Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Veena Coothankandaswamy"'
Autor:
J. Brian Morgan, Yang Liu, Veena Coothankandaswamy, Fakhri Mahdi, Mika B. Jekabsons, William H. Gerwick, Frederick A. Valeriote, Yu-Dong Zhou, Dale G. Nagle
Publikováno v:
Marine Drugs, Vol 13, Iss 3, Pp 1552-1568 (2015)
The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula). Kalkitoxin exhibited N-methyl-d-aspartate (NMDA)-mediated neurotoxicity and acted as an inhibitory ligand for
Externí odkaz:
https://doaj.org/article/81c9cdfe74804be6b9ba6bfe82baaec1
Autor:
Steven L Walker, Junko Ariga, Jonathan R Mathias, Veena Coothankandaswamy, Xiayang Xie, Martin Distel, Reinhard W Köster, Michael J Parsons, Kapil N Bhalla, Meera T Saxena, Jeff S Mumm
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29916 (2012)
Reporter-based assays underlie many high-throughput screening (HTS) platforms, but most are limited to in vitro applications. Here, we report a simple whole-organism HTS method for quantifying changes in reporter intensity in individual zebrafish ove
Externí odkaz:
https://doaj.org/article/cb453aee935a411d96f8838e1cb39404
Autor:
Kapil N. Bhalla, Ari M. Melnick, Jeffrey S. Mumm, Peng Huang, Baohua Sun, Christopher P. Mill, Stephanie S. Krieger, Dyana T. Saenz, Kyungsoo Ha, Hongwei Ma, Jianguang Chen, Veena Coothankandaswamy, Warren Fiskus
Figure legends for Supplemental Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8c975d899a166fa2c858a056d8dfb7
https://doi.org/10.1158/0008-5472.22413914.v1
https://doi.org/10.1158/0008-5472.22413914.v1
Autor:
Kapil N. Bhalla, Ari M. Melnick, Jeffrey S. Mumm, Peng Huang, Baohua Sun, Christopher P. Mill, Stephanie S. Krieger, Dyana T. Saenz, Kyungsoo Ha, Hongwei Ma, Jianguang Chen, Veena Coothankandaswamy, Warren Fiskus
SIRT2 is a protein deacetylase with tumor suppressor activity in breast and liver tumors where it is mutated; however, the critical substrates mediating its antitumor activity are not fully defined. Here we demonstrate that SIRT2 binds, deacetylates,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::468577d26c31f4eb3f93ef03c3273909
https://doi.org/10.1158/0008-5472.c.6508850.v1
https://doi.org/10.1158/0008-5472.c.6508850.v1
Autor:
Kapil N. Bhalla, Ari M. Melnick, Jeffrey S. Mumm, Peng Huang, Baohua Sun, Christopher P. Mill, Stephanie S. Krieger, Dyana T. Saenz, Kyungsoo Ha, Hongwei Ma, Jianguang Chen, Veena Coothankandaswamy, Warren Fiskus
Expanded, detailed methods and detailed reagent descriptions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e0fb32b49f37d87ca4e4cd415fdb79
https://doi.org/10.1158/0008-5472.22413908.v1
https://doi.org/10.1158/0008-5472.22413908.v1
Autor:
Kapil N. Bhalla, Ari M. Melnick, Jeffrey S. Mumm, Peng Huang, Baohua Sun, Christopher P. Mill, Stephanie S. Krieger, Dyana T. Saenz, Kyungsoo Ha, Hongwei Ma, Jianguang Chen, Veena Coothankandaswamy, Warren Fiskus
Supplemental Figure 1. Relative activity of overexpressed SIRT2 in breast cancer cells Supplemental Figure 2. Expression of other sirtuin proteins and HDAC6 in SIRT2 O/E and knockdown cells Supplemental Figure 3. SIRT2 overexpression increases Prdx1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011f495d64c00d1e5cf00828a779183a
https://doi.org/10.1158/0008-5472.22413911
https://doi.org/10.1158/0008-5472.22413911
Autor:
Vadivel Ganapathy, Sha Cao, Shengping Yang, Yangzom D. Bhutia, C. P. Reynolds, Ying Xu, Puttur D. Prasad, Jiro Ogura, Veena Coothankandaswamy, Pankaj K. Singh
Publikováno v:
British Journal of Pharmacology. 173:3292-3306
Background and Purpose Pancreatic cancer is a solid tumour that is often fatal. Hence, there is an urgent need to identify new drug targets for this disease. Highly proliferating cancer cells have an increased demand for nutrients and, therefore, nee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::538dd6e7848fec1277bba71dcfc94db1
https://doi.org/10.1111/bph.13616
https://doi.org/10.1111/bph.13616
Autor:
Warren Fiskus, Baohua Sun, Peng Huang, Jeff S. Mumm, Dyana T. Saenz, Christopher P. Mill, Veena Coothankandaswamy, Kapil N. Bhalla, Kyungsoo Ha, Stephanie Krieger, Jianguang Chen, Ari Melnick, Hongwei Ma
Publikováno v:
Cancer Research. 76:5467-5478
SIRT2 is a protein deacetylase with tumor suppressor activity in breast and liver tumors where it is mutated; however, the critical substrates mediating its antitumor activity are not fully defined. Here we demonstrate that SIRT2 binds, deacetylates,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299eb68c9bd64d192d4a3d57cdc5cdb3
https://doi.org/10.1158/0008-5472.can-16-0126
https://doi.org/10.1158/0008-5472.can-16-0126
Autor:
Kyungsoo Ha, Srilatha Nalluri, Rekha Rao, Warren Fiskus, Andrew Savoie, Kapil N. Bhalla, Veena Coothankandaswamy, Atul Joshi, Kathleen M. Buckley, Peter Atadja, Jianguo Tao, Ramesh Balusu, Eduardo M. Sotomayor
Publikováno v:
Clinical Cancer Research. 26:1531-1531
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bb5b437b9767bc492970c19f151cdb3
https://doi.org/10.1158/1078-0432.ccr-20-0412
https://doi.org/10.1158/1078-0432.ccr-20-0412
Autor:
Puttur D. Prasad, Muthusamy Thangaraju, Nagendra Singh, Vadivel Ganapathy, Veena Coothankandaswamy, Selvakumar Elangovan
Publikováno v:
Biochemical Journal. 450:169-178
SLC5A8 (solute carrier gene family 5A, member 8) is a sodium-coupled transporter for monocarboxylates. Among its substrates are the HDAC (histone deacetylase) inhibitors butyrate, propionate and pyruvate. Expression of SLC5A8 is silenced in cancers v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1282a98094df25ef720c16f72f0eefed
https://doi.org/10.1042/bj20121248
https://doi.org/10.1042/bj20121248