Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Vasuretha Chandar"'
Autor:
Yongzhen Liu, Thomas R. Cafiero, Debby Park, Abhishek Biswas, Benjamin Y. Winer, Cheul H. Cho, Yaron Bram, Vasuretha Chandar, Aoife K. O’ Connell, Hans P. Gertje, Nicholas Crossland, Robert E. Schwartz, Alexander Ploss
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Hepatitis B virus (HBV) only infects humans and chimpanzees, posing major challenges for modeling HBV infection and chronic viral hepatitis. The major barrier in establishing HBV infection in non-human primates lies at incompatibilities betw
Externí odkaz:
https://doaj.org/article/715209dd3f1c45be80f29128c56a1eea
Autor:
Yongzhen Liu, Debby Park, Thomas R. Cafiero, Yaron Bram, Vasuretha Chandar, Anna Tseng, Hans P. Gertje, Nicholas A. Crossland, Lishan Su, Robert E. Schwartz, Alexander Ploss
Publikováno v:
JHEP Reports, Vol 4, Iss 9, Pp 100535- (2022)
Background & Aims: HBV exhibits wide genetic diversity with at least 9 genotypes (GTs), which differ in terms of prevalence, geographic distribution, natural history, disease progression, and treatment outcome. However, differences in HBV replicative
Externí odkaz:
https://doaj.org/article/1554fc7886654cae9e56bd1c430ac1fc
Autor:
Lissenya B. Argueta, Lauretta A. Lacko, Yaron Bram, Takuya Tada, Lucia Carrau, André Figueiredo Rendeiro, Tuo Zhang, Skyler Uhl, Brienne C. Lubor, Vasuretha Chandar, Cristianel Gil, Wei Zhang, Brittany J. Dodson, Jeroen Bastiaans, Malavika Prabhu, Sean Houghton, David Redmond, Christine M. Salvatore, Yawei J. Yang, Olivier Elemento, Rebecca N. Baergen, Benjamin R. tenOever, Nathaniel R. Landau, Shuibing Chen, Robert E. Schwartz, Heidi Stuhlmann
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104223- (2022)
Summary: The effect of SARS-CoV-2 infection on placental function is not well understood. Analysis of placentas from women who tested positive at delivery showed SARS-CoV-2 genomic and subgenomic RNA in 22 out of 52 placentas. Placentas from two moth
Externí odkaz:
https://doaj.org/article/10e8c8bb49714f07ba4f189eb87775e5
Autor:
Jose M. Adrover, Lucia Carrau, Juliane Daßler-Plenker, Yaron Bram, Vasuretha Chandar, Sean Houghton, David Redmond, Joseph R. Merrill, Margaret Shevik, Benjamin R. tenOever, Scott K. Lyons, Robert E. Schwartz, Mikala Egeblad
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Severe acute lung injury has few treatment options and a high mortality rate. Upon injury, neutrophils infiltrate the lungs and form neutrophil extracellular traps (NETs), damaging the lungs and driving an exacerbated immune response. Unfortunately,
Externí odkaz:
https://doaj.org/article/12ddc5fdf3f044f9b0d26f8c3e6fe90c
Autor:
Edward R Kastenhuber, Marisa Mercadante, Benjamin Nilsson-Payant, Jared L Johnson, Javier A Jaimes, Frauke Muecksch, Yiska Weisblum, Yaron Bram, Vasuretha Chandar, Gary R Whittaker, Benjamin R tenOever, Robert E Schwartz, Lewis Cantley
Publikováno v:
eLife, Vol 11 (2022)
Coagulopathy is a significant aspect of morbidity in COVID-19 patients. The clotting cascade is propagated by a series of proteases, including factor Xa and thrombin. While certain host proteases, including TMPRSS2 and furin, are known to be importan
Externí odkaz:
https://doaj.org/article/1ff37db056a54d4d8ee1c896a12329b4
Autor:
Dipankar Bhattacharya, Brittany Basta, Jose M. Mato, Amanda Craig, David Fernández-Ramos, Fernando Lopitz-Otsoa, Darya Tsvirkun, Liat Hayardeny, Vasuretha Chandar, Robert E. Schwartz, Augusto Villanueva, Scott L. Friedman
Publikováno v:
JHEP Reports, Vol 3, Iss 3, Pp 100237- (2021)
Summary: Background & Aims: Aramchol is a fatty acid-bile acid conjugate that reduces liver fat content and is being evaluated in a phase III clinical trial for non-alcoholic steatohepatitis (NASH). Aramchol attenuates NASH in mouse models and decrea
Externí odkaz:
https://doaj.org/article/07ba8fe24ed7447a841dc9fde349a0da
Autor:
Yaron Bram, Xiaohua Duan, Benjamin E. Nilsson-Payant, Vasuretha Chandar, Hao Wu, Derek Shore, Alvaro Fajardo, Saloni Sinha, Nora Hassan, Harel Weinstein, Benjamin R. TenOever, Shuibing Chen, Robert E. Schwartz
Publikováno v:
ACS Bio & Med Chem Au. 2:627-641
The SARS-CoV-2 pandemic is an ongoing threat to global health, and the continuing emergence of contagious variants highlights the urgent need for additional antiviral therapy to attenuate COVID-19 disease. The SARS-CoV-2 main protease (3CL
Autor:
Daniel Batlle, Vanessa Monteil, Elena Garreta, Luise Hassler, Jan Wysocki, Vasuretha Chandar, Robert E. Schwartz, Ali Mirazimi, Nuria Montserrat, Michael Bader, Josef M. Penninger
Publikováno v:
Cell. 185:1837-1839
Autor:
Paôline Laurent, Chao Yang, André F. Rendeiro, Benjamin E. Nilsson-Payant, Lucia Carrau, Vasuretha Chandar, Yaron Bram, Benjamin R. tenOever, Olivier Elemento, Lionel B. Ivashkiv, Robert E. Schwartz, Franck J. Barrat
Publikováno v:
Science Immunology. 7
Lung-infiltrating macrophages create a marked inflammatory milieu in a subset of patients with COVID-19 by producing a cytokine storm, which correlates with increased lethality. However, these macrophages are largely not infected by SARS-CoV-2, so th
Autor:
Chanel Richardson, Duc-Huy T. Nguyen, Jiwoon Park, Yaron Bram, Robert E. Schwartz, Vasuretha Chandar, Vikas Gupta
Publikováno v:
Annual Review of Biomedical Engineering. 23:517-546
Liver disease is an important clinical problem, impacting 600 million people worldwide. It is the 11th-leading cause of death in the world. Despite constant improvement in treatment and diagnostics, the aging population and accumulated risk factors l