The Expiry of Humira® Market Exclusivity and the Entry of Adalimumab Biosimilars in Europe: An Overview of Pricing and National Policy Measures

Autor: Evelien Moorkens, Brian Godman, Isabelle Huys, Iris Hoxha, Admir Malaj, Simon Keuerleber, Silvia Stockinger, Sarah Mörtenhuber, Maria Dimitrova, Konstantin Tachkov, Luka Vončina, Vera Vlahović Palčevski, Gnosia Achniotou, Juraj Slabý, Leona Popelková, Kateřina Kohoutová, Dorthe Bartels, Ott Laius, Jaana E. Martikainen, Gisbert W. Selke, Vasileios Kourafalos, Einar Magnússon, Rannveig Einarsdóttir, Roisín Adams, Roberta Joppi, Eleonora Allocati, Arianit Jakupi, Anita Viksna, Ieva Greičiūtė-Kuprijanov, Patricia Vella Bonanno, Vincent Suttorp, Øyvind Melien, Robert Plisko, Ileana Mardare, Dmitry Meshkov, Tanja Novakovic, Jurij Fürst, Corinne Zara, Vanda Marković-Peković, Nataša Grubiša, Gustaf Befrits, Robert Puckett, Arnold G. Vulto

Publikováno v: Frontiers in Pharmacology, Vol 11 (2021)

Background: From October 2018, adalimumab biosimilars could enter the European market. However, in some countries, such as Netherlands, high discounts reported for the originator product may have influenced biosimilar entry.Objectives: The aim of thi

Externí odkaz: https://doaj.org/article/91efa0738a404ac58954a5cf23bc3c10

Barriers for Access to New Medicines: Searching for the Balance Between Rising Costs and Limited Budgets

Autor: Brian Godman, Anna Bucsics, Patricia Vella Bonanno, Wija Oortwijn, Celia C. Rothe, Alessandra Ferrario, Simone Bosselli, Andrew Hill, Antony P. Martin, Steven Simoens, Amanj Kurdi, Mohamed Gad, Jolanta Gulbinovič, Angela Timoney, Tomasz Bochenek, Ahmed Salem, Iris Hoxha, Robert Sauermann, Amos Massele, Augusto Alfonso Guerra, Guenka Petrova, Zornitsa Mitkova, Gnosia Achniotou, Ott Laius, Catherine Sermet, Gisbert Selke, Vasileios Kourafalos, John Yfantopoulos, Einar Magnusson, Roberta Joppi, Margaret Oluka, Hye-Young Kwon, Arianit Jakupi, Francis Kalemeera, Joseph O. Fadare, Oyvind Melien, Maciej Pomorski, Magdalene Wladysiuk, Vanda Marković-Peković, Ileana Mardare, Dmitry Meshkov, Tanja Novakovic, Jurij Fürst, Dominik Tomek, Corrine Zara, Eduardo Diogene, Johanna C. Meyer, Rickard Malmström, Björn Wettermark, Zinhle Matsebula, Stephen Campbell, Alan Haycox

Publikováno v: Frontiers in Public Health, Vol 6 (2018)

Introduction: There is continued unmet medical need for new medicines across countries especially for cancer, immunological diseases, and orphan diseases. However, there are growing challenges with funding new medicines at ever increasing prices alon

Externí odkaz: https://doaj.org/article/44e09c6a8ab54400ba7f5f970ab42861

Utilisation trend of long-acting insulin analogues including biosimilars across Europe: findings and implications

Autor: Mikael Hoffmann, Stuart McTaggart, Vanda Marković-Peković, Irene Langner, Skule Ingeberg, Iva Selke Krulichová, Carol Holmes, Juraj Slabý, Brian Godman, Biljana Tubić, Svens Henkuzens, Corinne Zara, Jakub Rutkowski, Jurij Fürst, András Inotai, Stephen Campbell, Konstantin Tachkov, Sean MacBride-Stewart, Ileana Mardare, Mihajlo Jakovljevic, Kristina Garuolienė, Marta Turu Pedrola, Øyvind Melien, Gisbert Selke, Magdalene Wladysiuk, Björn Wettermark, Amanj Kurdi, Arianit Jakupi, Caridad Pontes, Vasileios Kourafalos, Manfred Hinteregger, Eleonora Allocati, Radka Nejezchlebova, Guenka Petrova, Francis Kalemeera, Rita Banzi, András Harsányi, Patricia Vella Bonanno, Ott Laius, Robert Sauermann, Alice Pisana, Jolanta Gulbinovič, Anna Nachtnebel, Iris Hoxha

Publikováno v: BioMed research international, London : Hindawi Ltd., 2021, vol. 2021, art. no. 9996193, p. [1-16]
BioMed Research International
BioMed Research International, Vol 2021 (2021)

Background. Diabetes mellitus rates and associated costs continue to rise across Europe enhancing health authority focus on its management. The risk of complications is enhanced by poor glycaemic control, with long-acting insulin analogues developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f71eb049d04b088f4f63846e1ca06c
https://repository.vu.lt/VU:ELABAPDB116509835&prefLang=en_US

Synthesis, Biological Evaluation and Stability Studies of Some Novel Aza-Acridine Aminoderivatives

Autor: Nicole Pouli, Vasileios Kourafalos, Ourania E. Tsitsilonis, Maria Karelou, Athanasia Tragomalou, Panagiotis Marakos, Ioannis K. Kostakis, Evangelos Gikas

Publikováno v: Molecules
Molecules, Vol 25, Iss 4584, p 4584 (2020)
Volume 25
Issue 19

Several new amino-substituted aza-acridine derivatives bearing a basic side chain have been designed and synthesized. The antiproliferative activity of the target compounds has been evaluated against three cancer cell lines&mdash
namely HCT-116

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a8da428d6fa81ae627216ed0317a6b
https://pubmed.ncbi.nlm.nih.gov/33049986