Sphingosine 1-phosphate activation of ERM contributes to vascular calcification[S]

Autor: Claire Wilson, Samantha Borland, Thomas G. Morris, Christopher J. Clarke, Vasken Ohanian, Jacqueline Ohanian, Yusuf A. Hannun, Ann E. Canfield

Publikováno v: Journal of Lipid Research, Vol 59, Iss 1, Pp 69-78 (2018)
Morris, T, Borland, S, Clarke, C J, Wilson, C, Hannun, Y A, Ohanian, V, Canfield, A & Ohanian, J 2018, ' Sphingosine 1-phosphate activation of ERM contributes to vascular calcification ', Journal of Lipid Research, vol. 59, DOI https://doi.org/10.1194/jlr.M079731, pp. 69-78 . https://doi.org/10.1194/jlr.M079731

Vascular calcification is the deposition of mineral in the artery wall by vascular smooth muscle cells (VSMCs) in response to pathological stimuli. The process is similar to bone formation and is an independent risk factor for cardiovascular disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e7f91a83e8915945ad58f57b09e0c6
http://www.sciencedirect.com/science/article/pii/S002222752033933X

Endothelin-1 Stimulates Small Artery VCAM-1 Expression through p38MAPK-Dependent Neutral Sphingomyelinase

Autor: Vasken Ohanian, Jacqueline Ohanian, Gideon Katzenberg, Simon P. Forman

Publikováno v: Journal of Vascular Research. 49:353-362

Endothelin-1 (ET-1) stimulates vascular cell adhesion molecule (VCAM-1) expression, a process associated with arterial remodelling. However, the pathways activated by ET-1 that lead to VCAM-1 expression are not fully understood. It is reported that s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42733f9ee55caeba380a2975cf94ddb8
https://doi.org/10.1159/000336649

Role of the Actin Cytoskeleton in G-Protein–Coupled Receptor Activation of PYK2 and Paxillin in Vascular Smooth Muscle

Autor: Kelly M Gatfield, Vasken Ohanian, Jacqueline Ohanian

Publikováno v: Hypertension. 46:93-99

Dynamic remodeling of the actin cytoskeleton occurs during agonist-induced smooth muscle contraction. Tyrosine phosphorylation of the adaptor protein paxillin has been implicated in regulation of actin filament formation and force development. We hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f78a3ff29f4d07eff4bf75da47f01e
https://doi.org/10.1161/01.hyp.0000167990.82235.3c

Noradrenaline-Induced Paxillin Phosphorylation, ERK Activation and MEK-Regulated Contraction in Intact Rat Mesenteric Arteries

Autor: Vasken Ohanian, Jacqueline Ohanian, Donald T. Ward, Angela C. Alder

Publikováno v: Journal of Vascular Research. 39:1-11

In rat mesenteric arteries, noradrenaline (NA) induces a time-dependent increase in tyrosine phosphorylation of a number of proteins, one of which was identified as paxillin. NA-induced protein tyrosine phosphorylation was ablated by tyrosine kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8028944e9d6d16c07ad46cbaffd30825
https://doi.org/10.1159/000048988

Lipid second messenger regulation: the role of diacylglycerol kinases and their relevance to hypertension

Autor: Jacqueline Ohanian, Vasken Ohanian

Publikováno v: Journal of Human Hypertension. 15:93-98

Extracellular stimuli elicit cellular responses through generation of intracellular second messengers. The lipid second messenger diacylglycerol is produced following activation of the phosphoinositide signalling system. Diacylglycerol is the physiol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c909c1deaeffa9eabc30f669bc7771e5
https://doi.org/10.1038/sj.jhh.1001139