Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19.

Autor: Zhu B; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Wei X; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Narasimhan H; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA., Qian W; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA., Zhang R; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Cheon IS; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Wu Y; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Li C; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Jones RG; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Kaplan MH; Department of Microbiology and Immunology, Indiana University of School of Medicine, Indianapolis, IN 46202, USA., Vassallo RA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA., Braciale TJ; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA., Somerville L; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA., Colca JR; Cirius Therapeutics, Kalamazoo, MI 49007, USA., Pandey A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.; Manipal Academy of Higher Education, Manipal-576 104, Karnataka, India., Jackson PEH; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA., Mann BJ; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA., Krawczyk CM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Sturek JM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA., Sun J; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.

Publikováno v: Science immunology [Sci Immunol] 2023 Apr 14; Vol. 8 (82), pp. eadf0348. Date of Electronic Publication: 2023 Apr 14.