Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Veena Reballi"'
Autor:
Veena Reballi, Jagadeesh Babu Thentu, Vijay Benade, Ramakrishna Nirogi, Nageswara Rao Muddana, Abdul Rasheed Mohammed, Ramkumar Subramanian, Sravanthi Manchineella, Narendra Kagita, Rajesh Kumar Badange, Kumar Bojja, Raghava Choudary Palacharla, Sivasekhar Yarra, Pradeep Jayarajan, Shinde Anil Karbhari, Pramod Kumar Achanta, Bujji Babu Lingavarapu, Mallikarjuna Rao Doguparthi
Publikováno v:
ChemMedChem. 17
A series of chemical optimizations, which was guided by in vitro affinity at histamine H3 receptor (H3 R), modulation of lipophilicity, ADME properties and preclinical efficacy resulted in the identification of 1-[2-(1-cyclobutylpiperidin-4-yloxy)-6,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b45baa35dad5d12cb26ccb67e3120bae
https://doi.org/10.1002/cmdc.202100583
https://doi.org/10.1002/cmdc.202100583
Autor:
Anil Karbhari, Shinde, Rajesh Kumar, Badange, Veena, Reballi, Pramod Kumar, Achanta, Kumar, Bojja, Sravanthi, Manchineella, Nageswara, Rao Muddana, Ramkumar, Subramanian, Raghava, Choudary Palacharla, Vijay, Benade, Pradeep, Jayarajan, Jagadeesh Babu, Thentu, Bujji Babu, Lingavarapu, Sivasekhar, Yarra, Narendra, Kagita, Mallikarjuna, Rao Doguparthi, Abdul Rasheed, Mohammed, Ramakrishna, Nirogi
Publikováno v:
ChemMedChem. 17(3)
A series of chemical optimizations, which was guided by in vitro affinity at histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8035e1a57d85d002ae19d05e8bc1c52
https://pubmed.ncbi.nlm.nih.gov/34761873
https://pubmed.ncbi.nlm.nih.gov/34761873
0265 Samelisant (SUVN-G3031), a Histamine H3 Receptor Inverse Agonist in Animal Models of Narcolepsy
Autor:
Vijay Benade, Renny Abraham, Raghava Chowdary Palacharla, Jagadeesh Babu Thentu, Surendra Petlu, Venkat Reddy Mekala, Santosh Kumar Pandey, Rajesh Kumar Badange, Kumar Bojja, Veena Reballi, Pramod Kumar Achanta, Praveen kumar Choudakari, Ramakrishna Nirogi
Publikováno v:
Sleep. 45:A119-A120
Introduction Samelisant (SUVN-G3031) is a potent and selective H3 receptor (H3R) inverse agonist with hKi of 8.7 nM. It lacks measurable affinity against 70 other targets which includes GPCRs, ion channels, transporters, enzymes, peptides, steroids,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8289b9c80733e9f562a7f1b40e9e7d30
https://doi.org/10.1093/sleep/zsac079.263
https://doi.org/10.1093/sleep/zsac079.263
Autor:
Kiran Kumar Kandukuri, Anil Shinde, Santoshkumar Pandey, Thrinath Reddy Bandyala, Abdul Rasheed Mohammed, Raghava Choudary Palacharla, Ramkumar Subramanian, Kumar Bojja, Sravanthi Manchineella, Pramod Kumar Achanta, Sangram Keshari Saraf, Venkat Jasti, Ramakrishna Nirogi, Rajesh Kumar Badange, Pradeep Jayarajan, Vijay Benade, Veena Reballi
Publikováno v:
Journal of Medicinal Chemistry. 62:1203-1217
A series of chemical optimizations guided by in vitro affinity at a histamine H3 receptor (H3R), physicochemical properties, and pharmacokinetics in rats resulted in identification of N-[4-(1-cyclobutyl-piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a6a6e9590419cd78629224ee0312c10
https://doi.org/10.1021/acs.jmedchem.8b01280
https://doi.org/10.1021/acs.jmedchem.8b01280
Autor:
Ramakrishna Nirogi, Pradeep Jayarajan, Veena Reballi, Venkatesh Kamuju, Sudhakar Gandipudi, Venkata Ramalingayya Grandhi, Jayaprakash Tadiparthi, Rajesh Babu Medapati, Narender Ganuga
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::700e742cce9d4a967085f3d54d20093c
https://doi.org/10.1002/alz.039312
https://doi.org/10.1002/alz.039312
Autor:
Vinod Kumar Goyal, Nageswara Rao Muddana, Veena Reballi, Venkat Reddy Mekala, Jayaprakash Tadiparthi, Maheswari Srirangavaram, Ramakrishna Nirogi, Veera Raghava Chowdary Palacharla, Narender Ganuga, Kumar Bojja, Santosh Kumar Pandey, Rajesh Kumar Badange, Venkata Ramalingayya Grandhi, Pradeep Jayarajan, Rajesh Babu Medapati, Renny Abraham, Gopinadh Bhyrapuneni, Venkatesh Goura
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::900e7015558e589ffb2b8423fea3ea0c
https://doi.org/10.1002/alz.039288
https://doi.org/10.1002/alz.039288
Autor:
Sangram Keshari Saraf, Vinod Kumar Goyal, Ramkumar Subramanian, Rama Sastry Kambhampati, Venugopalarao Bhatta, Abdul Rasheed Mohammed, Ramakrishna Nirogi, Thrinath Reddy Bandyala, Gopinadh Bhyrapuneni, Rajesh Kumar Badange, Raghava Choudary Palacharla, Kumar Bojja, Venkat Jasti, Veena Reballi, Vijay Benade, Pradeep Jayarajan, Anil Shinde
Publikováno v:
Journal of Medicinal Chemistry. 60:1843-1859
Optimization of a novel series of 3-(piperazinylmethyl) indole derivatives as 5-hydroxytryptamine-6 receptor (5-HT6R) antagonists resulted in identification of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd524b552dd775bcb94861bf46741193
https://doi.org/10.1021/acs.jmedchem.6b01662
https://doi.org/10.1021/acs.jmedchem.6b01662
Autor:
Ramakrishna, Nirogi, Anil, Shinde, Abdul Rasheed, Mohammed, Rajesh Kumar, Badange, Veena, Reballi, Thrinath Reddy, Bandyala, Sangram Keshari, Saraf, Kumar, Bojja, Sravanthi, Manchineella, Pramod Kumar, Achanta, Kiran Kumar, Kandukuri, Ramkumar, Subramanian, Vijay, Benade, Raghava Choudary, Palacharla, Pradeep, Jayarajan, Santoshkumar, Pandey, Venkat, Jasti
Publikováno v:
Journal of medicinal chemistry. 62(3)
A series of chemical optimizations guided by in vitro affinity at a histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3bc504790aa828f322e741792955470
https://pubmed.ncbi.nlm.nih.gov/30629436
https://pubmed.ncbi.nlm.nih.gov/30629436
Autor:
Parusharamulu Molgara, Saivishal Daripelli, Nageswararao Muddana, Ramakrishna Nirogi, Pradeep Jayarajan, Veena Reballi, Pramod Kumar Achanta, Venkat Reddy Mekala
Publikováno v:
Sleep. 44:A2-A2
Introduction Narcolepsy is a chronic sleep disorder characterized by overwhelming daytime drowsiness, sudden attacks of sleep and sometimes accompanied by cataplexy. Although the orexin deficiency is considered to be the primary cause of this disorde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b72eab0644e783311b450a1483ff0d5
https://doi.org/10.1093/sleep/zsab072.004
https://doi.org/10.1093/sleep/zsab072.004
Publikováno v:
Asian Journal of Chemistry. 27:2117-2124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bf275c2bb182e647168256a1ae9f6eb
https://doi.org/10.14233/ajchem.2015.17783
https://doi.org/10.14233/ajchem.2015.17783