Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ved, Mehta"'
Autor:
Chao Qi, Pia Lavriha, Ved Mehta, Basavraj Khanppnavar, Inayathulla Mohammed, Yong Li, Michalis Lazaratos, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Ana-Nicoleta Bondar, Carmen W. Dessauer, Volodymyr M. Korkhov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzym
Externí odkaz:
https://doaj.org/article/8cc716af995d44c680e7cd3d009fb03e
Autor:
Ved Mehta, Basavraj Khanppnavar, Dina Schuster, Ilayda Kantarci, Irene Vercellino, Angela Kosturanova, Tarun Iype, Sasa Stefanic, Paola Picotti, Volodymyr M Korkhov
Publikováno v:
eLife, Vol 11 (2022)
Mycobacterium tuberculosis adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor of the mammalian membrane ACs and a model system for studies of their structure and function. Although the vital role of ACs in cellular signalling is well estab
Externí odkaz:
https://doaj.org/article/6a21e41f8fdc4cd79054b568a5329337
Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion
Autor:
Gaëlle Lentini, Rouaa Ben Chaabene, Oscar Vadas, Chandra Ramakrishnan, Budhaditya Mukherjee, Ved Mehta, Matteo Lunghi, Jonas Grossmann, Bohumil Maco, Rémy Visentin, Adrian B. Hehl, Volodymyr M. Korkhov, Dominique Soldati-Favre
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Host cell invasion by Toxoplasma gondii depends on the heavily phosphorylated RON complex, but the relevance and regulation of these modifications are not understood. Here, the authors identify the kinase RON13 as a key virulence factor, determine it
Externí odkaz:
https://doaj.org/article/b99ddeb7c5ca4acfb20ea9d41fb9e96c
Autor:
Rahul Chandwani, Karen Harpster, Julia E. Kline, Ved Mehta, Hui Wang, Stephanie L. Merhar, Terry L. Schwartz, Nehal A. Parikh
Publikováno v:
NeuroImage: Clinical, Vol 34, Iss , Pp 102987- (2022)
Infants born very preterm (VPT) are at risk of later visual problems. Although neonatal screening can identify ophthalmologic abnormalities, subtle perinatal brain injury and/or delayed brain maturation may be significant contributors to complex visu
Externí odkaz:
https://doaj.org/article/b55c22db03a8432d821ccf990174bc6c
Autor:
Basavraj Khanppnavar, Dina Schuster, Merve Özel, Ved Mehta, Alexander Leitner, Paola Picotti, Volodymyr M. Korkhov
Membrane adenylyl cyclase AC8 is regulated by G proteins and calmodulin (CaM), mediating the crosstalk between cAMP pathway and Ca2+signalling. Despite the importance of AC8 in physiology, including cognitive functions and memory, the structural basi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::792745eaa65e3b1b646c075e4039347c
https://doi.org/10.1101/2023.03.03.531047
https://doi.org/10.1101/2023.03.03.531047
Autor:
Basavraj Khanppnavar, Ved Mehta, Dina Schuster, Ilayda Kantarci, Irene Vercellino, Angela Kosturanova, Tarun Iype, Sasa Stefanic, Paola Picotti, Volodymyr M Korkhov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e08ddf41d7a83a595369ebbaab7bf5c5
https://doi.org/10.7554/elife.77032.sa2
https://doi.org/10.7554/elife.77032.sa2
Autor:
Ved, Mehta, Basavraj, Khanppnavar, Dina, Schuster, Ilayda, Kantarci, Irene, Vercellino, Angela, Kosturanova, Tarun, Iype, Sasa, Stefanic, Paola, Picotti, Volodymyr M, Korkhov
Publikováno v:
eLife. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::46c29917fb271eb41c848640a9f14b37
https://pubmed.ncbi.nlm.nih.gov/35980026
https://pubmed.ncbi.nlm.nih.gov/35980026
Autor:
C. Qi, B. Khanppnavar, Andreas Plueckthun, P. Lavriha, Yan Li, Volodymyr M. Korkhov, B. Dreier, Ved Mehta, Ana-Nicoleta Bondar, Jonas V. Schaefer, Michalis Lazaratos, Inayatulla Mohammed, Carmen W. Dessauer
Publikováno v:
Nature Communications, 13 (1)
Adenylyl cyclase 9 (AC9) is a membrane-bound enzyme that converts ATP into cAMP. The enzyme is weakly activated by forskolin, fully activated by the G protein Gαs subunit and is autoinhibited by the AC9 C-terminus. Although our recent structural stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f408d8d097215e104e5e72d262b5dd
Autor:
Ved Mehta, Basavraj Khanppnavar, Dina Schuster, Ilayda Kantarci, Irene Vercellino, Angela Kosturanova, Tarun Iype, Sasa Stefanic, Paola Picotti, Volodymyr M. Korkhov
Mycobacterium tuberculosisadenylyl cyclase (AC) Rv1625c / Cya is an evolutionary ancestor of the mammalian membrane ACs and a model system for studies of their structure and function. Although the vital role of ACs in cellular signaling is well estab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2f0b5c3494fe0f8773c5af8fdd1f453
https://doi.org/10.1101/2021.12.01.470738
https://doi.org/10.1101/2021.12.01.470738
Autor:
Rahul Chandwani, Karen Harpster, Julia E. Kline, Ved Mehta, Hui Wang, Stephanie L. Merhar, Terry L. Schwartz, Nehal A. Parikh
Publikováno v:
NeuroImage. Clinical. 34
Infants born very preterm (VPT) are at risk of later visual problems. Although neonatal screening can identify ophthalmologic abnormalities, subtle perinatal brain injury and/or delayed brain maturation may be significant contributors to complex visu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2bffc29b8edc257ab635c0ba55e15d
https://pubmed.ncbi.nlm.nih.gov/35290855
https://pubmed.ncbi.nlm.nih.gov/35290855