Role of Caveolin‐1 Expression in the Pathogenesis of Pulmonary Edema in Ventilator‐Induced Lung Injury

Autor: Maricela Castellon, Nikolaos A. Maniatis, Dan Hecimovich, Charalambos Roussos, David E. Schwartz, Eleftheria Letsiou, Matina Kardara, Vasily Shinin, E. Gina Votta-Vellis, Richard D. Minshall

Publikováno v: Pulmonary Circulation

Caveolin-1 is a key regulator of pulmonary endothelial barrier function. Here, we tested the hypothesis that caveolin-1 expression is required for ventilator-induced lung injury (VILI). Caveolin-1 gene-disrupted (Cav-1(-/-)) and age-, sex-, and strai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4bd106ff1e0f9716a0c736ec2dfb1e6
https://doi.org/10.4103/2045-8932.105033

Increased pulmonary vascular resistance and defective pulmonary artery filling in caveolin-1−/−mice

Autor: Stephen M. Vogel, Vasily Shinin, Nikolaos A. Maniatis, Shigenori Okada, Asrar B. Malik, Richard D. Minshall, Dean E. Schraufnagel

Publikováno v: Am J Physiol Lung Cell Mol Physiol

Caveolin-1, the structural and signaling protein of caveolae, is an important negative regulator of endothelial nitric oxide synthase (eNOS). We observed that mice lacking caveolin-1 ( Cav1−/−) had twofold increased plasma NO levels but developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec1dda5ae1a9ce07df4cf86a9f27b69
https://doi.org/10.1152/ajplung.00079.2007

Segmenting and tracking fluorescent cells in dynamic 3-D microscopy with coupled active surfaces

Autor: Jean-Christophe Olivo-Marin, Shahragim Tajbakhsh, Alexandre Dufour, N. Guillen-Aghion, Christophe Zimmer, Vasily Shinin

Publikováno v: IEEE Transactions on Image Processing
IEEE Transactions on Image Processing, 2005, 14 (9), pp.1396-410. ⟨10.1109/TIP.2005.852790⟩
IEEE Transactions on Image Processing, Institute of Electrical and Electronics Engineers, 2005, 14 (9), pp.1396-410. ⟨10.1109/TIP.2005.852790⟩

International audience; Cell migrations and deformations play essential roles in biological processes, such as parasite invasion, immune response, embryonic development, and cancer. We describe a fully automatic segmentation and tracking method desig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1eacf6205a9721fa98c30cb0c14014d
https://doi.org/10.1109/tip.2005.852790

Disturbed flow increases caveolae‐mediated oxLDL uptake in endothelial cells

Autor: Michael Cho, Elizabeth LeMaster, Richard D. Minshall, Irena Levitan, Shan Sun, David T. Eddington, Vasily Shinin

Publikováno v: The FASEB Journal. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a9f833590667280125cb39dbe0c4711
https://doi.org/10.1096/fasebj.27.1_supplement.1127.7

Caveolins and Lung Function

Autor: Olga Chernaya, Vasily Shinin, Nikolaos A. Maniatis, Richard D. Minshall

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781461412212

The primary function of the mammalian lung is to facilitate diffusion of oxygen to venous blood and to ventilate carbon dioxide produced by catabolic reactions within cells. However, it is also responsible for a variety of other important functions,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac9dff9b1877cd731d409603f189772
https://doi.org/10.1007/978-1-4614-1222-9_11