Proteomics based identification of KDM5 histone demethylases associated with cardiovascular diseaseResearch in context

Autor: Marika Mokou, Julie Klein, Manousos Makridakis, Vasiliki Bitsika, Jean-Loup Bascands, Jean Sebastien Saulnier-Blache, William Mullen, Michael Sacherer, Jerome Zoidakis, Burkert Pieske, Harald Mischak, Maria G. Roubelakis, Joost P. Schanstra, Antonia Vlahou

Publikováno v: EBioMedicine, Vol 41, Iss , Pp 91-104 (2019)

Background: The increased prevalence of cardiovascular disease (CVD) indicates a demand for novel therapeutic approaches. Proteome analysis of vascular tissues from animal models and humans with CVD could lead to the identification of novel druggable

Externí odkaz: https://doaj.org/article/839a068c0692417e930ff08a97b6c677

Proteomics based identification of KDM5 histone demethylases associated with cardiovascular disease

Autor: William Mullen, Jean-Loup Bascands, Burkert Pieske, Jean Sébastien Saulnier-Blache, Julie Klein, Joost P. Schanstra, Maria G. Roubelakis, Vasiliki Bitsika, Antonia Vlahou, Marika Mokou, Jerome Zoidakis, Harald Mischak, Manousos Makridakis, Michael Sacherer

Publikováno v: EBioMedicine
EBioMedicine, Elsevier, 2019, 41, pp.91-104. ⟨10.1016/j.ebiom.2019.02.040⟩
EBioMedicine, 2019, 41, pp.91-104. ⟨10.1016/j.ebiom.2019.02.040⟩

Background The increased prevalence of cardiovascular disease (CVD) indicates a demand for novel therapeutic approaches. Proteome analysis of vascular tissues from animal models and humans with CVD could lead to the identification of novel druggable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e4b5457bb2ee13f20d7d75c41e85b2
https://www.hal.inserm.fr/inserm-03268528/document

Comparison of higher energy collisional dissociation and collision-induced dissociation MS/MS sequencing methods for identification of naturally occurring peptides in human urine

Autor: Julie Klein, George Mermelekas, Adela Ramirez-Torres, William Mullen, Vera Jankowski, Vasiliki Bitsika, Antonia Vlahou, Martin Pejchinovski, Harald Mischak

Publikováno v: PROTEOMICS - Clinical Applications. 9:531-542

The aim of this study is to determine the best fragmentation method for sequence identification of naturally occurring urinary peptides in the field of clinical proteomics.We used LC-MS/MS analysis of urine samples to determine the analytical perform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd22b069ed7067515e79a1f746904e6b
https://doi.org/10.1002/prca.201400163

Fetal Mesenchymal Stem Cells in Cancer Therapy

Autor: Maria G. Roubelakis, Vasiliki Bitsika, Antonia Vlahou

Publikováno v: Current Stem Cell Research & Therapy. 8:133-143

There is compelling evidence that mesenchymal stem cells (MSCs) can be utilized as delivery vehicles for cancer therapeutics. During the last decade, bone marrow MSCs have been used as delivery vehicles for the local production of therapeutic protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77c8caf3ba5762ec3ed1abb11d4759b
https://doi.org/10.2174/1574888x11308020004

Therapeutic potential of a distinct population of human amniotic fluid mesenchymal stem cells and their secreted molecules in mice with acute hepatic failure

Autor: Alkistis Kapelouzou, Ourania Trohatou, Nicholas P. Anagnou, Maria G. Roubelakis, Dimitra Zagoura, Kalliopi I. Pappa, Aristidis Antsaklis, Vasiliki Bitsika

Publikováno v: Gut. 61:894-906

Background There is increasing interest in the therapeutic potential of human mesenchymal stem cells (hMSCs), especially in diseases such as acute hepatic failure (AHF) that are predominantly caused by a variety of drugs and viruses. In previous stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207ce348ea6b232144b67cd449438966
https://doi.org/10.1136/gutjnl-2011-300908