Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Vasilios M. Marathias"'
Autor:
Stephen J. Mayclin, Thomas E. Edwards, Amy Sullivan, Bart L. Staker, Isabelle Q. H. Phan, Darren W. Begley, Anna Gardberg, Vasilios M. Marathias, Jan Abendroth, Peter J. Myler, Donald D. Lorimer, Daniel H. Haft, Phillip G. Pierce
Publikováno v:
Scientific Reports
During human infection, Mycobacterium tuberculosis (Mtb) survives the normally bacteriocidal phagosome of macrophages. Mtb and related species may be able to combat this harsh acidic environment which contains reactive oxygen species due to the mycob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c390665959084ea382b4f84406073d03
Autor:
Neelu Kaila, Zhao-Kui Wan, Vasilios M. Marathias, Eddine Saiah, Zahid Ali, Nikolaos Papaioannou
Publikováno v:
Tetrahedron Letters. 52:6317-6320
A convenient synthesis of 2-(2-methyl-1-(4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-3-yl)acetic acid derivatives is described using a microwave-promoted multi-step SNAr reaction. The desired products were found to exhibit atropisomerism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f36feb3c616bd1350f4316a39591038
https://doi.org/10.1016/j.tetlet.2011.08.169
https://doi.org/10.1016/j.tetlet.2011.08.169
Publikováno v:
Chirality. 22:838-843
By using a combination of inverse gated (1)H decoupled (13)C-NMR experiments1 with short acquisition times and NMR Cryo-probe technology, the sample requirements and experimental times necessary to accurately measure enantiomeric excess of small chir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292efa64b869e8721ad7165d5b6baa25
https://doi.org/10.1002/chir.20844
https://doi.org/10.1002/chir.20844
Publikováno v:
Nucleic Acids Research. 28:1969-1977
Potassium can stabilize the formation of chair- or edge-type quadruplex DNA structures and appears to be the only naturally occurring cation that can do so. As quadruplex DNAs may be important in the structure of telomere, centromere, triplet repeat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40311684935361d915bda831f9753d3f
https://doi.org/10.1093/nar/28.9.1969
https://doi.org/10.1093/nar/28.9.1969
6-Thioguanine alters the structure and stability of duplex DNA and inhibits quadruplex DNA formation
Publikováno v:
Nucleic Acids Research. 27:2860-2867
The ability to chemically synthesize biomolecules has opened up the opportunity to observe changes in structure and activity that occur upon single atom substitution. In favorable cases this can provide information about the roles of individual atoms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ad0d329fb90beb38714ef224b864f1
https://doi.org/10.1093/nar/27.14.2860
https://doi.org/10.1093/nar/27.14.2860
Publikováno v:
Biochemistry. 38:4355-4364
There are DNA sequences which adopt the same quadruplex structural type in the presence of sodium as in the presence of sodium and potassium. There are also sequences that appear to have a requirement for the presence of potassium for the adoption of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2c9f022421882896990be09433825dd
https://doi.org/10.1021/bi982604+
https://doi.org/10.1021/bi982604+
Autor:
Thy Q. Pham, Vasilios M. Marathias, Philip H. Bolton, Ke Yu Wang, Surat Kumar, S. Swaminathan
Publikováno v:
Journal of Molecular Biology. 260:378-394
The interaction of a DNA quadruplex with thrombin has been studied by first determining the sites of manganese binding to the quadruplex in the absence of thrombin. This has been followed by determining if the interactions with thrombin displace the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d8cbeb344998e20567a026994387ef
https://doi.org/10.1006/jmbi.1996.0408
https://doi.org/10.1006/jmbi.1996.0408
Publikováno v:
Journal of the American Chemical Society. 118:8207-8212
The hydrolysis of 6-aminopenicillanic acid (APA) at neutral pH, catalyzed by the class C β-lactamase of Enterobacter cloacae P99, was observed from 1H NMR spectra to yield an unexpected product, 8-hydroxypenillic acid, in bicarbonate-containing buff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c423eb942965dbc207ac3e691563fee3
https://doi.org/10.1021/ja961685z
https://doi.org/10.1021/ja961685z
Autor:
Samuel J. Danishefsky, John David Trzupek, Vasilios M. Marathias, Brendan M. Crowley, Dongjoo Lee
Publikováno v:
ChemInform. 41
The total synthesis of (V) is achieved with the construction of the intermediate (IV) with complete diastereoselectivity as a key step.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::483ada2ffb419603015d69bcaba015aa
https://doi.org/10.1002/chin.201042203
https://doi.org/10.1002/chin.201042203
Autor:
Samuel J. Danishefsky, Brendan M. Crowley, John David Trzupek, Dongjoo Lee, Vasilios M. Marathias
Publikováno v:
Journal of the American Chemical Society. 132(24)
An appropriately constructed 2-substituted derivative of L-tryptophane undergoes conversion, in a single step, to a prephalarine structure. The reaction occurs in a diastereoselective fashion, leading shortly thereafter to the naturally occurring ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abc93bc2451af5e2516636e1afa0961
https://pubmed.ncbi.nlm.nih.gov/20509657
https://pubmed.ncbi.nlm.nih.gov/20509657