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pro vyhledávání: '"Vasundhara D. Kalasapudi"'
Publikováno v:
Brain research. 553(1)
Lithium salts are considered the most effective agents used in treating manic-depression. Previous studies in PC12 pheochromocytoma cells indicate that lithium has a dramatic augmenting effect on expression of thefos proto-oncogene, a component of th
Autor:
A. Boyle, Herbert M. Lachman, Giulia Sheftel, M. M. Divish, Vasundhara D. Kalasapudi, Demitri F. Papolos
Publikováno v:
Journal of neuroscience research. 28(1)
Lithium salts are the most effective agents used in treating manic-depressive illness. It has been suggested that lithium's therapeutic efficacy could be due to an inhibitory effect on either inositol phospholipid (IP) and/or cyclic nucleotide metabo
Autor:
Vasundhara D. Kalasapudi, Giulia Sheftel, Margaret M. Divish, Demitri F. Papolos, Herbert M. Lachman
Publikováno v:
Brain research. 521(1-2)
It has been proposed that lithium's antimanic action is due to an effect on phosphoinositide metabolism. Second messengers generated by this pathway regulate calcium mobilization and the activity of the serine and threonine kinase, protein kinase C (