Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Vassilis Pachnis"'
Autor:
Anna Laddach, Song Hui Chng, Reena Lasrado, Fränze Progatzky, Michael Shapiro, Alek Erickson, Marisol Sampedro Castaneda, Artem V. Artemov, Ana Carina Bon-Frauches, Eleni-Maria Amaniti, Jens Kleinjung, Stefan Boeing, Sila Ultanir, Igor Adameyko, Vassilis Pachnis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Glial cells have been proposed as a source of neural progenitors, but the mechanisms underpinning the neurogenic potential of adult glia are not known. Using single cell transcriptomic profiling, we show that enteric glial cells represent a
Externí odkaz:
https://doaj.org/article/86392e391ca64dc18dbed188143dce59
Autor:
Zeinab Asgarian, Marcio Guiomar Oliveira, Agata Stryjewska, Ioannis Maragkos, Anna Noren Rubin, Lorenza Magno, Vassilis Pachnis, Mohammadmersad Ghorbani, Scott Wayne Hiebert, Myrto Denaxa, Nicoletta Kessaris
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
There is a large diversity of inhibitory interneurons in the mammalian cerebral cortex. How this emerges during embryogenesis remains unclear. Here, the authors identify MTG8 as a co-factor of LHX6 and a new regulator of cortical interneuron developm
Externí odkaz:
https://doaj.org/article/00979fa66fb446ab972a14461acf5a6a
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
The majority of the enteric nervous system is formed by vagal neural crest cells which enter the foregut and migrate rostrocaudally to colonise the entire length of the gastrointestinal tract. Absence of enteric ganglia from the distal colon are the
Externí odkaz:
https://doaj.org/article/90a1becfe01a41e4a2a7270842134406
Autor:
Sarah McCallum, Yuuki Obata, Evangelia Fourli, Stefan Boeing, Christopher J Peddie, Qiling Xu, Stuart Horswell, Robert N Kelsh, Lucy Collinson, David Wilkinson, Carmen Pin, Vassilis Pachnis, Tiffany A Heanue
Publikováno v:
eLife, Vol 9 (2020)
The presence and identity of neural progenitors in the enteric nervous system (ENS) of vertebrates is a matter of intense debate. Here, we demonstrate that the non-neuronal ENS cell compartment of teleosts shares molecular and morphological character
Externí odkaz:
https://doaj.org/article/2e57d2f002cf475ba4153d7c9abee0b6
Autor:
Myrto Denaxa, Guilherme Neves, Adam Rabinowitz, Sarah Kemlo, Petros Liodis, Juan Burrone, Vassilis Pachnis
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1710-1721 (2018)
Summary: Cortical networks are composed of excitatory projection neurons and inhibitory interneurons. Finding the right balance between the two is important for controlling overall cortical excitation and network dynamics. However, it is unclear how
Externí odkaz:
https://doaj.org/article/49f5b96f62204f9e86818600b43f81e9
Publikováno v:
Journal of Experimental Neuroscience, Vol 12 (2018)
The mammalian cortex consists of two main neuronal types: the principal excitatory pyramidal neurons (PNs) and the inhibitory interneurons (INs). The interplay between these two neuronal populations – which drive excitation and inhibition (E/I bala
Externí odkaz:
https://doaj.org/article/5eebdef30a6c4027b1e472f9027c1325
Autor:
Tiffany A Heanue, Werend Boesmans, Donald M Bell, Koichi Kawakami, Pieter Vanden Berghe, Vassilis Pachnis
Publikováno v:
PLoS Genetics, Vol 12, Iss 11, p e1006439 (2016)
Hirschsprung disease (HSCR) is characterized by absence of enteric neurons from the distal colon and severe intestinal dysmotility. To understand the pathophysiology and genetics of HSCR we developed a unique zebrafish model that allows combined gene
Externí odkaz:
https://doaj.org/article/1fb37f9316e949369f6a56a009dfa865
Autor:
Myrto Denaxa, Melanie Kalaitzidou, Anna Garefalaki, Angeliki Achimastou, Reena Lasrado, Tamara Maes, Vassilis Pachnis
Publikováno v:
Cell Reports, Vol 2, Iss 5, Pp 1351-1362 (2012)
The generation of cortical interneuron subtypes is controlled by genetic programs that are activated in the ventral forebrain and unfold during the prolonged period of inhibitory neuron development. The LIM-homeodomain protein LHX6 is critical for th
Externí odkaz:
https://doaj.org/article/8c67c2f0f7a040fb8a505c423a8b189b
Autor:
Afonso Rocha Martins Almeida, Sílvia Arroz-Madeira, Diogo Fonseca-Pereira, Hélder Ribeiro, Reena Lasrado, Vassilis Pachnis, Henrique Veiga-Fernandes
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52949 (2012)
Identification of thymocyte regulators is a central issue in T cell biology. Interestingly, growing evidence indicates that common key molecules control neuronal and immune cell functions. The neurotrophic factor receptor RET mediates critical functi
Externí odkaz:
https://doaj.org/article/c67d4d5bf25a49f6a39e1b2668a4a86f
Autor:
Vassilis Pachnis, Anna Laddach, Song Hui Chng, Reena Lasrado, Franze Progatzky, Michael Shapiro, Alek Erickson, Marisol Sampedro-Castaneda, Artem Artemov, Ana Carina Bon-Frauches, Jens Kleinjung, Stefan Boeing, Sila Ultanir, Igor Adameyko, Eleni-Maria Amaniti
Development of the nervous system is underpinned by changes in gene expression and chromatin configuration during embryogenesis and early postnatal life. To uncover the molecular mechanisms orchestrating cell lineage differentiation and maturation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29d0596ea135acb1470c0c5693777e91
https://doi.org/10.21203/rs.3.rs-2491905/v1
https://doi.org/10.21203/rs.3.rs-2491905/v1