Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Vasil H. Vasilev"'
Publikováno v:
Journal of the American Chemical Society. 144:16332-16337
From both structural and functional perspectives, the large family of daphnane diterpene orthoesters (DDOs) represent a truly remarkable class of natural products. As potent lead compounds for the treatment of pain, neurodegeneration, HIV/AIDS, and c
Publikováno v:
Tetrahedron. 75:4212-4221
Synthetic studies toward the daphnane and tigliane diterpenes, a large family of natural products from the plant families Euphorbiaceae and Thymelaeaceae, are reported. Retrosynthetic analysis traced these molecules back to an aromatic precursor and
Publikováno v:
Journal of the American Chemical Society. 139:13562-13569
Herein we report that under mild solvolytic conditions, enantioenriched bromochlorides can be ionized, stereospecifically cyclized to an array of complex bromocyclic scaffolds, or intermolecularly trapped by exogenous nucleophiles. Mechanistic invest
Publikováno v:
Angewandte Chemie International Edition. 55:11476-11479
The brominated chamigrene sesquiterpenes constitute a large subclass of bromocyclohexane-containing natural products, yet no general enantioselective strategy for the synthesis of these small molecules exists. Herein we report a general strategy for