Review: The use of functional magnetic resonance imaging (fMRI) in clinical trials and experimental research studies for depression

Autor: Vasileia Kotoula, Jennifer W. Evans, Claire E. Punturieri, Carlos A. Zarate

Publikováno v: Frontiers in Neuroimaging, Vol 2 (2023)

Functional magnetic resonance imaging (fMRI) is a non-invasive technique that can be used to examine neural responses with and without the use of a functional task. Indeed, fMRI has been used in clinical trials and pharmacological research studies. I

Externí odkaz: https://doaj.org/article/61f840078a8c442eb8e0540cf01cf6cd

Strategic decision making and prediction differences in autism

Autor: Vasileios Mantas, Artemios Pehlivanidis, Katerina Papanikolaou, Vasileia Kotoula, Charalambos Papageorgiou

Publikováno v: PeerJ, Vol 10, p e13328 (2022)

Background Several theories in autism posit that common aspects of the autism phenotype may be manifestations of an underlying differentiation in predictive abilities. The present study investigates this hypothesis in the context of strategic decisio

Externí odkaz: https://doaj.org/article/d36936cd2aee42449fd69ddefcb36d36

Reduced cortical cerebral blood flow in antipsychotic-free first-episode psychosis and relationship to treatment response

Autor: Pierluigi Selvaggi, Sameer Jauhar, Vasileia Kotoula, Fiona Pepper, Mattia Veronese, Barbara Santangelo, Fernando Zelaya, Federico E. Turkheimer, Mitul A. Mehta, Oliver D. Howes

Publikováno v: Psychological Medicine. :1-11

Background Altered cerebral blood flow (CBF) has been found in people at risk for psychosis, with first-episode psychosis (FEP) and with chronic schizophrenia (SCZ). Studies using arterial spin labelling (ASL) have shown reduction of cortical CBF and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44da442a97e45f20f19ebe54313ee36
https://doi.org/10.1017/s0033291722002288

Ketamine Modulates the Neural Correlates of Reward Processing in Unmedicated Patients in Remission From Depression

Autor: Maura L. Furey, H. Valerie Curran, Nuria K Mackes, Mitul A. Mehta, Peter C.T. Hawkins, Vasileia Kotoula, Argyris Stringaris, Ndabezinhle Mazibuko

Publikováno v: Kotoula, V, Stringaris, A, Mackes, N, Mazibuko, N, Hawkins, P C T, Furey, M, Curran, H V & Mehta, M A 2022, ' Ketamine Modulates the Neural Correlates of Reward Processing in Unmedicated Patients in Remission From Depression ', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 7, no. 3, pp. 285-292 . https://doi.org/10.1016/j.bpsc.2021.05.009

Background Ketamine as an antidepressant improves anhedonia as early as 2 hours after infusion. These drug effects are thought to be exerted via actions on reward-related brain areas—yet these actions remain largely unknown. Our study investigates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd0ce917c034de799fd59c942d9743f
https://kclpure.kcl.ac.uk/en/publications/11f01dfa-8aa4-49d3-905b-7d832b80dfae

The relationship between grey matter volume and striatal dopamine function in psychosis: a multi-modal 18F-DOPA PET and voxel-based morphometry study

Autor: Seoyoung Kim, Sameer Jauhar, Oliver D. Howes, Fiona Pepper, Federico Turkheimer, Mattia Veronese, Enrico D'Ambrosio, Euitae Kim, Maria Rogdaki, Matthew J. Kempton, Jun Soo Kwon, Vasileia Kotoula, Ilaria Bonoldi

Publikováno v: Molecular psychiatry
D'Ambrosio, E, Jauhar, S, Kim, S, Veronese, M, Rogdaki, M, Pepper, F, Bonoldi, I, Kotoula, V, Kempton, M J, Turkheimer, F, Kwon, J S, Kim, E & Howes, O D 2021, ' The relationship between grey matter volume and striatal dopamine function in psychosis : a multimodal 18F-DOPA PET and voxel-based morphometry study ', Molecular Psychiatry, vol. 26, no. 4, pp. 1332–1345 . https://doi.org/10.1038/s41380-019-0570-6

A leading hypothesis for schizophrenia and related psychotic disorders proposes that cortical brain disruption leads to subcortical dopaminergic dysfunction, which underlies psychosis in the majority of patients who respond to treatment. Although sup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f421216d634cccbb9280fe4e986f57
http://europepmc.org/articles/PMC7610423