Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus

Autor: Dong, J, Levine, DM, Buas, MF, Zhang, R, Onstad, L, Fitzgerald, RC, Stomach and Oesophageal Cancer Study (SOCS) Consortium, Corley, DA, Shaheen, NJ, Lagergren, J, Hardie, LJ, Reid, BJ, Iyer, PG, Risch, HA, Caldas, C, Caldas, I, Pharoah, PD, Liu, G, Gammon, MD, Chow, W-H, Bernstein, L, Bird, NC, Ye, W, Wu, AH, Anderson, LA, MacGregor, S, Whiteman, DC, Vaughan, TL, Thrift, AP

Publikováno v: Dong, J, Levine, D, Buas, M, Zhang, R, Onstad, L, Fitzgerald, R C, consortium, S A O C S, Corley, D A, Shaheen, N J, Lagergren, J, Hardie, L J, Reid, B J, Iyer, P G, Risch, H A, Caldas, C, Caldas, I, Pharoah, P D, Liu, G, Gammon, M D, Chow, W-H, Bernstein, L, Bird, N C, Ye, W, Wu, A H, Anderson, L A, Macgregor, S, Whiteman, D C, Vaughan, T L & Thrift, A 2018, ' Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus ', Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association . https://doi.org/10.1016/j.cgh.2018.03.007

Background & Aims: Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci for esophageal adenocarcinoma (EA) and Barrett’s esophagus (BE). However, variants in these loci account for a small fraction of cases of EA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::447fd3561641347d5c536d75bbaee328
https://pure.qub.ac.uk/en/publications/2a42322e-0183-4f59-9170-608e0e4fa6bb

Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett's Esophagus

Autor: Palles, C, Chegwidden, L, Li, X, Findlay, JM, Farnham, G, Giner, FC, Peppelenbosch, MP, Kovac, M, Adams, CL, Prenen, H, Briggs, S, Harrison, R, Sanders, S, MacDonald, D, Haigh, C, Tucker, A, Love, S, Nanji, M, Decaestecker, J, Ferry, D, Rathbone, B, Hapeshi, J, Barr, H, Moayyedi, P, Watson, P, Zietek, B, Maroo, N, Gay, L, Underwood, T, Boulter, L, McMurtry, H, Monk, D, Patel, P, Ragunath, K, Al Dulaimi, D, Murray, I, Koss, K, Veitch, A, Trudgill, N, Nwokolo, C, Rembacken, B, Atherfold, P, Green, E, Ang, Y, Kuipers, EJ, Chow, W, Paterson, S, Kadri, S, Beales, I, Grimley, C, Mullins, P, Beckett, C, Farrant, M, Dixon, A, Kelly, S, Johnson, M, Wajed, S, Dhar, A, Sawyer, E, Roylance, R, Onstad, L, Gammon, MD, Corley, DA, Shaheen, NJ, Bird, NC, Hardie, LJ, Reid, BJ, Ye, W, Liu, G, Romero, Y, Bernstein, L, Wu, AH, Casson, AG, Fitzgerald, R, Whiteman, DC, Risch, HA, Levine, DM, Vaughan, TL, Verhaar, AP, van den Brande, J, Toxopeus, EL, Spaander, MC, Wijnhoven, BPL, van der Laan, LJW, Krishnadath, K, Wijmenga, C, Trynka, G, McManus, R, Reynolds, JV, O'Sullivan, J, MacMathuna, P, McGarrigle, SA, Kelleher, D, Vermeire, S, Cleynen, I, Bisschops, R, Tomlinson, I, Jankowski, J

Publikováno v: Gastroenterology, 148(2), 367-378. W.B. Saunders
Gastroenterology, 148(2), 367-378. W B SAUNDERS CO-ELSEVIER INC
Gastroenterology, 148(2), 367-378. W.B. Saunders Ltd

Background & Aims\ud \ud Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6808971181ef312a5e61497f90ed4569
https://pure.eur.nl/en/publications/2726e687-9c36-4a31-b334-50ee7af8539b

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