Guidelines for minimal information on cellular senescence experimentation in vivo.

Autor: Ogrodnik M; Ludwig Boltzmann Research Group Senescence and Healing of Wounds, 1200 Vienna, Austria; Ludwig Boltzmann Institute for Traumatology, The Research Centre in Cooperation with AUVA, 1200 Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria. Electronic address: mikolaj.ogrodnik@lbg.ac.at., Carlos Acosta J; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, UK; Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC (CSIC, Universidad de Cantabria), C/ Albert Einstein 22, 39011 Santander, Spain., Adams PD; Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., d'Adda di Fagagna F; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy; Institute of Molecular Genetics IGM-CNR 'Luigi Luca Cavalli-Sforza,' Pavia, Italy., Baker DJ; Department of Biochemistry and Molecular Biology, Department of Pediatric and Adolescent Medicine, Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Steet SW, Rochester, MN 55905, USA., Bishop CL; Blizard Institute, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK., Chandra T; MRC Human Generics Unit, University of Edinburgh, Edinburgh, UK., Collado M; Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain; Department of Immunology and Oncology (DIO), Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain., Gil J; MRC Laboratory of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK., Gorgoulis V; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece; Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece; Ninewells Hospital and Medical School, University of Dundee, Dundee DD19SY, UK; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M20 4GJ, UK; Faculty of Health and Medical Sciences, University of Surrey, Surrey GU2 7YH, UK., Gruber F; Department of Dermatology, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Skin Multimodal Imaging of Aging and Senescence - SKINMAGINE, Vienna, Austria., Hara E; Research Institute for Microbial Diseases (RIMD), Osaka University, Suita 565-0871, Japan; Immunology Frontier Research Center (IFReC), Osaka University, Suita 565-0871, Japan., Jansen-Dürr P; Institute for Biomedical Aging Research, University of Innsbruck, and Center for Molecular Biosciences Innsbruck (CMBI), Innsbruck, Austria., Jurk D; Mayo Clinic, Department of Physiology and Biomedical Engineering, Robert and Arlene Kogod Center on Aging, Rochester, MN, USA., Khosla S; Kogod Center on Aging and Division of Endocrinology, Mayo Clinic, Rochester, MN, USA., Kirkland JL; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA., Krizhanovsky V; Department of Molecular Cell Biology, The Weizmann Institute of Science, 7610001 Rehovot, Israel., Minamino T; Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan., Niedernhofer LJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6-155 Jackson Hall, 321 Church Street, SE, Minneapolis, MN 55455, USA., Passos JF; Mayo Clinic, Department of Physiology and Biomedical Engineering, Robert and Arlene Kogod Center on Aging, Rochester, MN, USA., Ring NAR; Ludwig Boltzmann Research Group Senescence and Healing of Wounds, 1200 Vienna, Austria; Ludwig Boltzmann Institute for Traumatology, The Research Centre in Cooperation with AUVA, 1200 Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria., Redl H; Ludwig Boltzmann Research Group Senescence and Healing of Wounds, 1200 Vienna, Austria; Ludwig Boltzmann Institute for Traumatology, The Research Centre in Cooperation with AUVA, 1200 Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria., Robbins PD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6-155 Jackson Hall, 321 Church Street, SE, Minneapolis, MN 55455, USA., Rodier F; Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; Institut du cancer de Montréal, Montreal, QC, Canada; Université de Montréal, Département de radiologie, radio-oncologie et médicine nucléaire, Montreal, QC, Canada., Scharffetter-Kochanek K; Department f Dermatology and Allergic Diseases, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany., Sedivy JM; Department of Molecular, Cellular Biology and Biochemistry, Center on the Biology of Aging, Brown University, Providence, RI, USA., Sikora E; Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland., Witwer K; The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA; The Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA., von Zglinicki T; Newcastle University Biosciences Institute, Ageing Biology Laboratories, Newcastle upon Tyne, UK., Yun MH; Technische Universität Dresden, CRTD/Center for Regenerative Therapies Dresden, Dresden, Germany; Max Planck Institute of Molecular Cellular Biology and Genetics, Dresden, Germany; Physics of Life Excellence Cluster, Dresden, Germany., Grillari J; Ludwig Boltzmann Institute for Traumatology, The Research Centre in Cooperation with AUVA, 1200 Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria; Institute of Molecular Biotechnology, BOKU University, Vienna, Austria. Electronic address: johannes.grillari@lbg.ac.at., Demaria M; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen (RUG), Groningen, the Netherlands. Electronic address: m.demaria@umcg.nl.

Publikováno v: Cell [Cell] 2024 Aug 08; Vol. 187 (16), pp. 4150-4175.

Decoding of translation-regulating entities reveals heterogeneous translation deficiency patterns in cellular senescence.

Autor: Papaspyropoulos A; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens (NKUA), Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece., Hazapis O; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens (NKUA), Athens, Greece., Altulea A; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, The Netherlands., Polyzou A; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens (NKUA), Athens, Greece., Verginis P; Medical School, University of Crete, Heraklion, Greece., Evangelou K; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens (NKUA), Athens, Greece., Fousteri M; Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece., Papantonis A; Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Demaria M; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, The Netherlands., Gorgoulis V; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens (NKUA), Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece.; Clinical Molecular Pathology, Medical School, University of Dundee, Dundee, UK.; Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.

Publikováno v: Aging cell [Aging Cell] 2023 Sep; Vol. 22 (9), pp. e13893. Date of Electronic Publication: 2023 Aug 07.

Interplay of Developmental Hippo-Notch Signaling Pathways with the DNA Damage Response in Prostate Cancer.

Autor: Mourkioti I; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece., Angelopoulou A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece., Belogiannis K; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece., Lagopati N; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.; Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece., Potamianos S; First ENT Department, Hippocration Hospital, University of Athens, 11527 Athens, Greece., Kyrodimos E; First ENT Department, Hippocration Hospital, University of Athens, 11527 Athens, Greece., Gorgoulis V; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.; Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.; Clinical Molecular Pathology, Medical School, University of Dundee, Dundee DD1 9SY, UK.; Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M20 4GJ, UK.; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.; Faculty of Health and Medical Sciences, University of Surrey, Surrey GU2 7YH, UK., Papaspyropoulos A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.; Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.

Publikováno v: Cells [Cells] 2022 Aug 07; Vol. 11 (15). Date of Electronic Publication: 2022 Aug 07.

Inhaled corticosteroids reduce senescence in endothelial progenitor cells from patients with COPD.

Autor: Paschalaki K; National Heart and Lung Institute, Imperial College London, London, UK k.paschalaki@imperial.ac.uk., Rossios C; National Heart and Lung Institute, Imperial College London, London, UK., Pericleous C; National Heart and Lung Institute, Imperial College London, London, UK., MacLeod M; National Heart and Lung Institute, Imperial College London, London, UK., Rothery S; National Heart and Lung Institute, Imperial College London, London, UK., Donaldson GC; National Heart and Lung Institute, Imperial College London, London, UK., Wedzicha JA; National Heart and Lung Institute, Imperial College London, London, UK., Gorgoulis V; Department of Histology and Embryology, National and Kapodistrian University of Athens, Athens, Attica, Greece.; Biomedical Research Foundation of the Academy of Athens, Athens, Attica, Greece.; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens School of Medicine, Athens, Attica, Greece.; Faculty Institute for Cancer Sciences, Manchester Academic Health Science Centre, Manchester, UK., Randi AM; National Heart and Lung Institute, Imperial College London, London, UK., Barnes PJ; National Heart and Lung Institute, Imperial College London, London, UK.

Publikováno v: Thorax [Thorax] 2022 Jun; Vol. 77 (6), pp. 616-620. Date of Electronic Publication: 2022 Jan 13.

RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1.

Autor: Papaspyropoulos A; Department of Oncology, University of Oxford, Oxford, UK.; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens (NKUA), Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece., Angelopoulou A; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens (NKUA), Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece., Mourkioti I; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens (NKUA), Athens, Greece., Polyzou A; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens (NKUA), Athens, Greece., Pankova D; Department of Oncology, University of Oxford, Oxford, UK., Toskas K; Department of Oncology, University of Oxford, Oxford, UK., Lanfredini S; Department of Oncology, University of Oxford, Oxford, UK., Pantazaki AA; Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece., Lagopati N; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens (NKUA), Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece., Kotsinas A; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens (NKUA), Athens, Greece., Evangelou K; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens (NKUA), Athens, Greece., Chronopoulos E; Laboratory for Research of the Musculoskeletal System, KAT General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., O'Neill E; Department of Oncology, University of Oxford, Oxford, UK., Gorgoulis V; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens (NKUA), Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece.; Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.

Publikováno v: EMBO reports [EMBO Rep] 2022 Feb 03; Vol. 23 (2), pp. e51287. Date of Electronic Publication: 2021 Dec 13.