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Akademický článek

Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases

Autor: Joakim W Karlsson, Vasu R Sah, Roger Olofsson Bagge, Irina Kuznetsova, Munir Iqba, Samuel Alsen, Sofia Stenqvist, Alka Saxena, Lars Ny, Lisa M Nilsson, Jonas A Nilsson

Publikováno v: eLife, Vol 12 (2024)

Uveal melanoma (UM) is a rare melanoma originating in the eye’s uvea, with 50% of patients experiencing metastasis predominantly in the liver. In contrast to cutaneous melanoma, there is only a limited effectiveness of combined immune checkpoint th

Externí odkaz: https://doaj.org/article/c4cf816d012540229735b294db77459e

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Akademický článek

Cancer stem cells are prevalent in the basal-like 2 and mesenchymal triple-negative breast cancer subtypes in vitro

Autor: Maxim Olsson, Peter Larsson, Junko Johansson, Vasu R. Sah, Toshima Z. Parris

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with the most unfavorable clinical outcomes, in part due to tumor heterogeneity, treatment resistance, and tumor relapse. The TNBC subtypes [basal-like 1 (BL1), basal-like 2 (B

Externí odkaz: https://doaj.org/article/cc89dfb3e78e40f3886ef428e2aabab0

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Akademický článek

The PEMDAC phase 2 study of pembrolizumab and entinostat in patients with metastatic uveal melanoma

Autor: Lars Ny, Henrik Jespersen, Joakim Karlsson, Samuel Alsén, Stefan Filges, Charlotta All-Eriksson, Bengt Andersson, Ana Carneiro, Hildur Helgadottir, Max Levin, Ingrid Ljuslinder, Roger Olofsson Bagge, Vasu R. Sah, Ulrika Stierner, Anders Ståhlberg, Gustav Ullenhag, Lisa M. Nilsson, Jonas A. Nilsson

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

The authors report the results of the phase II PEMDAC clinical study testing the combination of the HDAC inhibitor entinostat with the anti- PD-1 antibody pembrolizumab in uveal melanoma. Low tumor burden, a wildtype BAP1 gene in the tumor or iris me

Externí odkaz: https://doaj.org/article/81ef06cf1a674812b72c3509644a228b

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Akademický článek

Molecular profiling of driver events in metastatic uveal melanoma

Autor: Joakim Karlsson, Lisa M. Nilsson, Suman Mitra, Samuel Alsén, Ganesh Vilas Shelke, Vasu R. Sah, Elin M. V. Forsberg, Ulrika Stierner, Charlotta All-Eriksson, Berglind Einarsdottir, Henrik Jespersen, Lars Ny, Per Lindnér, Erik Larsson, Roger Olofsson Bagge, Jonas A. Nilsson

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

The genetics of uveal melanoma has mainly been studied in primary tumours. In this study, the authors perform whole genome sequencing as well as immune cell profiling of biopsy samples obtained from metastatic uveal melanoma patients, providing an up

Externí odkaz: https://doaj.org/article/f71cb61f5c524059bea90c9e29676365

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