Detection of KRAS Exon 2 Mutations in Circulating Tumor Cells Isolated by the ISET System from Patients with RAS Wild Type Metastatic Colorectal Cancer

Autor: Alexios Matikas, Alexandra Voutsina, Eleni Lagoudaki, Dora Hatzidaki, Maria Trypaki, Giannis Stoupis, Maria Tzardi, Dimitrios Mavroudis, Vasilios Georgoulias

Publikováno v: Translational Oncology, Vol 10, Iss 4, Pp 693-698 (2017)

INTRODUCTION: The presence of KRAS mutations in patients with metastatic colorectal cancer (mCRC) predicts poor response to agents targeting the EGFR. Even in patients with RAS wild type (WT) tumors, resistance eventually develops due to multiple mec

Externí odkaz: https://doaj.org/article/bc5bf3bebde74ec7bcaab825cdee7cf3

Chemotherapy use near the end-of-life in patients with metastatic breast cancer

Autor: Dora Hatzidaki, Jonas Bergh, Vasilios Georgoulias, Luisa Edman Kessler, Johnny Sigfridsson, Alexios Matikas, Theodoros Foukakis

Publikováno v: Breast Cancer Research and Treatment

Introduction Very few data are available regarding the use of chemotherapy in patients with metastatic breast cancer (MBC) near the end-of-life, i.e., the final month. The aim of this study was to provide a descriptive analysis of its use in two diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa14efb0e2e9c89a32ba1944860d45d
https://doi.org/10.1007/s10549-020-05663-w

Common susceptibility loci for male breast cancer

Autor: Giovanna Masala, Susan L. Neuhausen, Montserrat Garcia Closas, Vasilios Georgoulias, Paul D.P. Pharoah, Katarzyna Tomczyk, Henrik Flyger, Håkan Olsson, D. Timothy Bishop, Alison M. Dunning, Eitan Friedman, Matthew Pugh, Michael Jones, Johanna Mattson, Sarah Maguire, Richard S. Houlston, Paul A. James, Douglas F. Easton, Valentina Silvestri, Srdjan Novaković, Rosie Cooke, Maartje J. Hooning, Eleni Perraki, Manuela Gago-Dominguez, Domenico Palli, Laura Ottini, Nick Orr, Kyle Thompson, Heli Nevanlinna, Yael Laitman, Antoinette Hollestelle, Stig E. Bojesen, Timothy Winter, Alison H. Trainer, Ines Zanna, Mateja Krajc, Linda Steele, Jose E. Castelao, Emmanouil Saloustros, Olivia Fletcher, Ingrid Hedenfalk, Alan Ashworth, Anthony J. Swerdlow

Publikováno v: Maguire, S, Perrakis, E, Tomczyk, K, Jones, M, Fletcher, O, Pugh, M, Winter, T, Thompson, K, Cooke, R, Trainer, A H, Paul, J, Bojesen, S E, Flyger, H, Nevanlinna, H, Mattson, J, Friedman, E, Laitman, Y, Palli, D, Masala, G, Zanna, I, Ottini, L, Silvestri, V, Hollestelle, A, Hooning, M J, Novaković, S, Krajc, M, Gago-Dominguez, M, Castelao, J E, Olsson, H, Hedenfalk, I, Saloustros, E, Georgoulias, V, Easton, D F, Pharoah, P, Dunning, A M, Timothy Bishop, D, Neuhausen, S L, Steele, L, Ashworth, A, García-Closas, M, Houlston, R, Swerdlow, A J & Orr, N 2020, ' Common susceptibility loci for male breast cancer ', Journal of the National Cancer Institute, vol. 2020, dja101 . https://doi.org/10.1093/jnci/djaa101
Journal of the National Cancer Institute, 113(4), 453-461. Oxford University Press
JNCI Journal of the National Cancer Institute
Maguire, S, Perraki, E, Tomczyk, K, Jones, M E, Fletcher, O, Pugh, M, Winter, T, Thompson, K, Cooke, R, Trainer, A, James, P, Bojesen, S, Flyger, H, Nevanlinna, H, Mattson, J, Friedman, E, Laitman, Y, Palli, D, Masala, G, Zanna, I, Ottini, L, Silvestri, V, Hollestelle, A, Hooning, M J, Novaković, S, Krajc, M, Gago-dominguez, M, Castelao, J E, Olsson, H, Hedenfalk, I, Saloustros, E, Georgoulias, V, Easton, D F, Pharoah, P, Dunning, A M, Bishop, D T, Neuhausen, S L, Steele, L, Ashworth, A, Garcia Closas, M, Houlston, R, Swerdlow, A & Orr, N 2021, ' Common Susceptibility Loci for Male Breast Cancer ', National Cancer Institute. Journal (Online), vol. 113, no. 4, pp. 453-461 . https://doi.org/10.1093/jnci/djaa101

BackgroundThe aetiology of male breast cancer (MBC) is poorly understood. In particular, the extent to which the genetic basis of MBC differs from female breast cancer (FBC) is unknown. A previous genome-wide association study (GWAS) of MBC identifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99cf7e99c539a55981e4d31bff3d1fde
https://pure.qub.ac.uk/en/publications/549ad521-1148-4008-b767-1a9f0ecf4a66

Targeting KRAS mutated non-small cell lung cancer: A history of failures and a future of hope for a diverse entity

Autor: Alexios Matikas, Dimitrios Mistriotis, Vasilios Georgoulias, Athanasios Kotsakis

Publikováno v: Critical Reviews in Oncology/Hematology. 110:1-12

Lung cancer remains the leading cause of cancer-related deaths in both men and women. However, the discovery of several oncogenic driver mutations and the development of immune checkpoint inhibitors resulted in improved clinical outcomes for most pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413b955e86a021a30d8e0dc13e256c52
https://doi.org/10.1016/j.critrevonc.2016.12.005

Non-linear microscopy differentiates normal from pathological breast tissue

Autor: Sofia Agelaki, Savvas Bovasianos, Maria Tzardi, George Filippidis, Vasilios Georgoulias, Evangelia Gavgiotaki, Irene Athanassakis

Publikováno v: Biophotonics: Photonic Solutions for Better Health Care VI.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5789ec9e2ab0aac77be92021ac6bc61
https://doi.org/10.1117/12.2315365