Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Vassilis J. Demopoulos"'
Publikováno v:
Molbank, Vol 2022, Iss 4, p M1471 (2022)
1-Phenyl-3-tosyl-1H-pyrrole was prepared, in moderate yield, by the electrophilic aromatic substitution of 1-phenyl-1H-pyrrole with tosyl chloride in the presence of excess zinc oxide under solvent-free conditions. A minor product was its isomer, 1-p
Externí odkaz:
https://doaj.org/article/03d163ea46a142b3805d733b5fa94333
Autor:
Sofia K. Georgiou-Siafis, Martina K. Samiotaki, Vassilis J. Demopoulos, George Panayotou, Asterios S. Tsiftsoglou
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1959 (2022)
Hemin, an oxidized form of heme, acts as potent oxidant to regulate glutathione (GSH) content in pro-erythroid K562 nucleated cells, via activation of the KEAP1/NRF2 defensive signaling pathway. Moreover, GSH, as an essential metabolite, is involved
Externí odkaz:
https://doaj.org/article/ed316448150d4603a2fa23b813692c4a
Publikováno v:
ADMET and DMPK, Vol 9, Iss 3 (2021)
ADMET and DMPK
Volume 9
Issue 3
ADMET and DMPK
Volume 9
Issue 3
Fraction Lipophicity Index (FLI) has been developed as a composite drug-like metric combining logP and logD in a weighted manner. In the present study an extended data set confirmed the previously established drug-like FLI range 0-8 using two calcula
Publikováno v:
Organic Preparations and Procedures International. 51:147-152
The aroyl-1-aryl-1H-pyrrole moiety is an important scaffold present in a number of biologically active compounds.1–5 Based on such precedent, we were prompted to study the electrophilic benzoylatio...
Autor:
George Panayotou, Martina Samiotaki, Asterios S. Tsiftsoglou, Sofia K. Georgiou-Siafis, Vassilis J. Demopoulos
Publikováno v:
European journal of pharmacology. 880
Heme (iron protoporphyrin IX), as the prosthetic group in hemoproteins, regulates vital cellular functions in human tissues. However, free heme released during hemolysis events promotes severe complications to millions of people worldwide. Over the y
Publikováno v:
Synthetic Communications. 43:2949-2954
A facile Clauson–Kaas-type pyrrolyl-phenol synthesis has been achieved in the presence of nicotinamide, which is inexpensive and nontoxic. The starting material is aminophenol hydrochloride. This is advantageous in certain cases because it is the o
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:869-873
Seven novel ARIs (3a-c, 4a-c and 5) were synthesized with the implementation of an optimized and, partially, selective synthetic procedure, via a Friedel-Crafts acylation reaction. The synthesized ARIs have values of IC(50)(ALR2) ranging from 0.19μM
Publikováno v:
Expert Opinion on Therapeutic Patents. 22:1303-1323
Initially studied for its central role in the pathogenesis of chronic diabetic complications, aldose reductase (ALR2) gains more attention over the years as its implication in inflammatory diseases is being established, along with the therapeutic pot
Autor:
Marios Chrysanthakopoulos, Ioannis Nicolaou, Anna Tsantili-Kakoulidou, Vassilis J. Demopoulos
Publikováno v:
Journal of Planar Chromatography – Modern TLC. 25:349-354
The lipophilicity of a series of pyrrolyl-acetic acid derivatives, inhibitors of the aldose reductase enzyme, was assessed by reversedphase thin layer chromatography (RP-TLC). The role of the carbon content of the stationary phase in reproducing the