Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Vasileios Stathias"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2538 (2024)
Deep learning is a machine learning technique to model high-level abstractions in data by utilizing a graph composed of multiple processing layers that experience various linear and non-linear transformations. This technique has been shown to perform
Externí odkaz:
https://doaj.org/article/925ab5b1d2ef41f1891e79a342fe000a
Publikováno v:
Data in Brief, Vol 49, Iss , Pp 109330- (2023)
Adenoid cystic carcinoma of the lacrimal gland (LGACC) is a slow-growing but aggressive orbital malignancy. Due to the rarity of LGACC, it is poorly understood, which makes diagnosing, treating, and monitoring disease progression difficult. The aim i
Externí odkaz:
https://doaj.org/article/67c9bede1fc247518bac2023d221e70a
Autor:
Marcin Pilarczyk, Mehdi Fazel-Najafabadi, Michal Kouril, Behrouz Shamsaei, Juozas Vasiliauskas, Wen Niu, Naim Mahi, Lixia Zhang, Nicholas A. Clark, Yan Ren, Shana White, Rashid Karim, Huan Xu, Jacek Biesiada, Mark F. Bennett, Sarah E. Davidson, John F. Reichard, Kurt Roberts, Vasileios Stathias, Amar Koleti, Dusica Vidovic, Daniel J. B. Clarke, Stephan C. Schürer, Avi Ma’ayan, Jarek Meller, Mario Medvedovic
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
There are only a few platforms that integrate multiple omics data types, bioinformatics tools, and interfaces for integrative analyses and visualization that do not require programming skills. Here the authors present an integrative web-based platfor
Externí odkaz:
https://doaj.org/article/08ffc15267ee4c3faac75343be39e39f
Autor:
Acadia H. M. Moeyersoms, Ryan A. Gallo, Michelle G. Zhang, Vasileios Stathias, Michelle M. Maeng, Dawn Owens, Rayan Abou Khzam, Yoseph Sayegh, Cynthia Maza, Sander R. Dubovy, David T. Tse, Daniel Pelaez
Publikováno v:
Cancers, Vol 15, Iss 12, p 3211 (2023)
Although primary tumors of the lacrimal gland are rare, adenoid cystic carcinoma (ACC) is the most common and lethal epithelial lacrimal gland malignancy. Traditional management of lacrimal gland adenoid cystic carcinoma (LGACC) involves the removal
Externí odkaz:
https://doaj.org/article/7df4bb4625604105ab7913324fb35592
Autor:
Clara Penas, Marie E. Maloof, Vasileios Stathias, Jun Long, Sze Kiat Tan, Jose Mier, Yin Fang, Camilo Valdes, Jezabel Rodriguez-Blanco, Cheng-Ming Chiang, David J. Robbins, Daniel J. Liebl, Jae K. Lee, Mary E. Hatten, Jennifer Clarke, Nagi G. Ayad
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The mechanisms controlling irreversible cell cycle exit in cerebellar granule progenitors (GCPs) have not been fully elucidated. Here, the authors performed RNA-sequencing of GCPs exiting the cell cycle to identify downregulation of Brd4 activity as
Externí odkaz:
https://doaj.org/article/5d102d486ad049ca91e993219a553e49
Autor:
Vasileios Stathias, Anna M. Jermakowicz, Marie E. Maloof, Michele Forlin, Winston Walters, Robert K. Suter, Michael A. Durante, Sion L. Williams, J. William Harbour, Claude-Henry Volmar, Nicholas J. Lyons, Claes Wahlestedt, Regina M. Graham, Michael E. Ivan, Ricardo J. Komotar, Jann N. Sarkaria, Aravind Subramanian, Todd R. Golub, Stephan C. Schürer, Nagi G. Ayad
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Inherent or acquired resistance to treatment of glioblastoma (GBM) is nearly universal. Here, the authors introduce a platform to identify synergistic drug combinations for patient-specific treatment of GBM based on gene expression signatures and sma
Externí odkaz:
https://doaj.org/article/27c294a5f7c843d6a3a8dc34a08977c6
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 7, Pp 100128- (2020)
Summary: The approval of the first kinase inhibitor, Gleevec, ushered in a paradigm shift for oncological treatment—the use of genomic data for targeted, efficacious therapies. Since then, over 48 additional small-molecule kinase inhibitors have be
Externí odkaz:
https://doaj.org/article/9611c9d86241428792ddeb70ba9b8b13
Autor:
Edison Ong, Jiangan Xie, Zhaohui Ni, Qingping Liu, Sirarat Sarntivijai, Yu Lin, Daniel Cooper, Raymond Terryn, Vasileios Stathias, Caty Chung, Stephan Schürer, Yongqun He
Publikováno v:
BMC Bioinformatics, Vol 18, Iss S17, Pp 43-53 (2017)
Abstract Background Aiming to understand cellular responses to different perturbations, the NIH Common Fund Library of Integrated Network-based Cellular Signatures (LINCS) program involves many institutes and laboratories working on over a thousand c
Externí odkaz:
https://doaj.org/article/0d2ffb7e1a624ac4bc3f83d3763c86a3
Autor:
Yu Lin, Saurabh Mehta, Hande Küçük-McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor I. Oprea, Stephan C. Schürer
Publikováno v:
Journal of Biomedical Semantics, Vol 8, Iss 1, Pp 1-16 (2017)
Abstract Background One of the most successful approaches to develop new small molecule therapeutics has been to start from a validated druggable protein target. However, only a small subset of potentially druggable targets has attracted significant
Externí odkaz:
https://doaj.org/article/c7f21332499a4a20a9198a03f5457353
Autor:
Lorenzo Sansalone, Eduardo A. Veliz, Nadia G. Myrthil, Vasileios Stathias, Winston Walters, Ingrid I. Torrens, Stephan C. Schürer, Steven Vanni, Roger M. Leblanc, Regina M. Graham
Publikováno v:
Cancers, Vol 11, Iss 3, p 357 (2019)
Glioblastoma (GBM) has a dismal prognosis and successful elimination of GBM stem cells (GSCs) is a high-priority as these cells are responsible for tumor regrowth following therapy and ultimately patient relapse. Natural products and their derivative
Externí odkaz:
https://doaj.org/article/e0312d8fd371450c96f08a567091009f