Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Vaughn Thada"'
Autor:
Qinqin Jiang, Martina Foglizzo, Yaroslav I. Morozov, Xuejiao Yang, Arindam Datta, Lei Tian, Vaughn Thada, Weihua Li, Elton Zeqiraj, Roger A. Greenberg
Publikováno v:
Journal of Cell Biology. 221
The BRCA1-A complex contains matching lysine-63 ubiquitin (K63-Ub) binding and deubiquitylating activities. How these functionalities are coordinated to effectively respond to DNA damage remains unknown. We generated Brcc36 deubiquitylating enzyme (D
Autor:
Kavi P. M. Mehta, Vaughn Thada, Runxiang Zhao, Archana Krishnamoorthy, Micheal Leser, Kristie Lindsey Rose, David Cortez
Publikováno v:
Science Advances. 8
Replication-coupled DNA repair and damage tolerance mechanisms overcome replication stress challenges and complete DNA synthesis. These pathways include fork reversal, translesion synthesis, and repriming by specialized polymerases such as PRIMPOL. H
Autor:
Vaughn, Thada, Roger A, Greenberg
Publikováno v:
DNA Repair (Amst)
Accurate DNA repair is essential for cellular and organismal homeostasis, and DNA repair defects result in genetic diseases and cancer predisposition. Several environmental factors, such as ultraviolet light, damage DNA, but many other molecules with
Autor:
Vaughn Thada, David Cortez
Publikováno v:
J Biol Chem
DNA damage response Ser/Thr kinases, including ataxia telangiectasia-mutated (ATM) and Rad3-related (ATR), control cell cycle progression, DNA repair, and apoptosis. ATR is activated by ETAA1 activator of ATR kinase (ETAA1) or DNA topoisomerase II bi
Autor:
David Cortez, Vaughn Thada
Publikováno v:
The Journal of Biological Chemistry
The checkpoint kinase ATR regulates DNA repair, cell cycle progression, and other DNA damage and replication stress responses. ATR signaling is stimulated by an ATR activating protein, and in metazoan cells, there are at least two ATR activators: TOP
Publikováno v:
Journal of Cellular and Molecular Medicine
About 10% of inherited diseases are caused by nonsense mutations [Trends Mol Med 18 (2012) 688], and nonsense suppression drug therapy promoting translation through premature stop codons is an emerging therapeutic approach. Infantile neuronal ceroid