Výsledky vyhledávání - "Vassilis Atsaves"

The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK+ anaplastic large cell lymphoma

Autor: Dan Jones, L. Jeffrey Medeiros, Chryssoula Liakou, Efstratios Patsouris, Elias Drakos, Lazaros Lekakis, Vasiliki Leventaki, George E. Baltatzis, Dimitris Chioureas, George Z. Rassidakis, Marianna Feretzaki, Francois Xavier Claret, Mehran Ghaderi, Panayiotis Panayiotidis, Vassilis Atsaves, Vassilis G. Gorgoulis

Publikováno v: British Journal of Haematology. 167:514-523

Anaplastic lymphoma kinase (ALK)+ anaplastic large cell lymphoma (ALCL) frequently carries the t(2;5)(p23;q35) resulting in expression of NPM1(NPM)-ALK oncogenic kinase. The latter is capable of activating ERK kinase, which upregulates JUNB expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfca08c3cb68e9d9c5c1e9af6aa9488
https://doi.org/10.1111/bjh.13079

Zobrazit plný text záznamu

Foamy Virus Based Vectors for CAR-T Cell Development

Autor: Ioannis Tsironis, George Vassilopoulos, Margarita Gkyzi, Emmanouil Simantirakis, Vassilis Atsaves, Kostas Konstantopoulos

Publikováno v: Blood. 134:4646-4646

Introduction A novel approach that can cover the therapeutic gap in NHL treatment are the autologous T cells, expressing Chimeric Antigen Receptors (CAR-T cells) against tumor markers. Such clinical-grade products based on Lenti (LV) or Retro- vector

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62d743acc855ccf9f5d6290121e5cf26
https://doi.org/10.1182/blood-2019-123022

Zobrazit plný text záznamu

Expression patterns of endothelin-1 and its receptors in colorectal cancer

Autor: Nikolaos Roidis, Vassilis Atsaves, Anastasios E. Germenis, George Z. Rassidakis, Vasiliki Leventaki, Kostantinos Tepetes, Paraskevi Liakou, Konstantinos Hatzitheophilou, Efstratios Patsouris

Publikováno v: Journal of Surgical Oncology. 105:643-649

Background and Objectives Endothelin-1 (ET-1), a potent vasoconstricting peptide, plays an important role in carcinogenesis. Previous in vitro studies have shown that colorectal cancer cells produce ET-1. Methods ET-1 and its receptors ET-A (ETAR) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0dd29c37377b8723e6ef659699f39f7
https://doi.org/10.1002/jso.23017

Zobrazit plný text záznamu

Genetic Basis, Expression Patterns and Clinical Significance of PD-L1 in Peripheral T-Cell Lymphomas (PTCL)

Autor: Nikolaos Tsesmetzis, Vassilis Atsaves, Georgia Kokaraki, Pedro Farrajota Neves Da Silva, Anders Österborg, George Z. Rassidakis

Publikováno v: Blood. 132:2868-2868

Introduction: The PD-1 / PD-L1 interaction is a crucial immune checkpoint in cancer, which has been targeted by monoclonal antibodies currently used in clinical trials. The genetic basis and transcriptional regulation of PD-L1 has been previously inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01b43e912591de133f1127a98281023c
https://doi.org/10.1182/blood-2018-99-120036

Zobrazit plný text záznamu

The helix-loop-helix protein Id2 is expressed differentially and induced by myc in T-cell lymphomas

Autor: Vasiliki Leventaki, Dan Jones, Ellen J. Schlette, Athina Vidaki, Claudiu V. Cotta, George Z. Rassidakis, Vassilis Atsaves, L. Jeffrey Medeiros

Publikováno v: Cancer. 112:552-561

BACKGROUND. Inhibitor of DNA binding 2 (Id2), a helix-loop-helix protein of the inhibitor of differentiation (ID) family, is involved in hematopoiesis, mainly through interaction with the E-family of transcription factors. Recent studies have shown t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916b31f4386cb83ff4e0595ae5d69f89
https://doi.org/10.1002/cncr.23196

Zobrazit plný text záznamu

Expression patterns of endothelin-1 and its receptors in colorectal cancer

Autor: Paraskevi, Liakou, Kostantinos, Tepetes, Anastasios, Germenis, Vasiliki, Leventaki, Vassilis, Atsaves, Efstratios, Patsouris, Nikolaos, Roidis, Konstantinos, Hatzitheophilou, George Z, Rassidakis

Publikováno v: Journal of surgical oncology. 105(7)

Endothelin-1 (ET-1), a potent vasoconstricting peptide, plays an important role in carcinogenesis. Previous in vitro studies have shown that colorectal cancer cells produce ET-1.ET-1 and its receptors ET-A (ET(A) R) and ET-B (ET(B) R) were analyzed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ceeab780da5867fec9b5c86e1799f05
https://pubmed.ncbi.nlm.nih.gov/22213082

Zobrazit plný text záznamu

The therapeutic potential of p53 reactivation by nutlin-3a in ALK+ anaplastic large cell lymphoma with wild-type or mutated p53

Autor: L J Medeiros, Vassilis Atsaves, Ellen J. Schlette, I Papanastasi, Georgios Z. Rassidakis, Elias Drakos, Jiang Li

Publikováno v: Leukemia. 23(12)

p53 is expressed frequently, but is rarely mutated in anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) tumours. Nutlin-3a is a recently developed small molecule that targets Mdm2, a critical negative regulator of p53, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5083484bb19a90722021ea86c37f0486
https://pubmed.ncbi.nlm.nih.gov/19741726

Zobrazit plný text záznamu

Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma

Autor: L. J. Medeiros, Vasiliki Leventaki, M. Andreeff, Vassilis Atsaves, Elias Drakos, Jiang Li, Georgios Z. Rassidakis

Publikováno v: Leukemia. 23(4)

Mantle cell lymphoma (MCL) is a clinically aggressive B-cell non-Hodgkin lymphoma characterized by the t(11;14)(q13;q32) and overexpression of cyclin D1. A high proportion of MCL tumors harbor wild-type (wt) and potentially functional p53 gene. We sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21cbeda05801976dba23aae07ae3e77d
https://pubmed.ncbi.nlm.nih.gov/19225536

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání