Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Vasilena Gocheva"'
Autor:
Allison N Lau, Zhaoqi Li, Laura V Danai, Anna M Westermark, Alicia M Darnell, Raphael Ferreira, Vasilena Gocheva, Sharanya Sivanand, Evan C Lien, Kiera M Sapp, Jared R Mayers, Giulia Biffi, Christopher R Chin, Shawn M Davidson, David A Tuveson, Tyler Jacks, Nicholas J Matheson, Omer Yilmaz, Matthew G Vander Heiden
Publikováno v:
eLife, Vol 9 (2020)
Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between cell types within a mixed population can be challenging due to the rapid turnover of metabolit
Externí odkaz:
https://doaj.org/article/d77eaf4877714df6a00d2b9f769cb0f8
Autor:
Talya L. Dayton, Vasilena Gocheva, Kathryn M. Miller, Arjun Bhutkar, Caroline A. Lewis, Roderick T. Bronson, Matthew G. Vander Heiden, Tyler Jacks
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-9 (2018)
Abstract Background Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of the glycolytic enzyme pyruvate kinase. PKM2 expression is associated with embryogenesis, tissue regeneration, and cancer. PKM2 is also the pyruva
Externí odkaz:
https://doaj.org/article/723e6a9bab6a41d78af459afa3d7448a
Autor:
Mandar Deepak Muzumdar, Kimberly Judith Dorans, Katherine Minjee Chung, Rebecca Robbins, Tuomas Tammela, Vasilena Gocheva, Carman Man-Chung Li, Tyler Jacks
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Using mosaic analysis with double markers to label genetically-distinct clones in established tumors, the authors studied the effects of p53 loss in lung and pancreatic cancers. They find that loss of p53 enhances progression in both models but only
Externí odkaz:
https://doaj.org/article/bdfbd4f291674e74b291c197db3849ac
Autor:
Anna Prudova, Vasilena Gocheva, Ulrich auf dem Keller, Ulrich Eckhard, Oakley C. Olson, Leila Akkari, Georgina S. Butler, Nikolaus Fortelny, Philipp F. Lange, Jennifer C. Mark, Johanna A. Joyce, Christopher M. Overall
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1762-1773 (2016)
Deregulated cathepsin proteolysis occurs across numerous cancers, but in vivo substrates mediating tumorigenesis remain ill-defined. Applying 8-plex iTRAQ terminal amine isotopic labeling of substrates (TAILS), a systems-level N-terminome degradomics
Externí odkaz:
https://doaj.org/article/175b1854b1184aa8a8318d1d641e7b94
Autor:
Tyler Jacks, Jordan Bendor, Kathryn M. Miller, Robyn M. Jong, Rebecca Resnick, Arjun Bhutkar, Vasilena Gocheva, Nadya Dimitrova
Supplementary Figure S1. Targeting strategy and initial characterization of miR-143/145-deficient mice. Supplementary Figure S2. Investigating tumor suppressive functions of miR-143/145 in vitro. Supplementary Figure S3. Effect of miR-143/145 deficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86df8df39bff6f8ca0f5f89cbaa0db24
https://doi.org/10.1158/2159-8290.22530933
https://doi.org/10.1158/2159-8290.22530933
Autor:
David A. Tuveson, Nicholas J Matheson, Giulia Biffi, Evan C. Lien, Alicia M. Darnell, Laura V. Danai, Tyler Jacks, Shawn M. Davidson, Matthew G. Vander Heiden, Kiera M. Sapp, Ömer H. Yilmaz, Vasilena Gocheva, Sharanya Sivanand, Anna M. Westermark, Zhaoqi Li, Christopher R. Chin, Allison N. Lau, Raphael Ferreira, Jared R. Mayers
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Funder: Jane Coffin Childs Memorial Fund for Medical Research; FundRef: http://dx.doi.org/10.13039/100001033
Funder: Swedish Foundation for Strategic Research; FundRef: http://dx.doi.org/10.13039/501100001729
Funder: Knut and Alice Wallenbe
Funder: Swedish Foundation for Strategic Research; FundRef: http://dx.doi.org/10.13039/501100001729
Funder: Knut and Alice Wallenbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fde3c5e548d66f8a3851a8ddc356cb
Autor:
Evan C. Lien, David A. Tuveson, Zhaoqi Li, Tyler Jacks, Allison N. Lau, Raphael Ferreira, Christopher R. Chin, Giulia Biffi, Alicia M. Darnell, Jared R. Mayers, Nicholas J Matheson, Matthew G. Vander Heiden, Laura V. Danai, Sharanya Sivanand, Ömer H. Yilmaz, Kiera M. Sapp, Vasilena Gocheva, Anna M. Westermark, Shawn M. Davidson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d1959975d018296b343c25c008cf167
https://doi.org/10.7554/elife.56782.sa2
https://doi.org/10.7554/elife.56782.sa2
Autor:
Allison N. Lau, Evan C. Lien, Laura V. Danai, Kiera M. Sapp, Ömer H. Yilmaz, Vasilena Gocheva, Matthew G. Vander Heiden, Shawn M. Davidson, Raphael Ferreira, Giulia Biffi, Alicia M. Darnell, Zhaoqi Li, Nicholas J Matheson, Anna M. Westermark, Sharanya Sivanand, Christopher R. Chin, David A. Tuveson, Tyler Jacks, Jared R. Mayers
Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between various cell types within a mixed population can be limited by the rapid turnover of metabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9e0475fb71841d48fbb9cca2f5ebfd
Autor:
Elliot H. Akama-Garren, Da-Yae Lee, Vasilena Gocheva, Leah Marie Schmidt, Brittany Fitzgerald, Alice Boileve, Can Cui, Nikhil S. Joshi, Julie Cheung, Martina Damo, Gena G. Foster, Isabel Monroy, Peter Cabeceiras, Yisi Lu, Prashanth Gokare, Josephine H. Wilson, Kelli A. Connolly, Tyler Jacks, Mursal Nader, Ivana William, Greg P. Chang
Mouse models with inducible neoantigens have been historically difficult to generate because of leaky expression of antigens in the thymus, which causes central tolerance in developing CD8 and CD4 T cells. Attempts to resolve this problem using exist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8a12dd9cc0c0c518a51a2d27e37af0
https://doi.org/10.1101/2020.01.09.900894
https://doi.org/10.1101/2020.01.09.900894
Autor:
Oakley C. Olson, Ulrich Eckhard, Nikolaus Fortelny, Vasilena Gocheva, Ulrich auf dem Keller, Johanna A. Joyce, Christopher M. Overall, Philipp F. Lange, Jennifer Mark, Leila Akkari, Georgina S. Butler, Anna Prudova
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1762-1773 (2016)
Cell Reports, 16 (9)
Cell reports, vol. 16, no. 6, pp. 1762-1773
Cell Reports, 16 (9)
Cell reports, vol. 16, no. 6, pp. 1762-1773
Deregulated cathepsin proteolysis occurs across numerous cancers, but in vivo substrates mediating tumorigenesis remain ill-defined. Applying 8-plex iTRAQ terminal amine isotopic labeling of substrates (TAILS), a systems-level N-terminome degradomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77059cf238feb7365c185db2176a6527