Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Vasily M, Studitsky"'
Autor:
Darya O. Koshkina, Natalya V. Maluchenko, Anna N. Korovina, Angelina A. Lobanova, Alexey V. Feofanov, Vasily M. Studitsky
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1398 (2024)
The natural polyphenol resveratrol is a biologically active compound that interacts with DNA and affects the activity of some nuclear enzymes. Its effect on the interaction between nucleosomes and poly(ADP-ribose) polymerase-1 (PARP1) and on the cata
Externí odkaz:
https://doaj.org/article/ce06b557d6d24b248cc3d7ae7cb7bb08
Autor:
Daria K. Malinina, Grigoriy A. Armeev, Olga V. Geraskina, Anna N. Korovina, Vasily M. Studitsky, Alexey V. Feofanov
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1184 (2024)
Saccharomyces cerevisiae HMO1 is an architectural nuclear DNA-binding protein that stimulates the activity of some remodelers and regulates the transcription of ribosomal protein genes, often binding to a DNA motif called IFHL. However, the molecular
Externí odkaz:
https://doaj.org/article/cf162ce9ed68484f9505afe6a5f42cee
Autor:
Anastasiia L. Sivkina, Maria G. Karlova, Maria E. Valieva, Laura L. McCullough, Timothy Formosa, Alexey K. Shaytan, Alexey V. Feofanov, Mikhail P. Kirpichnikov, Olga S. Sokolova, Vasily M. Studitsky
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
Sivkina et al. present a biochemical and biophysical characterization of the interaction of S. cerevisiae histone chaperone FACT with the nucleosome core particle. They show that FACT adopts a more open geometry in the presence of Nhp6, and together
Externí odkaz:
https://doaj.org/article/a6b17f84681e4269915f8db9da80afb0
Autor:
Olesya I. Volokh, Anastasia L. Sivkina, Andrey V. Moiseenko, Anna V. Popinako, Maria G. Karlova, Maria E. Valieva, Elena Y. Kotova, Mikhail P. Kirpichnikov, Timothy Formosa, Vasily M. Studitsky, Olga S. Sokolova
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Human FACT (FACT) is a multifunctional histone chaperone involved in transcription, replication and DNA repair. Curaxins are anticancer compounds that induce FACT-dependent nucleosome unfolding and trapping of FACT in the chromatin of cancer cells (c
Externí odkaz:
https://doaj.org/article/c3e88a4384e64cfd8196406fe7b52a80
Autor:
Daria K. Malinina, Anastasiia L. Sivkina, Anna N. Korovina, Laura L. McCullough, Tim Formosa, Mikhail P. Kirpichnikov, Vasily M. Studitsky, Alexey V. Feofanov
Publikováno v:
Cells, Vol 11, Iss 19, p 2931 (2022)
Yeast Hmo1 is a high mobility group B (HMGB) protein that participates in the transcription of ribosomal protein genes and rDNA, and also stimulates the activities of some ATP-dependent remodelers. Hmo1 binds both DNA and nucleosomes and has been pro
Externí odkaz:
https://doaj.org/article/08f01f7b34af4d3596c3feeea2140fa3
Autor:
Omar L. Kantidze, Artem V. Luzhin, Ekaterina V. Nizovtseva, Alfiya Safina, Maria E. Valieva, Arkadiy K. Golov, Artem K. Velichko, Alexander V. Lyubitelev, Alexey V. Feofanov, Katerina V. Gurova, Vasily M. Studitsky, Sergey V. Razin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Curaxins are a recently discovered class of anti-cancer agents that disturbs DNA/histone interactions within. Here the authors provide evidence that curaxins affect the spatial genome organization and compromise enhancer-promoter communication necess
Externí odkaz:
https://doaj.org/article/6ad5ed2c5629478aaf374797be05a1e6
Autor:
Han-Wen Chang, Alexey V. Feofanov, Alexander V. Lyubitelev, Grigory A. Armeev, Elena Y. Kotova, Fu-Kai Hsieh, Mikhail P. Kirpichnikov, Alexey K. Shaytan, Vasily M. Studitsky
Publikováno v:
Cells, Vol 11, Iss 16, p 2475 (2022)
Histone N-terminal tails and their post-translational modifications affect various biological processes, often in a context-specific manner; the underlying mechanisms are poorly studied. Here, the role of individual N-terminal tails of histones H2A/H
Externí odkaz:
https://doaj.org/article/93606d7b46b7459aa3494a6bed92aa5b
Autor:
Nadezhda S. Gerasimova, Olesya I. Volokh, Nikolay A. Pestov, Grigory A. Armeev, Mikhail P. Kirpichnikov, Alexey K. Shaytan, Olga S. Sokolova, Vasily M. Studitsky
Publikováno v:
Cells, Vol 11, Iss 17, p 2678 (2022)
Transcription through chromatin by RNA polymerase II (Pol II) is accompanied by the formation of small intranucleosomal DNA loops containing the enzyme (i-loops) that are involved in survival of core histones on the DNA and arrest of Pol II during th
Externí odkaz:
https://doaj.org/article/f9dba86fed324b2b87de5486430e18a2
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 14-15 (2021)
Background: DNA accessibility in chromatin is important for proper gene expression and is regulated by multiple factors. One of them is histone chaperone FACT, which conducts large-scale ATP-independent nucleosome unfolding that increases the accessi
Externí odkaz:
https://doaj.org/article/dac69e17eed24b7093b006562edbf0ce
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 19-19 (2021)
Background: Transcription is the central point of gene regulation where the efficient maintenance of chromatin structure during the passage of RNA polymerase (Pol II) is critical for cell survival and functioning. The phosphorylation of carboxy-termi
Externí odkaz:
https://doaj.org/article/bbcf595e622a4e84aeda2e3807d73649