Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives

Autor: Ionuţ Ledeţi, Ştefana Avram, Vasile Bercean, Gabriela Vlase, Titus Vlase, Adriana Ledeţi, Istvan Zupko, Marius Mioc, Lenuţa-Maria Şuta, Codruţa Şoica, Cristina Dehelean

Publikováno v: Molecules, Vol 20, Iss 12, Pp 22691-22702 (2015)

Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several

Externí odkaz: https://doaj.org/article/f4d698d484ff4c7a977808e9af99b24f

Preparation and Antibacterial Properties of Substituted 1,2,4-Triazoles

Autor: Ionuţ Ledeţi, Vasile Bercean, Anda Alexa, Codruţa Şoica, Lenuţa-Maria Şuta, Cristina Dehelean, Cristina Trandafirescu, Delia Muntean, Monica Licker, Adriana Fuliaş

Publikováno v: Journal of Chemistry, Vol 2015 (2015)

Background. Both 1,2,3- and 1,2,4-triazoles are nowadays incorporated in numerous antibacterial pharmaceutical formulations. Aim. Our study aimed to prepare three substituted 1,2,4-triazoles and to evaluate their antibacterial properties. Materials a

Externí odkaz: https://doaj.org/article/0523ccf2875f4604968d7f8986f27f13

Design, synthesis and pharmaco-toxicological assessment of 5-mercapto-1,2,4-triazole derivatives with antibacterial and antiproliferative activity

Autor: Florina Andrica, Cristina Dehelean, Roxana Ghiulai, Ludovic Kurunczi, Delia Muntean, Codruta Soica, Aristides M. Tsatsakis, Marius Mioc, Sorin Avram, Mihaela Balan Porcarasu, Demetrios A. Spandidos, Dorina Coricovac, Vasile Bercean

Publikováno v: International Journal of Oncology

The extensive biochemical research of multiple types of cancer has revealed important enzymatic signaling pathways responsible for tumor occurrence and progression, thus compelling the need for the discovery of new means with which to block these sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c331dc341f0fd79d69e0e8dc39b73bd
http://europepmc.org/articles/PMC5363884

Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives

Autor: Stefana Avram, Titus Vlase, Adriana Ledeţi, István Zupkó, Marius Mioc, Vasile Bercean, Codruţa Şoica, Lenuţa Maria Şuta, Ionuţ Ledeţi, Cristina Dehelean, Gabriela Vlase

Publikováno v: Molecules, Vol 20, Iss 12, Pp 22691-22702 (2015)
Molecules
Volume 20
Issue 12
Pages 22691-22702
Molecules; Volume 20; Issue 12; Pages: 22691-22702

Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bb8f664fa739eff212058042583b60
http://www.mdpi.com/1420-3049/20/12/19876

Kinetic of solid-state degradation of transitional coordinative compounds containing functionalized 1,2,4-triazolic ligand

Autor: Ionuţ Ledeţi, Vasile Bercean, Adriana Fuliaş, Titus Vlase, Gabriela Vlase

Publikováno v: Journal of Thermal Analysis and Calorimetry. 121:1049-1057

Three coordinative compounds containing Ni(II), Cd(II) and Zn(II) and functionalized 1,2,4-triazolic ligand were prepared and characterized by both thermal and non-thermal methods. The applied instrumental techniques consisted in TG/DTG/HF analysis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::491a1f371a92c6143199f0efbe80138c
https://doi.org/10.1007/s10973-015-4520-5