Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Vaughn V. Smider"'
Autor:
Purushotham Selvakumar, Ana I. Fernández-Mariño, Nandish Khanra, Changhao He, Alice J. Paquette, Bing Wang, Ruiqi Huang, Vaughn V. Smider, William J. Rice, Kenton J. Swartz, Joel R. Meyerson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune responses. Here, the authors report structures of the Kv1.3 potassium channel with and without immunoglobulin modulators, shedding light on the
Externí odkaz:
https://doaj.org/article/d07ce3fe1deb42c097bcb4bfddf1e075
Autor:
Jeannine A. Ott, Jeremy K. Haakenson, Abigail R. Kelly, Claire Christian, Michael F. Criscitiello, Vaughn V. Smider
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In the mammalian immune system, the surrogate light chain (SLC) shapes the antibody repertoire during B cell development by serving as a checkpoint for production of functional heavy chains (HC). Structural studies indicate that tail regions of VpreB
Externí odkaz:
https://doaj.org/article/be2d465e729c447ebc5209b913d1b86a
Autor:
Brevin A. Smider, Vaughn V. Smider
Publikováno v:
BMC Immunology, Vol 21, Iss 1, Pp 1-7 (2020)
Abstract Background Cow antibodies are very unusual in having exceptionally long CDR H3 regions. The genetic basis for this length largely derives from long heavy chain diversity (DH) regions, with a single “ultralong” DH, IGHD8–2, encoding ove
Externí odkaz:
https://doaj.org/article/d139c40dc76b4a1896787925f6bac729
Autor:
Lukas Pekar, Daniel Klewinghaus, Paul Arras, Stefania C. Carrara, Julia Harwardt, Simon Krah, Desislava Yanakieva, Lars Toleikis, Vaughn V. Smider, Harald Kolmar, Stefan Zielonka
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In this work, we have generated epidermal growth factor receptor (EGFR)-specific cattle-derived ultralong CDR-H3 antibodies by combining cattle immunization with yeast surface display. After immunization, ultralong CDR-H3 regions were specifically am
Externí odkaz:
https://doaj.org/article/24ca0e9a474849189f54ea21218b575c
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Typical antibodies found in humans and mice usually have short CDR H3s and generally flat binding surfaces. However, cows possess a subset of antibodies with ultralong CDR H3s that can range up to 70 amino acids and form a unique “stalk and knob”
Externí odkaz:
https://doaj.org/article/21963ece231745aca15cc2ea3f16ece3
Autor:
Jeannine A. Ott, Christian Mitchell, Morgan Sheppard, Thad C. Deiss, J. M. Cody Horton, Jeremy K. Haakenson, Ruiqi Huang, Abigail R. Kelley, Brian W. Davis, James N. Derr, Vaughn V. Smider, Michael F. Criscitiello
Publikováno v:
Immunogenetics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::087bba0250895a5fbf1af3d1f0b2c893
https://doi.org/10.1007/s00251-023-01305-9
https://doi.org/10.1007/s00251-023-01305-9
Autor:
Ruiqi Huang, Jessie Low-Gan, Gabrielle Warner, Abigail Kelley, Duncan McGregor, Vaughn V. Smider
Publikováno v:
bioRxiv
COVID-19, the clinical syndrome caused by the SARS-CoV-2 virus, has rapidly spread globally causing tens of millions of infections and over a million deaths. The potential animal reservoirs for SARS-CoV-2 are currently unknown, however sequence analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ea657598e532c889f525edfea84131
https://doi.org/10.1042/bcj20200908
https://doi.org/10.1042/bcj20200908
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950).
Ab “ultralong” third H chain complementarity-determining regions (CDR H3) appear unique to bovine Abs and may enable binding to difficult epitopes that shorter CDR H3 regions cannot easily access. Diversity is concentrated in the “knob” domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a7395b444e1b5373dea7ab16ef1166
https://pubmed.ncbi.nlm.nih.gov/36270765
https://pubmed.ncbi.nlm.nih.gov/36270765
Autor:
Jeremy K. Haakenson, Gabrielle Warner, Thaddeus C. Deiss, Michael F. Criscitiello, Waithaka Mwangi, Vaughn V. Smider
Publikováno v:
ImmunoHorizons
Ab diversity in most vertebrates results from the assortment of amino acid side chains on CDR loops formed through V(D)J recombination. Cows (Bos taurus) have a low combinatorial diversity potential because of a small number of highly homologous V, D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fc7f80a6958c790434d02422ec2652
https://doi.org/10.4049/immunohorizons.1900058
https://doi.org/10.4049/immunohorizons.1900058
Autor:
Vaughn V. Smider, Brevin A. Smider
Publikováno v:
BMC Immunology
BMC Immunology, Vol 21, Iss 1, Pp 1-7 (2020)
BMC Immunology, Vol 21, Iss 1, Pp 1-7 (2020)
Background Cow antibodies are very unusual in having exceptionally long CDR H3 regions. The genetic basis for this length largely derives from long heavy chain diversity (DH) regions, with a single “ultralong” DH, IGHD8–2, encoding over 50 amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dec87b2a5b2e61ad378d037ce5b0ce9
https://doi.org/10.1186/s12865-020-00359-8
https://doi.org/10.1186/s12865-020-00359-8