Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians.

Autor: Wang M; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Menon R; MedGenome Labs Ltd., Bengaluru, India., Mishra S; MedGenome Labs Ltd., Bengaluru, India., Patel AP; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts., Chaffin M; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Tanneeru D; MedGenome Labs Ltd., Bengaluru, India., Deshmukh M; MedGenome Labs Ltd., Bengaluru, India., Mathew O; MedGenome Labs Ltd., Bengaluru, India., Apte S; MedGenome Labs Ltd., Bengaluru, India., Devanboo CS; MedGenome Labs Ltd., Bengaluru, India., Sundaram S; MedGenome Labs Ltd., Bengaluru, India., Lakshmipathy P; MedGenome Labs Ltd., Bengaluru, India., Murugan S; MedGenome Labs Ltd., Bengaluru, India., Sharma KK; Eternal Heart Care Centre, Jaipur, India., Rajendran K; Narayana Health, Bengaluru, India., Santhosh S; MedGenome Labs Ltd., Bengaluru, India., Thachathodiyl R; Amrita Institute Medical Sciences, Kochi, India., Ahamed H; Amrita Institute Medical Sciences, Kochi, India., Balegadde AV; Amrita Institute Medical Sciences, Kochi, India., Alexander T; Kovai Medical Center and Hospital Research Foundation, Coimbatore, India., Swaminathan K; Kovai Medical Center and Hospital Research Foundation, Coimbatore, India., Gupta R; Eternal Heart Care Centre, Jaipur, India., Mullasari AS; Madras Medical Mission, Chennai, India., Sigamani A; Narayana Health, Bengaluru, India., Kanchi M; Narayana Health, Bengaluru, India., Peterson AS; MedGenome Inc., Foster City, California., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom., Danesh J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom., Di Angelantonio E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom., Naheed A; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh., Inouye M; Cambridge Baker Systems Genomics Initiative, Melbourne, Victoria, Australia, and Cambridge, United Kingdom; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Department of Clinical Pathology and School of BioSciences, University of Melbourne, Parkville, Victoria, Australia; The Alan Turing Institute, London, United Kingdom., Chowdhury R; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Centre for Non-Communicable Disease Research, Dhaka, Bangladesh., Vedam RL; MedGenome Labs Ltd., Bengaluru, India., Kathiresan S; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts; Verve Therapeutics, Cambridge, Massachusetts., Gupta R; MedGenome Labs Ltd., Bengaluru, India., Khera AV; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: avkhera@mgh.harvard.edu.

Publikováno v: Journal of the American College of Cardiology [J Am Coll Cardiol] 2020 Aug 11; Vol. 76 (6), pp. 703-714.