Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Vasiliki Mahairaki"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 350 (2024)
Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, affect a wide variety of the population and pose significant challenges with progressive and irreversible neural cell loss. The limitations of brain-targeting therapies and the uncl
Externí odkaz:
https://doaj.org/article/7203d2cd9cca475da6517e26ca9a909c
Autor:
Ram Sagar, Cristina Zivko, Ariadni Xydia, David C. Weisman, Constantine G. Lyketsos, Vasiliki Mahairaki
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3313 (2023)
Agitation is one of the most eminent characteristics of neuropsychiatric symptoms (NPS) affecting people living with Alzheimer’s and Dementia and has serious consequences for patients and caregivers. The current consensus is that agitation results,
Externí odkaz:
https://doaj.org/article/b7132e34c7844bf5a366703f7539e940
Autor:
Tom Driedonks, Linglei Jiang, Bess Carlson, Zheng Han, Guanshu Liu, Suzanne E. Queen, Erin N. Shirk, Olesia Gololobova, Zhaohao Liao, Lyle H. Nyberg, Gabriela Lima, Liliia Paniushkina, Marta Garcia‐Contreras, Kayla Schonvisky, Natalie Castell, Mitchel Stover, Selena Guerrero‐Martin, Riley Richardson, Barbara Smith, Vasiliki Mahairaki, Charles P. Lai, Jessica M. Izzi, Eric K. Hutchinson, Kelly A. M. Pate, Kenneth W. Witwer
Publikováno v:
Journal of Extracellular Biology, Vol 1, Iss 10, Pp n/a-n/a (2022)
Abstract Extracellular vesicles (EVs) have potential in disease treatment since they can be loaded with therapeutic molecules and engineered for retention by specific tissues. However, questions remain on optimal dosing, administration and pharmacoki
Externí odkaz:
https://doaj.org/article/6033ca7d2ad846969268515852ea161c
Autor:
Ram Sagar, Ioannis Azoidis, Cristina Zivko, Ariadni Xydia, Esther S. Oh, Paul B. Rosenberg, Constantine G. Lyketsos, Vasiliki Mahairaki, Dimitrios Avramopoulos
Publikováno v:
Cells, Vol 12, Iss 15, p 1990 (2023)
The recent advances in creating pluripotent stem cells from somatic cells and differentiating them into a variety of cell types is allowing us to study them without the caveats associated with disease-related changes. We generated induced Pluripotent
Externí odkaz:
https://doaj.org/article/8a7c2e03e94344fca33a3ff8a19c8b82
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
RNA-delivery is a promising tool to develop therapies for difficult to treat diseases such as neurological disorders, by silencing pathological genes or expressing therapeutic proteins. However, in many cases RNA delivery requires a vesicle that coul
Externí odkaz:
https://doaj.org/article/933d022c048c4d1c95795ac56e722295
Autor:
Linglei Jiang, Tom A.P. Driedonks, Wouter S.P. Jong, Santosh Dhakal, H. Bart van den Berg van Saparoea, Ioannis Sitaras, Ruifeng Zhou, Christopher Caputo, Kirsten Littlefield, Maggie Lowman, Mengfei Chen, Gabriela Lima, Olesia Gololobova, Barbara Smith, Vasiliki Mahairaki, M. Riley Richardson, Kathleen R. Mulka, Andrew P. Lane, Sabra L. Klein, Andrew Pekosz, Cory Brayton, Joseph L. Mankowski, Joen Luirink, Jason S. Villano, Kenneth W. Witwer
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 3, Pp n/a-n/a (2022)
Abstract Several vaccines have been introduced to combat the coronavirus infectious disease‐2019 (COVID‐19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Current SARS‐CoV‐2 vaccines include mRNA‐conta
Externí odkaz:
https://doaj.org/article/85e40e2ab5cf4b5994d24e62d93c8c9a
Autor:
Moriah E. Katt, Lakyn N. Mayo, Shannon E. Ellis, Vasiliki Mahairaki, Jeffrey D. Rothstein, Linzhao Cheng, Peter C. Searson
Publikováno v:
Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-13 (2019)
Abstract Background Blood–brain barrier dysfunction is associated with many late-stage neurodegenerative diseases. An emerging question is whether the mutations associated with neurodegenerative diseases can independently lead to blood–brain barr
Externí odkaz:
https://doaj.org/article/fd8e31ac0ab446abab7ea24bfd20dd28
Autor:
Debamitra Das, Jiaxin Li, Senquan Liu, Esther Oh, Linzhao Cheng, Constantine Lyketsos, Vasiliki Mahairaki
Publikováno v:
Stem Cell Research, Vol 48, Iss , Pp 101979- (2020)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is the major cause of dementia in older people. Here, we report the derivation of human induced pluripotent stem cells (iPSCs) from an AD patient at age of 80 who has the APOE
Externí odkaz:
https://doaj.org/article/65359c58443d4812ae740bf93594b121
Autor:
Itzy E Morales Pantoja, Matthew D Smith, Labchan Rajbhandari, Linzhao Cheng, Yongxing Gao, Vasiliki Mahairaki, Arun Venkatesan, Peter A Calabresi, Kathryn C Fitzgerald, Katharine A Whartenby
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233980 (2020)
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS) that results in variable severities of neurodegeneration. The understanding of MS has been limited by the inaccessibility of the affected cells a
Externí odkaz:
https://doaj.org/article/575b8464d15d450992578ce877033aa5
Autor:
Yiyao Huang, Lesley Cheng, Andrey Turchinovich, Vasiliki Mahairaki, Juan C. Troncoso, Olga Pletniková, Norman J. Haughey, Laura J. Vella, Andrew F. Hill, Lei Zheng, Kenneth W. Witwer
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Extracellular vesicles (EVs) are involved in a wide range of physiological and pathological processes by shuttling material out of and between cells. Tissue EVs may thus lend insights into disease mechanisms and also betray disease when released into
Externí odkaz:
https://doaj.org/article/02d0cae4c1d8448dbb45f81a76c7ede8