Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Vasileia Tsintari"'
Autor:
Vasileia Tsintari, Bianca Walter, Falko Fend, Mathis Overkamp, Christian Rothermundt, Charles D. Lopez, Marcus M. Schittenhelm, Kerstin M. Kampa-Schittenhelm
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Metastatic soft tissue sarcoma (STS) are a heterogeneous group of malignancies which are not curable with chemotherapy alone. Therefore, understanding the molecular mechanisms of sarcomagenesis and therapy resistance remains a cri
Externí odkaz:
https://doaj.org/article/87ec9c1c8daa4fadaaec5ec99e1319ad
Autor:
Ingmar Rieger, Vasileia Tsintari, Mathis Overkamp, Falko Fend, Charles D. Lopez, Marcus M. Schittenhelm, Kerstin M. Kampa-Schittenhelm
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Alternative splicing is a common physiologic mechanism to generate numerous distinct gene products from one gene locus, which can result in unique gene products with differing important functional outcomes depending on cell context. Aberrant alternat
Externí odkaz:
https://doaj.org/article/cf3251de66a94a6999be4853e84a32b0
Autor:
Galatea Kallergi, Vasileia Tsintari, Stelios Sfakianakis, Ekaterini Bei, Eleni Lagoudaki, Anastasios Koutsopoulos, Nefeli Zacharopoulou, Saad Alkahtani, Saud Alarifi, Christos Stournaras, Michalis Zervakis, Vassilis Georgoulias
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-13 (2019)
Abstract Background Circulating tumor cells (CTCs) are important for metastatic dissemination of cancer. They can provide useful information, regarding biological features and tumor heterogeneity; however, their detection and characterization are dif
Externí odkaz:
https://doaj.org/article/b10336567c6e4296a1abefae5e0082b6
Autor:
Marcus Matthias Schittenhelm, Bianca Walter, Vasileia Tsintari, Birgit Federmann, Mihada Bajrami Saipi, Figen Akmut, Barbara Illing, Ulrike Mau-Holzmann, Falko Fend, Charles Darin Lopez, Kerstin Maria Kampa-Schittenhelm
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 340-351 (2019)
Background: Apoptosis-stimulating Protein of TP53-2 (ASPP2) is a tumor suppressor enhancing TP53-mediated apoptosis via binding to the TP53 core domain. TP53 mutations found in cancers disrupt ASPP2 binding, arguing for an important role of ASPP2 in
Externí odkaz:
https://doaj.org/article/162a0dcf7af743ecb55394431c13be11
Autor:
Vasileia Tsintari, Bianca Walter, Falko Fend, Mathis Overkamp, Christian Rothermundt, Charles D. Lopez, Marcus M. Schittenhelm, Kerstin M. Kampa-Schittenhelm
Publikováno v:
BMC cancer. 22(1)
Background Metastatic soft tissue sarcoma (STS) are a heterogeneous group of malignancies which are not curable with chemotherapy alone. Therefore, understanding the molecular mechanisms of sarcomagenesis and therapy resistance remains a critical cli
Autor:
Bianca Walter, Marcus M Schittenhelm, Kerstin M Kampa-Schittenhelm, Falko Fend, Mihada Bajrami Saipi, Birgit Federmann, Vasileia Tsintari, Charles D. Lopez, Ulrike A. Mau-Holzmann, Figen Akmut, Barbara Illing
Publikováno v:
EBioMedicine. 42:340-351
Background Apoptosis-stimulating Protein of TP53-2 (ASPP2) is a tumor suppressor enhancing TP53-mediated apoptosis via binding to the TP53 core domain. TP53 mutations found in cancers disrupt ASPP2 binding, arguing for an important role of ASPP2 in T
Autor:
Rebecca Fröhlich, Kerstin Maria Kampa-Schittenhelm, Vasileia Tsintari, Marcus M. Schittenhelm
Publikováno v:
Blood. 138:3343-3343
In recent years, it has become increasingly apparent that BCL-2 inhibition in AML is a clinically highly effective approach - and the first BCL-2 inhibitor, venetoclax, has gained FDA and EMA approval. However, drug resistance frequently occurs and m
Autor:
Balazs Gyorffy, Max Kaiser, Kerstin Maria Kampa-Schittenhelm, Gunnar Blumenstock, Marcus M. Schittenhelm, Vasileia Tsintari
Publikováno v:
Blood. 138:1298-1298
ASPP1 (PPP1R13B) belongs to a family of p53-binding proteins and enhances apoptosis by stimulation of p53-transactivation of selected proapoptotic target genes. It is preferentially expressed in hematopoietic stem cells (HSC) and together with p53 pr
Autor:
Vassilis Georgoulias, Nefeli Zacharopoulou, Saad Alkahtani, Stelios Sfakianakis, Ekaterini Bei, Christos Stournaras, Galatea Kallergi, Vasileia Tsintari, Michalis Zervakis, Eleni Lagoudaki, Anastasios Koutsopoulos, Saud Alarifi
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-13 (2019)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Background Circulating tumor cells (CTCs) are important for metastatic dissemination of cancer. They can provide useful information, regarding biological features and tumor heterogeneity; however, their detection and characterization are difficult du
Autor:
E. Schleicher, I. Bonzheim, S.T. Dreher, T. Ganief, Marcus M. Schittenhelm, L. Haeusser, M. Bonin, T. Haverkamp, W. Vogel, Barbara Illing, H.J. Bühring, Gunnar Blumenstock, Figen Akmut, Kerstin M Kampa-Schittenhelm, Vasileia Tsintari, Ulrike A. Mau-Holzmann
Publikováno v:
EBioMedicine
EBioMedicine, Vol 54, Iss, Pp-(2020)
EBioMedicine, Vol 54, Iss, Pp-(2020)
Background: Overriding the differentiation blockage in acute myeloid leukemia (AML) is the most successful mode-of-action in leukemia therapy – now curing the vast majority of patients with acute promyelocytic leukemia (APL) using all-trans retinoi