Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Vasile I. Pavlov"'
Autor:
Julian K. Horwitz, Sofia Bin, Robert L. Fairchild, Karen S. Keslar, Zhengzi Yi, Weijia Zhang, Vasile I. Pavlov, Yansui Li, Joren C. Madsen, Paolo Cravedi, Peter S. Heeger
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Erythropoietin (EPO) has multiple nonerythropoietic functions, including immune modulation, but EPO’s effects in transplantation remain incompletely understood. We tested the mechanisms linking EPO administration to prolongation of murine heterotop
Externí odkaz:
https://doaj.org/article/1b0271f84e3245dda23663c661913691
Autor:
Nicholas Chun, Rosalind L. Ang, Mark Chan, Robert L. Fairchild, William M. Baldwin III, Julian K. Horwitz, Jesse D. Gelles, Jerry Edward Chipuk, Michelle A. Kelliher, Vasile I. Pavlov, Yansui Li, Dirk Homann, Peter S. Heeger, Adrian T. Ting
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
TNF ligation of TNF receptor 1 (TNFR1) promotes either inflammation and cell survival by (a) inhibiting RIPK1’s death-signaling function and activating NF-κB or (b) causing RIPK1 to associate with the death-inducing signaling complex to initiate a
Externí odkaz:
https://doaj.org/article/1cef15809b5044ec872dc4819293a566
Autor:
Brittany A. Potz, Laura A. Scrimgeour, Vasile I. Pavlov, Neel R. Sodha, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 12 (2018)
Background Mesenchymal stem cell–derived extracellular vesicles (EVs) are believed to be cardioprotective in myocardial infarct. The objective of this study was to examine the effects of human mesenchymal cell–derived EV injection on cardiac func
Externí odkaz:
https://doaj.org/article/68202c77a0c8435e85e899fbb43cf64f
Autor:
Vasile I Pavlov, Rosalind L. Ang, Adrian T. Ting, Yansui Li, Michelle A. Kelliher, Dirk Homann, Julian K. Horwitz, Nicholas Chun, William M. Baldwin, Robert L. Fairchild, Peter S. Heeger, Jesse D. Gelles, Mark Chan, Jerry E. Chipuk
Publikováno v:
JCI Insight
Tumor necrosis factor (TNF) ligation of TNF receptor 1 (TNFR1) promotes either inflammation and cell survival by inhibiting RIPK1's death-signaling function and activating NF-kB, or causes RIPK1 to associate with the death-inducing signaling complex
Autor:
Zhiqi Zhang, Vasile I Pavlov, Isabella Lawandy, Reed Jaworski, Yuhong Liu, Guangbin Shi, Frank W. Sellke, Jun Feng, Laura A. Scrimgeour
Publikováno v:
Molecular and Cellular Biochemistry
Metabolic syndrome (MetS) is associated with alterations in coronary vascular smooth muscle and endothelial function. The current study examined the contractile response of the isolated coronary arterioles to serotonin in pigs with and without MetS a
Autor:
Jun Feng, Ahmad Aboulgheit, Zhiqi Zhang, Neel R. Sodha, Martin Kolodziejczak, Frank W. Sellke, Vasile I Pavlov, Richard T. Clements
Publikováno v:
Circulation Research. 125
Background: Inactivation of small-conductance calcium-activated potassium (SK) channels contributes to coronary microvascular dysfunction in patients after cardioplegic arrest, cardiopulmonary bypass (CP/CPB) and cardiac surgery. SK-channel activatio
Autor:
Michael Sturek, Se Young Yoon, Maryam Karimi, Olivia Ziegler, Vahid Agbortoko, Jun Feng, Stoiana Alexandrova, Frank W. Sellke, Boian S. Alexandrov, Anny Usheva, Nivedita Sriram, Vasile I Pavlov, John M. Asara
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0225857 (2019)
PLoS ONE, Vol 14, Iss 12, p e0225857 (2019)
Although the high-fat-diet-induced metabolic syndrome (MetS) is a precursor of human cardiac pathology, the myocardial metabolic state in MetS is far from clear. The discrepancies in metabolite handling between human and small animal models and the d
Autor:
Masayuki Ozaki, Rafail I. Kushak, Vasile I. Pavlov, Ying S. Tan, Yulin Kang, Mikkel-Ole Skjoedt, Yasuhiko Taira, Bohan Liu, Eric F. Grabowski, Daniel C. Boyle, Gregory L. Stahl
Publikováno v:
Kidney International. 90:774-782
Hemolytic uremic syndrome caused by Shiga toxin–producing Escherichia coli (STEC HUS) is a worldwide endemic problem, and its pathophysiology is not fully elucidated. Here we tested whether the mannose-binding lectin (MBL2), an initiating factor of
Autor:
Laura A. Scrimgeour, M. Ruhul Abid, Neel R. Sodha, Vasile I Pavlov, Brittany A. Potz, Frank W. Sellke
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Mesenchymal stem cell–derived extracellular vesicles ( EV s) are believed to be cardioprotective in myocardial infarct. The objective of this study was to examine the effects of human mesenchymal cell–derived EV injection on cardiac fu
Autor:
Ying S. Tan, Vasile I. Pavlov, William B. Gorsuch, Erin E. McClure, Chenhui Zou, Laura R. La Bonte, Gregory L. Stahl
Publikováno v:
The American Journal of Pathology. 185:347-355
Myocardial infarction and coagulation disorders are leading causes of disability and death in the world. An important role of the lectin complement pathway in myocardial infarction and coagulation has been demonstrated in mice genetically deficient i