Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Vasilis Kola"'
Autor:
Edgar Santos, Arturo Olivares-Rivera, Sebastian Major, Renán Sánchez-Porras, Lorenz Uhlmann, Kevin Kunzmann, Roland Zerelles, Modar Kentar, Vasilis Kola, Adrian Hernández Aguilera, Mildred Gutierrez Herrera, Coline L. Lemale, Johannes Woitzik, Jed A. Hartings, Oliver W. Sakowitz, Andreas W. Unterberg, Jens P. Dreier
Publikováno v:
Critical Care, Vol 23, Iss 1, Pp 1-14 (2019)
Abstract Objective Spreading depolarizations (SD) are characterized by breakdown of transmembrane ion gradients and excitotoxicity. Experimentally, N-methyl-d-aspartate receptor (NMDAR) antagonists block a majority of SDs. In many hospitals, the NMDA
Externí odkaz:
https://doaj.org/article/9b40430ff25646b0a61030a788c3d720
Autor:
Svetlana Lublinsky, Sebastian Major, Vasilis Kola, Viktor Horst, Edgar Santos, Johannes Platz, Oliver Sakowitz, Michael Scheel, Christian Dohmen, Rudolf Graf, Hartmut Vatter, Stefan Wolf, Peter Vajkoczy, Ilan Shelef, Johannes Woitzik, Peter Martus, Jens P. Dreier, Alon Friedman
Publikováno v:
EBioMedicine, Vol 43, Iss , Pp 460-472 (2019)
Background: Disease progression and delayed neurological complications are common after aneurysmal subarachnoid hemorrhage (aSAH). We explored the potential of quantitative blood-brain barrier (BBB) imaging to predict disease progression and neurolog
Externí odkaz:
https://doaj.org/article/0e928f6c9ee2424188429bd6b7650627
Autor:
Denny Milakara, Cristian Grozea, Markus Dahlem, Sebastian Major, Maren K.L. Winkler, Janos Lückl, Michael Scheel, Vasilis Kola, Karl Schoknecht, Svetlana Lublinsky, Alon Friedman, Peter Martus, Jed A. Hartings, Johannes Woitzik, Jens P. Dreier
Publikováno v:
NeuroImage: Clinical, Vol 16, Iss , Pp 524-538 (2017)
In many cerebral grey matter structures including the neocortex, spreading depolarization (SD) is the principal mechanism of the near-complete breakdown of the transcellular ion gradients with abrupt water influx into neurons. Accordingly, SDs are ab
Externí odkaz:
https://doaj.org/article/3a13ecccfe834c32a3446ca0551db717
Autor:
Jens P. Dreier, Sebastian Major, Coline L. Lemale, Vasilis Kola, Clemens Reiffurth, Karl Schoknecht, Nils Hecht, Jed A. Hartings, Johannes Woitzik
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Spreading depolarizations (SDs) are characterized by near-complete breakdown of the transmembrane ion gradients, neuronal oedema and activity loss (=depression). The SD extreme in ischemic tissue, termed ‘terminal SD,’ shows prolonged depolarizat
Externí odkaz:
https://doaj.org/article/b488a0bf9e214b77b25ec66a5f87e0b7
Autor:
Viktor Horst, Vasilis Kola, Coline L Lemale, Sebastian Major, Maren K L Winkler, Nils Hecht, Edgar Santos, Johannes Platz, Oliver W Sakowitz, Hartmut Vatter, Christian Dohmen, Michael Scheel, Peter Vajkoczy, Jed A Hartings, Johannes Woitzik, Peter Martus, Jens P Dreier
Publikováno v:
Brain Communications. 5
In DISCHARGE-1, a recent Phase III diagnostic trial in aneurysmal subarachnoid haemorrhage patients, spreading depolarization variables were found to be an independent real-time biomarker of delayed cerebral ischaemia. We here investigated based on p
Autor:
Kevin Kunzmann, Sebastian Major, Modar Kentar, Renán Sánchez-Porras, Jed A. Hartings, Adrian Hernández Aguilera, Roland Zerelles, Edgar Santos, Lorenz Uhlmann, Mildred Gutierrez Herrera, Arturo Olivares-Rivera, Oliver W. Sakowitz, Johannes Woitzik, Vasilis Kola, Jens P. Dreier, Coline L. Lemale, Andreas Unterberg
Publikováno v:
Critical Care, Vol 23, Iss 1, Pp 1-14 (2019)
Critical Care
Critical Care
Objective Spreading depolarizations (SD) are characterized by breakdown of transmembrane ion gradients and excitotoxicity. Experimentally, N-methyl-d-aspartate receptor (NMDAR) antagonists block a majority of SDs. In many hospitals, the NMDAR antagon
Autor:
Jens P. Dreier, Maren K. L. Winkler, Sebastian Major, Viktor Horst, Svetlana Lublinsky, Vasilis Kola, Coline L. Lemale, Eun-Jeung Kang, Anna Maslarova, Irmak Salur, Janos Lückl, Johannes Platz, Devi Jorks, Ana I. Oliveira-Ferreira, Karl Schoknecht, Clemens Reiffurth, Denny Milakara, Dirk Wiesenthal, Nils Hecht, Nora F. Dengler, Agustin Liotta, Stefan Wolf, Christina M. Kowoll, André P. Schulte, Edgar Santos, Erdem Güresir, Andreas W. Unterberg, Asita Sarrafzadeh, Oliver W. Sakowitz, Hartmut Vatter, Michael Reiner, Gerrit Brinker, Christian Dohmen, Ilan Shelef, Georg Bohner, Michael Scheel, Peter Vajkoczy, Jed A. Hartings, Alon Friedman, Peter Martus, Johannes Woitzik
Publikováno v:
Brain : a journal of neurology. 145(4)
Focal brain damage after aneurysmal subarachnoid haemorrhage predominantly results from intracerebral haemorrhage, and early and delayed cerebral ischaemia. The prospective, observational, multicentre, cohort, diagnostic phase III trial, DISCHARGE-1,
Autor:
Dieter Beule, Vasilis Kola, Bentele Kajetan, Celeste Sassi, Manuel Holtgrewe, Sonja Blumenau, Ferah Yildirim, Marco Foddis, Susanne Müller
Publikováno v:
Neurobiology of aging. 104
Huntington's disease and subcortical vascular dementia display similar dementing features, shaped by different degrees of striatal atrophy, deep white matter degeneration and tau pathology. To investigate the hypothesis that Huntington's disease tran
Publikováno v:
Neuropharmacology. 134:189-207
Spreading depolarization (SD) is a phenomenon of various cerebral gray matter structures that only occurs under pathological conditions. In the present paper, we summarize the evidence from several decades of research that SD and cytotoxic edema in t
Autor:
Eun-Jeung Kang, Uldus Khojasteh, Sebastian Major, Jed A. Hartings, Johannes Woitzik, Janos Luckl, Peter Martus, Karl Schoknecht, Vasilis Kola, Ana I Oliveira-Ferreira, Maren K.L. Winkler, Viktor Horst, Coline L. Lemale, Jens P. Dreier
Publikováno v:
Brain
Experimental studies indicate that, following focal or global ischaemia, progressive recruitment of neocortical neurons into death begins when spreading depolarization gives way to a negative ultraslow potential. By monitoring patients with subarachn