Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Veena Padmanaban"'
Autor:
Kuppusamy Balamurugan, Dipak K. Poria, Saadiya W. Sehareen, Savitri Krishnamurthy, Wei Tang, Lois McKennett, Veena Padmanaban, Kelli Czarra, Andrew J. Ewald, Naoto T. Ueno, Stefan Ambs, Shikha Sharan, Esta Sterneck
Publikováno v:
JCI Insight, Vol 8, Iss 6 (2023)
Metastatic progression of epithelial cancers can be associated with epithelial-mesenchymal transition (EMT) including transcriptional inhibition of E-cadherin (CDH1) expression. Recently, EM plasticity (EMP) and E-cadherin–mediated, cluster-based m
Externí odkaz:
https://doaj.org/article/502009f78c0b40278ce52d20abc8b4b1
Autor:
Akshay Narkar, Blake A. Johnson, Pandurang Bharne, Jin Zhu, Veena Padmanaban, Debojyoti Biswas, Andrew Fraser, Pablo A. Iglesias, Andrew J. Ewald, Rong Li
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108892- (2021)
Summary: Most solid tumors are aneuploid, and p53 has been implicated as the guardian of the euploid genome. Previous experiments using human cell lines showed that aneuploidy induction leads to p53 accumulation and p21-mediated G1 cell cycle arrest.
Externí odkaz:
https://doaj.org/article/b6e90634dd1e41f39d722a8119491378
Autor:
Elizabeth Jaffee, Isaac Chan, Hildur Knútsdóttir, Gayathri Ramakrishnan, Veena Padmanaban, Manisha Warrier, Juan Carlos Ramirez, Joel Bader, Andrew Ewald
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/fa80ef59f2e8477eb99b528896b0ec33
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 1, p e1007464 (2020)
For women with access to healthcare and early detection, breast cancer deaths are caused primarily by metastasis rather than growth of the primary tumor. Metastasis has been difficult to study because it happens deep in the body, occurs over years, a
Externí odkaz:
https://doaj.org/article/12dd0af4abf94080b7a0990fad6da970
Autor:
Andrew J. Ewald, Takanari Inoue, Neil M. Neumann, Gabriela Frid, Alex Choi, Kester Coutinho, Orit Katarina Sirka, Veena Padmanaban, Dan Georgess
SF1: TGF-β1 promotes Twist1-induced epithelial dissemination without loss of adherens junction protein expression; SF2: Prkd1 inhibitors kb-NB142-70 and Gö-6976 block Twist1- induced dissemination dose-dependently; SF3: Dissemination defects in Twi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb168b87ba15431e460a7cccd5584cb
https://doi.org/10.1158/0008-5472.22424920
https://doi.org/10.1158/0008-5472.22424920
Autor:
Andrew J. Ewald, Takanari Inoue, Neil M. Neumann, Gabriela Frid, Alex Choi, Kester Coutinho, Orit Katarina Sirka, Veena Padmanaban, Dan Georgess
Dissemination is an essential early step in metastasis but its molecular basis remains incompletely understood. To define the essential targetable effectors of this process, we developed a 3D mammary epithelial culture model, in which dissemination i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9162d5cb647886fc255ae03fae1266e0
https://doi.org/10.1158/0008-5472.c.6511897
https://doi.org/10.1158/0008-5472.c.6511897
Autor:
Andrew J. Ewald, Takanari Inoue, Neil M. Neumann, Gabriela Frid, Alex Choi, Kester Coutinho, Orit Katarina Sirka, Veena Padmanaban, Dan Georgess
This file contains the full blot images of all Western blots.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543aad41430012ff7c35cef18cc9fbb7
https://doi.org/10.1158/0008-5472.22424926
https://doi.org/10.1158/0008-5472.22424926
Autor:
Andrew J. Ewald, Takanari Inoue, Neil M. Neumann, Gabriela Frid, Alex Choi, Kester Coutinho, Orit Katarina Sirka, Veena Padmanaban, Dan Georgess
Early inhibition of Prkd1 blocks epithelial invasion into ECM and loss of cell-cell adhesion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959df9b43d40d5ad1cbe4264881da680
https://doi.org/10.1158/0008-5472.22424914
https://doi.org/10.1158/0008-5472.22424914
Autor:
Andrew J. Ewald, Takanari Inoue, Neil M. Neumann, Gabriela Frid, Alex Choi, Kester Coutinho, Orit Katarina Sirka, Veena Padmanaban, Dan Georgess
Late inhibition of Prkd1 after onset of dissemination prevents disseminated cell migration and prevents de novo dissemination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194d23dc4b76656c2413e60d8eca5488
https://doi.org/10.1158/0008-5472.22424911
https://doi.org/10.1158/0008-5472.22424911
Autor:
Filemon S. Dela Cruz, Hiroyuki Yoda, Calvin J. Kuo, William C. Hahn, Kelly Kersten, Olivier Gevaert, Michitaka Nakano, Bruce K. Hua, Yohannes Tsehay, Han Liang, Yun Rose Li, Taofeek K. Owonikoko, Yunqi Yan, Katherine N. Liu, Stephen E. Kurtz, Andrew J. Ewald, Gordon B. Mills, Matthew Dunworth, Yuhao Wang, Eloise M. Grasset, Joseph Estabrook, Nicola Long, Vasanthi S. Viswanathan, Bridget Robinson, Shubhroz Gill, Matthew C. Perrone, Ken Chen, Suresh S. Ramalingam, Robert T. Manguso, Asmita Bhattacharya, Andrea Califano, Wei Zhou, Yuhong Du, Elodie Henriet, Jordana Brown, Francisca Vazquez, Michael T. McManus, Manisha Warrier, Gabriel Eades, Anuja Sathe, Yilong Zou, Yoko Kosaka, Matthew A. Reyna, Theodore P. Braun, Daniela S. Gerhard, Matthew F. Krummel, Allan Balmain, Tamilla Nechiporuk, Hanlee P. Ji, Quin Morrow, Emek Demir, Pablo Tamayo, Jessica Minnier, Michael C. Bassik, Kevin Watanabe-Smith, Xiulei Mo, Qi-Wen Fan, Nicole Nasholm, Sagar Lonial, Stuart L. Schreiber, Brent R. Stockwell, Nina K. Serwas, Sourav Bandyopadhyay, Brian J. Druker, Christina Curtis, Yuan-Hung Lo, Olga Nikolova, Qiankun Niu, Veena Padmanaban, Yuchen Ge, Cristina E. Tognon, Anupriya Agarwal, Christopher J. Kemp, Kremena Karagyozova, Haian Fu, Trevor Bivona, Dan Georgess, Nidhi Sahni, Stefan Oberlin, Issac S. Chan, Michael G. Lerner, Matt Hangauer, Jennifer Saultz, Wing Hing Wong, Ilya Shmulevich, Christin Schmidt, Yasir Suhail, Andy Kaempf, Alan Ashworth, Saumya R. Bollam, Tanaz Sharifnia, Jesse S. Boehm, Kasper Karlsson, Carlos S. Moreno, Neil Tay, Michael Grzadkowski, Kevin C. Brennan, Subhashini Jagu, Elizabeth M. Swisher, Ben Deneen, Jessica A. Talamas, Amber R. Smith, Joel S. Bader, Vlado Dančík, Andrew L. Kung, William A. Weiss, Hildur Knutsdottir, Tania Q. Vu, Lee Cooper, Kanako Yuki, Wei-Ching Chen, Bridget K. Wagner, Evan F. Lind, Josh Dempster, Marie Menard, Carla Grandori, Andrey A. Ivanov, William Kim, Jeffrey W. Tyner, Jonathan S. Weissman, Thomas Jacob, Paul A. Clemons, Jitong Cai, Kaitlyn Spees, Dan S. Kaufman
Publikováno v:
Cell, vol 184, iss 5
Cell
Cell
The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles r