Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Veela B. Mehta"'
Autor:
David J. Huss, Michael K. Racke, Amy E. Lovett-Racke, Veela B. Mehta, Tracey L. Papenfuss, Haiyan Peng, Yuhong Yang, Mireia Guerau-de-Arellano
Publikováno v:
Journal of Biological Chemistry. 287:28017-28026
Dimethyl fumarate (DMF) is an effective novel treatment for multiple sclerosis in clinical trials. A reduction of IFN-γ-producing CD4(+) T cells is observed in DMF-treated patients and may contribute to its clinical efficacy. However, the cellular a
Autor:
Osama N. El-Assal, Hong Yi Zhang, Veela B. Mehta, Iyore A. Otabor, Yan Chen, Dana Wu, Andrei Radulescu, Chun Liang Chen, Gail E. Besner, Jiexiong Feng
Publikováno v:
Growth Factors. 28:82-97
Heparin-binding EGF-like growth factor (HB-EGF) protects the intestine from damage in animals. Future clinical trials of HB-EGF may involve administration of repeated doses of HB-EGF. Since HB-EGF activates EGF receptors which have been implicated in
Publikováno v:
Growth Factors. 26:301-315
Heparin-binding EGF-like growth factor (HB-EGF) is a member of the epidermal growth factor (EGF) family of ligands that is expressed by many cell types including endothelial cells. We have previously shown that HB-EGF stimulates angiogenesis in vitro
Autor:
Gail E. Besner, Veela B. Mehta
Publikováno v:
The Journal of Immunology. 175:1911-1918
NO produced by inducible NO synthase (iNOS) has been implicated in various pathophysiological processes including inflammation. Therefore, inhibitors of NO synthesis or iNOS gene expression have been considered as potential anti-inflammatory agents.
Autor:
Veela B. Mehta, Gail E. Besner
Publikováno v:
The Journal of Immunology. 171:6014-6022
Many cells upon injury mount extensive, compensatory responses that increase cell survival; however, the intracellular signals that regulate these responses are not completely understood. Heparin-binding epidermal growth factor-like growth factor (HB
Publikováno v:
Antioxidants & Redox Signaling. 4:639-646
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) has been shown to protect intestinal epithelial cells from anoxia/reoxygenation in vitro, and to protect the intestines from ischemia/reperfusion (I/R) injury in vivo. The goal of th
Publikováno v:
Journal of Pediatric Surgery. 36:1130-1135
Background/Purpose: The production of heparin-binding EGF-like growth factor (HB-EGF) is upregulated during organ injury and has a cytoprotective effect during hypoxic stress in intestinal epithelial cells in vitro and intestinal ischemia-reperfusion
Autor:
Todd A. Fehniger, Michael A. Caligiuri, Mark D. Wewers, Anand Ponnappan, Megan A. Cooper, Veela B. Mehta
Publikováno v:
European Journal of Immunology. 31:792-801
Natural killer (NK) cells are an early source of immunoregulatory cytokines during the innate immune response to viruses, bacteria, and parasites. NK cells provide requisite IFN-gamma to monocytes for the elimination of obligate intracellular pathoge
Publikováno v:
Journal of Biological Chemistry. 276:3820-3826
Interleukin (IL)-1beta and IL-18 are structurally similar proteins that require caspase-1 processing for activation. Both proteins are released from the cytosol by unknown pathway(s). To better characterize the release pathway(s) for IL-1beta and IL-
Autor:
Sarah K. Ceselski, Veela B. Mehta, Seth J. Corey, Melissa G. Hunter, Jennifer M. Parker, Brian Druker, Belinda R. Avalos
Publikováno v:
Blood. 85:3117-3126
The human granulocyte colony-stimulating factor receptor (hG-CSFR) belongs to the cytokine receptor superfamily. As with other members of this family, the cytoplasmic domain of hG-CSFR lacks intrinsic tyrosine kinase activity. To identify critical re