charles, Ginther, Eileen, Taschereau, Peter H, Bui, James G, Christensen, Arie S, Belldegrun, Dennis J, Slamon, Fairooz F, Kabbinavar

Publikováno v: Anticancer research. 33(8)

PD-0332991 is an inhibitor of cyclin-dependent kinases (CDK) 4 and 6, and was evaluated to determine its anti-proliferative effects in 25 renal cell carcinoma (RCC) cell lines.Half-maximal inhibitory concentrations (IC50) of PD-0332991 were determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9107cb06b5351d821d6aa65375f283fc
https://pubmed.ncbi.nlm.nih.gov/23898052

Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas ligand pathway

Autor: Ascia Eskin, Veerauo Konkankit, Antoni Ribas, Stanley F. Nelson, Won Kim, Mai-Anh Dam, Robert M. Prins, Linda M. Liau, Richard C. Koya

Publikováno v: Journal of Translational Medicine
Journal of Translational Medicine, Vol 9, Iss 1, p 192 (2011)
Konkankit, Veerauo V; Kim, Won; Koya, Richard C; Eskin, Ascia; Dam, Mai-Anh; Nelson, Stanley; et al.(2011). Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas Ligand pathway. Journal of Translational Medicine, 9(1), 192. doi: http://dx.doi.org/10.1186/1479-5876-9-192. Retrieved from: http://www.escholarship.org/uc/item/4131f93b

Background The lack of effective treatments for gliomas makes them a significant health problem and highlights the need for the development of novel and innovative treatment approaches. Immunotherapy is an appealing strategy because of the potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902f11e466022d1ee13ce8b6686b5f1e
https://pubmed.ncbi.nlm.nih.gov/22060015

Molecular profiling and comparative genomic hybridization analysis in human melanoma cell lines and identification of BRAF amplification in a PLX4032 acquired resistance cell line

Autor: Hsiao-Wang Cheng, Charles Ginther, Dennis J. Slamon, Lee Anderson, Erika von Euw, Richard S. Finn, Judy Dering, Veerauo Konkankit, Ke Wei Gong

Publikováno v: Journal of Clinical Oncology. 30:8592-8592

8592 Background: Melanoma is the most aggressive form of skin cancer. Its management is evolving rapidly due to an improved understanding of the molecular heterogeneity and the development of effective, personalized targeted therapies. PLX4032 is a B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88c56fbc173a4426e628dc4b3cf03f86
https://doi.org/10.1200/jco.2012.30.15_suppl.8592