MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

Autor: Castanier Céline, Zemirli Naima, Portier Alain, Garcin Dominique, Bidère Nicolas, Vazquez Aimé, Arnoult Damien

Publikováno v: BMC Biology, Vol 10, Iss 1, p 44 (2012)

Abstract Background During a viral infection, the intracellular RIG-I-like receptors (RLRs) sense viral RNA and signal through the mitochondrial antiviral signaling adaptor MAVS (also known as IPS-1, Cardif and VISA) whose activation triggers a rapid

Externí odkaz: https://doaj.org/article/eb9d8c4ab8fc4fceb03124e6e7587012

Subgroups of pelvic pain are differentially associated with endometriosis and inflammatory comorbidities: a latent class analysis.

Autor: Ghiasi M; Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, United States., Chang C; Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, United States.; Office of Medical Education Research and Development, Michigan State University, East Lansing, MI, United States., Shafrir AL; Division of Adolescent and Young Adult Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.; Boston Center for Endometriosis, Boston Children's Hospital and Brigham and Women's Hospital, Boston, MA, United States., Vitonis AF; Boston Center for Endometriosis, Boston Children's Hospital and Brigham and Women's Hospital, Boston, MA, United States.; Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States., Sasamoto N; Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States., Vazquez AI; Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, United States.; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, United States., DiVasta AD; Division of Adolescent and Young Adult Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.; Boston Center for Endometriosis, Boston Children's Hospital and Brigham and Women's Hospital, Boston, MA, United States., Upson K; Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, United States., Sieberg CB; Biobehavioral Pain Innovations Lab, Department of Psychiatry & Behavioral Sciences, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.; Pain & Affective Neuroscience Center, Department of Anesthesiology, Critical Care, & Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States., Terry KL; Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States., Holzman CB; Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, United States., Missmer SA; Division of Adolescent and Young Adult Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.; Boston Center for Endometriosis, Boston Children's Hospital and Brigham and Women's Hospital, Boston, MA, United States.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States.; Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States.

Publikováno v: Pain [Pain] 2024 Sep 01; Vol. 165 (9), pp. 2119-2129. Date of Electronic Publication: 2024 Apr 02.

Association of Gout Polygenic Risk Score With Age at Disease Onset and Tophaceous Disease in European and Polynesian Men With Gout.

Autor: Sumpter NA; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, and Department of Biochemistry, University of Otago, Dunedin, New Zealand., Takei R; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham., Cadzow M; Department of Biochemistry, University of Otago, Dunedin, New Zealand., Topless RKG; Department of Biochemistry, University of Otago, Dunedin, New Zealand., Phipps-Green AJ; Department of Biochemistry, University of Otago, Dunedin, New Zealand., Murphy R; Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand., de Zoysa J; Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand., Watson H; Ngāti Porou Hauora Trust, Te Puia Springs, New Zealand., Qasim M; Ngāti Porou Hauora Trust, Te Puia Springs, New Zealand., Lupi AS; Department of Epidemiology and Biostatistics, Michigan State University, and The Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, Michigan., Abhishek A; Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham City Hospital, Nottingham, UK, and GlobalGoutGenetics Consortium., Andrés M; GlobalGoutGenetics Consortium, and Department of Rheumatology, Alicante General University Hospital-ISABIAL, Miguel Hernandez University, Alicante, Spain., Crișan TO; GlobalGoutGenetics Consortium, and Department of Medical Genetics, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Doherty M; Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham City Hospital, Nottingham, UK, and GlobalGoutGenetics Consortium., Jacobsson L; GlobalGoutGenetics Consortium, and Department of Rheumatology & Inflammation Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Sweden., Janssen M; GlobalGoutGenetics Consortium, and Complex Gout Expert Centre, Department of Rheumatology, Viecuri Medical Centre, Venlo, The Netherlands., Jansen TL; GlobalGoutGenetics Consortium, and Complex Gout Expert Centre, Department of Rheumatology, Viecuri Medical Centre, Venlo, The Netherlands., Joosten LAB; GlobalGoutGenetics Consortium, and Department of Medical Genetics, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, and Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands., Kapetanovic M; GlobalGoutGenetics Consortium, and Lund University and Skåne University Hospital, Lund, Sweden., Lioté F; Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand., Matsuo H; GlobalGoutGenetics Consortium, and Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan., McCarthy GM; GlobalGoutGenetics Consortium, and Mater Misericordiae University Hospital and University College, Dublin, Ireland., Perez-Ruiz F; GlobalGoutGenetics Consortium, and Rheumatology Division, Osakidetza, OSI EE-Cruces, Cruces University Hospital, Barakaldo, Biocruces-Bizkaia Health Research Institute, Barakaldo, and the Medicine Department of the Medicine School of the University of the Basque Country, Leioa, Spain., Riches P; GlobalGoutGenetics Consortium, and IGC, University of Edinburgh, Scotland., Richette P; GlobalGoutGenetics Consortium, and Hôpital Lariboisière, Assistance Publique-Hopitaux de Paris, and INSERM UMR-1132 and Université Paris Cité, Paris, France., Roddy E; GlobalGoutGenetics Consortium, and School of Medicine, Keele University, Keele, Staffordshire, UK., Stiburkova B; GlobalGoutGenetics Consortium, and Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic, and Institute of Rheumatology, Prague, Czech Republic., So A; GlobalGoutGenetics Consortium, and Service of Rheumatology, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland., Tausche AK; GlobalGoutGenetics Consortium, and Division of Rheumatology, University Clinic Carl Gustav Carus at the TU Dresden, Dresden, Germany., Torres RJ; GlobalGoutGenetics Consortium, and Department of Biochemistry, La Paz University Hospital Health Research Institute (FIBHULP), IdiPaz, and Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain., Uhlig T; GlobalGoutGenetics Consortium, and Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway., Major TJ; Department of Biochemistry, University of Otago, Dunedin, New Zealand., Stamp LK; GlobalGoutGenetics Consortium, and Department of Medicine, University of Otago, Christchurch, New Zealand., Dalbeth N; Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand, and GlobalGoutGenetics Consortium., Choi HK; Clinical Epidemiology Unit, Massachusetts General Hospital, Boston., Vazquez AI; Department of Epidemiology and Biostatistics, Michigan State University, and The Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, Michigan., Leask MP; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham., Reynolds RJ; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham., Merriman TR; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and GlobalGoutGenetics Consortium.

Publikováno v: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2023 May; Vol. 75 (5), pp. 816-825. Date of Electronic Publication: 2023 Mar 25.

Local genetic covariance between serum urate and kidney function estimated with Bayesian multitrait models.

Autor: Lupi AS; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI 48824, USA.; Institute for Quantitative Health Science and Engineering, Systems Biology, Michigan State University, East Lansing, MI 48824, USA., Sumpter NA; Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA., Leask MP; Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Department of Biochemistry, University of Otago, Dunedin 9016, New Zealand., O'Sullivan J; Liggins Institute, The University of Auckland, Auckland 1142, New Zealand., Fadason T; Liggins Institute, The University of Auckland, Auckland 1142, New Zealand., de Los Campos G; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI 48824, USA.; Institute for Quantitative Health Science and Engineering, Systems Biology, Michigan State University, East Lansing, MI 48824, USA.; Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA., Merriman TR; Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA., Reynolds RJ; Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA., Vazquez AI; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI 48824, USA.; Institute for Quantitative Health Science and Engineering, Systems Biology, Michigan State University, East Lansing, MI 48824, USA.

Publikováno v: G3 (Bethesda, Md.) [G3 (Bethesda)] 2022 Aug 25; Vol. 12 (9).

Mapping pleiotropic loci using a fast-sequential testing algorithm.

Autor: Aguate FM; Department of Epidemiology & Biostatistics, IQ - Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA. matiasfe@msu.edu., Vazquez AI; Department of Epidemiology & Biostatistics, IQ - Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA., Merriman TR; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., de Los Campos G; Department of Epidemiology & Biostatistics, IQ - Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA. gustavoc@msu.edu.; Department of Statistics & Probability, Michigan State University, East Lansing, MI, USA. gustavoc@msu.edu.

Publikováno v: European journal of human genetics : EJHG [Eur J Hum Genet] 2021 Dec; Vol. 29 (12), pp. 1762-1773. Date of Electronic Publication: 2021 Jun 18.