Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

Autor: Jones, Gregory T, Tromp, Gerard, Kuivaniemi, Helena, Gretarsdottir, Solveig, Baas, Annette F, Giusti, Betti, Strauss, Ewa, Van't Hof, Femke N G, Webb, Thomas R, Erdman, Robert, Ritchie, Marylyn D, Elmore, James R, Verma, Anurag, Pendergrass, Sarah, Kullo, Iftikhar J, Ye, Zi, Peissig, Peggy L, Gottesman, Omri, Verma, Shefali S, Malinowski, Jennifer, Rasmussen-Torvik, Laura J, Borthwick, Kenneth M, Smelser, Diane T, Crosslin, David R, de Andrade, Mariza, Ryer, Evan J, McCarty, Catherine A, Böttinger, Erwin P, Pacheco, Jennifer A, Crawford, Dana C, Carrell, David S, Gerhard, Glenn S, Franklin, David P, Carey, David J, Phillips, Victoria L, Williams, Michael J A, Wei, Wenhua, Blair, Ross, Hill, Andrew A, Vasudevan, Thodor M, Lewis, David R, Thomson, Ian A, Krysa, Jo, Hill, Geraldine B, Roake, Justin, Merriman, Tony R, Oszkinis, Grzegorz, Galora, Silvia, Saracini, Claudia, Abbate, Rosanna, Pulli, Raffaele, Pratesi, Carlo, Saratzis, Athanasios, Verissimo, Ana R, Bumpstead, Suzannah, Badger, Stephen A, Clough, Rachel E, Cockerill, Gillian, Hafez, Hany, Scott, D Julian A, Futers, T Simon, Romaine, Simon P R, Bridge, Katherine, Griffin, Kathryn J, Bailey, Marc A, Smith, Alberto, Thompson, Matthew M, van Bockxmeer, Frank M, Matthiasson, Stefan E, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D, Teijink, Joep A W, Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A, Lindholt, Jes S, Hughes, Anne, Bradley, Declan T, Stirrups, Kathleen, Golledge, Jonathan, Norman, Paul E, Powell, Janet T, Humphries, Steve E, Hamby, Stephen E, Goodall, Alison H, Nelson, Christopher P, Sakalihasan, Natzi, Courtois, Audrey, Ferrell, Robert E, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Eicher, John D, Johnson, Andrew D, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Schadt, Eric E, Björkegren, Johan L M, Lipovich, Leonard, Drolet, Anne M, Verhoeven, Eric L, Zeebregts, Clark J, Geelkerken, Robert H, van Sambeek, Marc R, van Sterkenburg, Steven M, de Vries, J.P.P.M., Stefansson, Kari, Thompson, John R, de Bakker, Paul I W, Deloukas, Panos, Sayers, Robert D, Harrison, Seamus C, van Rij, Andre M, Samani, Nilesh J, Bown, Matthew J

Publikováno v: Jones, G T, Tromp, G, Kuivaniemi, H, Gretarsdottir, S, Baas, A F, Giusti, B, Strauss, E, van 't Hof, F N, Webb, T, Erdman, R, Ritchie, M D, Elmore, J R, Verma, A, Pendergrass, S, Kullo, I J, Ye, Z, Peissig, P L, Gottesman, O, Verma, S S, Malinowski, J, Rasmussen-Torvik, L J, Borthwick, K, Smelser, D T, Crosslin, D R, de Andrade, M, Ryer, E J, McCarty, C A, Bottinger, E P, Pacheco, J A, Crawford, D C, Carrell, D S, Gerhard, G S, Franklin, D P, Carey, D J, Phillips, V L, Williams, M J, Wei, W, Blair, R, Hill, A A, Vasudevan, T M, Lewis, D R, Thomson, I A, Krysa, J, Hill, G B, Roake, J, Merriman, T R, Oszkinis, G, Galora, S, Saracini, C, Abbate, R, Pulli, R, Pratesi, C, Saratzis, A, Verissimo, A, Bumpstead, S J, Badger, S A, Clough, R E, Cockerill, G W, Hafez, H, Scott, D J, Futers, T S, Romaine, S P, Bridge, K, Griffin, K J, Bailey, M A, Smith, A, Thompson, M M, van Bockxmeer, F, Matthiasson, S E, Thorleifsson, G, Thorsteinsdottir, U, Blankensteijn, J D, Teijink, J A, Wijmenga, C, de Graaf, J, Kiemeney, L A, Lindholt, J S, Hughes, A E, Bradley, D T, Stirrups, K, Golledge, J, Norman, P E, Powell, J T, Humphries, S E, Hamby, S E, Goodall, A H, Nelson, C P, Sakalihasan, N, Courtois, A, Ferrell, R E, Eriksson, P, Folkersen, L, Franco-Cereceda, A, Eicher, J D, Johnson, A D, Betsholtz, C, Ruusalepp, A, Franzén, O, Schadt, E, Björkegren, J L, Lipovich, L, Drolet, A M, Verhoeven, E, Zeebregts, C J, Geelkerken, R H, van Sambeek, M R, van Sterkenburg, S M, de Vries, J-P P, Stefansson, K, Thompson, J R, de Bakker, P I, Deloukas, P, Sayers, R D, Harrison, S, van Rij, A M, Samani, N J & Bown, M J 2016, ' Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ', Circulation Research . https://doi.org/10.1161/CIRCRESAHA.116.308765
Circulation Research
Circulation Research, 120(2), 341-353. Lippincott Williams and Wilkins
Circulation Research, 120(2), 341. Lippincott Williams and Wilkins
Jones, G T, Tromp, G, Kuivaniemi, H, Gretarsdottir, S, Baas, A F, Giusti, B, Strauss, E, van 't Hof, F N, Webb, T, Erdman, R, Ritchie, M D, Elmore, J R, Verma, A, Pendergrass, S, Kullo, I J, Ye, Z, Peissig, P L, Gottesman, O, Verma, S S, Malinowski, J, Rasmussen-Torvik, L J, Borthwick, K, Smelser, D T, Crosslin, D R, de Andrade, M, Ryer, E J, McCarty, C A, Bottinger, E P, Pacheco, J A, Crawford, D C, Carrell, D S, Gerhard, G S, Franklin, D P, Carey, D J, Phillips, V L, Williams, M J, Wei, W, Blair, R, Hill, A A, Vasudevan, T M, Lewis, D R, Thomson, I A, Krysa, J, Hill, G B, Roake, J, Merriman, T R, Oszkinis, G, Galora, S, Saracini, C, Abbate, R, Pulli, R, Pratesi, C, Saratzis, A, Verissimo, A, Bumpstead, S J, Badger, S A, Clough, R E, Cockerill, G W, Hafez, H, Scott, D J, Futers, T S, Romaine, S P, Bridge, K, Griffin, K J, Bailey, M A, Smith, A, Thompson, M M, van Bockxmeer, F, Matthiasson, S E, Thorleifsson, G, Thorsteinsdottir, U, Blankensteijn, J D, Teijink, J A, Wijmenga, C, de Graaf, J, Kiemeney, L A, Lindholt, J S, Hughes, A E, Bradley, D T, Stirrups, K, Golledge, J, Norman, P E, Powell, J T, Humphries, S E, Hamby, S E, Goodall, A H, Nelson, C P, Sakalihasan, N, Courtois, A, Ferrell, R E, Eriksson, P, Folkersen, L, Franco-Cereceda, A, Eicher, J D, Johnson, A D, Betsholtz, C, Ruusalepp, A, Franzén, O, Schadt, E, Björkegren, J L, Lipovich, L, Drolet, A M, Verhoeven, E, Zeebregts, C J, Geelkerken, R H, van Sambeek, M R, van Sterkenburg, S M, de Vries, J-P P, Stefansson, K, Thompson, J R, de Bakker, P I, Deloukas, P, Sayers, R D, Harrison, S, van Rij, A M, Samani, N J & Bown, M J 2017, ' Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ', Circulation Research, vol. 120, no. 2, pp. 341-353 . https://doi.org/10.1161/CIRCRESAHA.116.308765
Jones, G T, Tromp, G, Kuivaniemi, H, Gretarsdottir, S, Baas, A F, Giusti, B, Strauss, E, Van'T Hof, F N G, Webb, T R, Erdman, R, Ritchie, M D, Elmore, J R, Verma, A, Pendergrass, S, Kullo, I J, Ye, Z, Peissig, P L, Gottesman, O, Verma, S S, Malinowski, J, Rasmussen-Torvik, L J, Borthwick, K M, Smelser, DI T, Crosslin, D R, De Andrade, M, Ryer, E J, McCarty, C A, Böttinger, E P, Pacheco, J A, Crawford, D C, Carrell, D S, Gerhard, G S, Franklin, D P, Carey, D J, Phillips, V L, Williams, M J A, Wei, W, Blair, R, Hill, A A, Vasudevan, T M, Lewis, D R, Thomson, I A, Krysa, J, Hill, G B, Roake, J, Merriman, T R, Oszkinis, G, Galora, S, Saracini, C, Abbate, R, Pulli, R, Pratesi, C, Saratzis, A, Verissimo, A R, Bumpstead, S, Badger, S A, Clough, R E, Cockerill, G, Hafez, H, Scott, D J A, Futers, T S, Romaine, S P R, Bridge, K, Griffin, K J, Bailey, M A, Smith, A, Thompson, M M, Van Bockxmeer, F M, Matthiasson, S E, Thorleifsson, G, Thorsteinsdottir, U, Blankensteijn, J D, Teijink, J A W, Wijmenga, C, De Graaf, J, Kiemeney, L A, Lindholt, J S, Hughes, A, Bradley, D T, Stirrups, K, Golledge, J, Norman, P E, Powell, J T, Humphries, S E, Hamby, S E, Goodall, A H, Nelson, C P, Sakalihasan, N, Courtois, A, Ferrell, R E, Eriksson, P, Folkersen, L, Franco-Cereceda, A, Eicher, J D, Johnson, A D, Betsholtz, C, Ruusalepp, A, Franzén, O, Schadt, E E, Björkegren, J L M, Lipovich, L, Drolet, A M, Verhoeven, E L, Zeebregts, C J, Geelkerken, R H, Van Sambeek, M R, Van Sterkenburg, S M, De Vries, J P, Stefansson, K, Thompson, J R, De Bakker, P I W, Deloukas, P, Sayers, R D, Harrison, S C, Van Rij, A M, Samani, N J & Bown, M J 2017, ' Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ', Circulation Research, vol. 120, no. 2, pp. 341-353 . https://doi.org/10.1161/CIRCRESAHA.116.308765
Jones, G T, Tromp, G, Kuivaniemi, H, Gretarsdottir, S, Baas, A F, Giusti, B, Strauss, E, Van't Hof, F N G, Webb, T R, Erdman, R, Ritchie, M D, Elmore, J R, Verma, A, Pendergrass, S, Kullo, I J, Ye, Z, Peissig, P L, Gottesman, O, Verma, S S, Malinowski, J, Rasmussen-Torvik, L J, Borthwick, K M, Smelser, D T, Crosslin, D R, de Andrade, M, Ryer, E J, McCarty, C A, Böttinger, E P, Pacheco, J A, Crawford, D C, Carrell, D S, Gerhard, G S, Franklin, D P, Carey, D J, Phillips, V L, Williams, M J A, Wei, W, Blair, R, Hill, A A, Vasudevan, T M, Lewis, D R, Thomson, I A, Krysa, J, Hill, G B, Roake, J, Merriman, T R, Oszkinis, G, Galora, S, Saracini, C, Abbate, R, Pulli, R, Pratesi, C, Saratzis, A, Verissimo, A R, Bumpstead, S, Badger, S A, Clough, R E, Cockerill, G, Hafez, H, Scott, D J A, Futers, T S, Romaine, S P R, Bridge, K, Griffin, K J, Bailey, M A, Smith, A, Thompson, M M, van Bockxmeer, F M, Matthiasson, S E, Thorleifsson, G, Thorsteinsdottir, U, Blankensteijn, J D, Teijink, J A W, Wijmenga, C, de Graaf, J, Kiemeney, L A, Lindholt, J S, Hughes, A, Bradley, D T, Stirrups, K, Golledge, J, Norman, P E, Powell, J T, Humphries, S E, Hamby, S E, Goodall, A H, Nelson, C P, Sakalihasan, N, Courtois, A, Ferrell, R E, Eriksson, P, Folkersen, L, Franco-Cereceda, A, Eicher, J D, Johnson, A D, Betsholtz, C, Ruusalepp, A, Franzén, O, Schadt, E E, Björkegren, J L M, Lipovich, L, Drolet, A M, Verhoeven, E L, Zeebregts, C J, Geelkerken, R H, van Sambeek, M R, van Sterkenburg, S M, de Vries, J P P M, Stefansson, K, Thompson, J R, de Bakker, P I W, Deloukas, P, Sayers, R D, Harrison, S C, van Rij, A M, Samani, N J & Bown, M J 2017, ' Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ', Circulation Research, vol. 120, no. 2, pp. 341-353 . https://doi.org/10.1161/CIRCRESAHA.116.308765

Supplemental Digital Content is available in the text.
Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9765246dbee9fe88e574a6fb66b1fbdf
https://pure.qub.ac.uk/en/publications/28db45a5-0dcb-4669-93d7-d1bc1c916b0f

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

Autor: Jones GT; For the author affiliations, please see the Appendix. m.bown@le.ac.uk greg.jones@otago.ac.nz., Tromp G; For the author affiliations, please see the Appendix., Kuivaniemi H; For the author affiliations, please see the Appendix., Gretarsdottir S; For the author affiliations, please see the Appendix., Baas AF; For the author affiliations, please see the Appendix., Giusti B; For the author affiliations, please see the Appendix., Strauss E; For the author affiliations, please see the Appendix., Van't Hof FN; For the author affiliations, please see the Appendix., Webb TR; For the author affiliations, please see the Appendix., Erdman R; For the author affiliations, please see the Appendix., Ritchie MD; For the author affiliations, please see the Appendix., Elmore JR; For the author affiliations, please see the Appendix., Verma A; For the author affiliations, please see the Appendix., Pendergrass S; For the author affiliations, please see the Appendix., Kullo IJ; For the author affiliations, please see the Appendix., Ye Z; For the author affiliations, please see the Appendix., Peissig PL; For the author affiliations, please see the Appendix., Gottesman O; For the author affiliations, please see the Appendix., Verma SS; For the author affiliations, please see the Appendix., Malinowski J; For the author affiliations, please see the Appendix., Rasmussen-Torvik LJ; For the author affiliations, please see the Appendix., Borthwick KM; For the author affiliations, please see the Appendix., Smelser DT; For the author affiliations, please see the Appendix., Crosslin DR; For the author affiliations, please see the Appendix., de Andrade M; For the author affiliations, please see the Appendix., Ryer EJ; For the author affiliations, please see the Appendix., McCarty CA; For the author affiliations, please see the Appendix., Böttinger EP; For the author affiliations, please see the Appendix., Pacheco JA; For the author affiliations, please see the Appendix., Crawford DC; For the author affiliations, please see the Appendix., Carrell DS; For the author affiliations, please see the Appendix., Gerhard GS; For the author affiliations, please see the Appendix., Franklin DP; For the author affiliations, please see the Appendix., Carey DJ; For the author affiliations, please see the Appendix., Phillips VL; For the author affiliations, please see the Appendix., Williams MJ; For the author affiliations, please see the Appendix., Wei W; For the author affiliations, please see the Appendix., Blair R; For the author affiliations, please see the Appendix., Hill AA; For the author affiliations, please see the Appendix., Vasudevan TM; For the author affiliations, please see the Appendix., Lewis DR; For the author affiliations, please see the Appendix., Thomson IA; For the author affiliations, please see the Appendix., Krysa J; For the author affiliations, please see the Appendix., Hill GB; For the author affiliations, please see the Appendix., Roake J; For the author affiliations, please see the Appendix., Merriman TR; For the author affiliations, please see the Appendix., Oszkinis G; For the author affiliations, please see the Appendix., Galora S; For the author affiliations, please see the Appendix., Saracini C; For the author affiliations, please see the Appendix., Abbate R; For the author affiliations, please see the Appendix., Pulli R; For the author affiliations, please see the Appendix., Pratesi C; For the author affiliations, please see the Appendix., Saratzis A; For the author affiliations, please see the Appendix., Verissimo AR; For the author affiliations, please see the Appendix., Bumpstead S; For the author affiliations, please see the Appendix., Badger SA; For the author affiliations, please see the Appendix., Clough RE; For the author affiliations, please see the Appendix., Cockerill G; For the author affiliations, please see the Appendix., Hafez H; For the author affiliations, please see the Appendix., Scott DJ; For the author affiliations, please see the Appendix., Futers TS; For the author affiliations, please see the Appendix., Romaine SP; For the author affiliations, please see the Appendix., Bridge K; For the author affiliations, please see the Appendix., Griffin KJ; For the author affiliations, please see the Appendix., Bailey MA; For the author affiliations, please see the Appendix., Smith A; For the author affiliations, please see the Appendix., Thompson MM; For the author affiliations, please see the Appendix., van Bockxmeer FM; For the author affiliations, please see the Appendix., Matthiasson SE; For the author affiliations, please see the Appendix., Thorleifsson G; For the author affiliations, please see the Appendix., Thorsteinsdottir U; For the author affiliations, please see the Appendix., Blankensteijn JD; For the author affiliations, please see the Appendix., Teijink JA; For the author affiliations, please see the Appendix., Wijmenga C; For the author affiliations, please see the Appendix., de Graaf J; For the author affiliations, please see the Appendix., Kiemeney LA; For the author affiliations, please see the Appendix., Lindholt JS; For the author affiliations, please see the Appendix., Hughes A; For the author affiliations, please see the Appendix., Bradley DT; For the author affiliations, please see the Appendix., Stirrups K; For the author affiliations, please see the Appendix., Golledge J; For the author affiliations, please see the Appendix., Norman PE; For the author affiliations, please see the Appendix., Powell JT; For the author affiliations, please see the Appendix., Humphries SE; For the author affiliations, please see the Appendix., Hamby SE; For the author affiliations, please see the Appendix., Goodall AH; For the author affiliations, please see the Appendix., Nelson CP; For the author affiliations, please see the Appendix., Sakalihasan N; For the author affiliations, please see the Appendix., Courtois A; For the author affiliations, please see the Appendix., Ferrell RE; For the author affiliations, please see the Appendix., Eriksson P; For the author affiliations, please see the Appendix., Folkersen L; For the author affiliations, please see the Appendix., Franco-Cereceda A; For the author affiliations, please see the Appendix., Eicher JD; For the author affiliations, please see the Appendix., Johnson AD; For the author affiliations, please see the Appendix., Betsholtz C; For the author affiliations, please see the Appendix., Ruusalepp A; For the author affiliations, please see the Appendix., Franzén O; For the author affiliations, please see the Appendix., Schadt EE; For the author affiliations, please see the Appendix., Björkegren JL; For the author affiliations, please see the Appendix., Lipovich L; For the author affiliations, please see the Appendix., Drolet AM; For the author affiliations, please see the Appendix., Verhoeven EL; For the author affiliations, please see the Appendix., Zeebregts CJ; For the author affiliations, please see the Appendix., Geelkerken RH; For the author affiliations, please see the Appendix., van Sambeek MR; For the author affiliations, please see the Appendix., van Sterkenburg SM; For the author affiliations, please see the Appendix., de Vries JP; For the author affiliations, please see the Appendix., Stefansson K; For the author affiliations, please see the Appendix., Thompson JR; For the author affiliations, please see the Appendix., de Bakker PI; For the author affiliations, please see the Appendix., Deloukas P; For the author affiliations, please see the Appendix., Sayers RD; For the author affiliations, please see the Appendix., Harrison SC; For the author affiliations, please see the Appendix., van Rij AM; For the author affiliations, please see the Appendix., Samani NJ; For the author affiliations, please see the Appendix., Bown MJ; For the author affiliations, please see the Appendix. m.bown@le.ac.uk greg.jones@otago.ac.nz.

Publikováno v: Circulation research [Circ Res] 2017 Jan 20; Vol. 120 (2), pp. 341-353. Date of Electronic Publication: 2016 Nov 29.