An approach for the identification of targets specific to bone metastasis using cancer genes interactome and gene ontology analysis

Autor: Vashisht, Shikha, Bagler, Ganesh

Metastasis is one of the most enigmatic aspects of cancer pathogenesis and is a major cause of cancer-associated mortality. Secondary bone cancer (SBC) is a complex disease caused by metastasis of tumor cells from their primary site and is characteri

Externí odkaz: http://arxiv.org/abs/1112.1510

Key role of SMN/SYNCRIP and RNA-Motif 7 in spinal muscular atrophy: RNA-Seq and motif analysis of human motor neurons

Autor: Rizzo, Federica, Nizzardo, Monica, Vashisht, Shikha, Molteni, Erika, Melzi, Valentina, Taiana, Michela, Salani, Sabrina, Santonicola, Pamela, Di Schiavi, Elia, Bucchia, Monica, Bordoni, Andreina, Faravelli, Irene, Bresolin, Nereo, Comi, Giacomo Pietro, Pozzoli, Uberto, Corti, Stefania

Publikováno v: Brain
Brain (Online) 142 (2019): 276–294. doi:10.1093/brain/awy330
info:cnr-pdr/source/autori:Rizzo, Federica; Nizzardo, Monica; Vashisht, Shikha; Molteni, Erika; Melzi, Valentina; Taiana, Michela; Salani, Sabrina; Santonicola, Pamela; Di Schiavi, Elia; Bucchia, Monica; Bordoni, Andreina; Faravelli, Irene; Bresolin, Nereo; Bresolin, Nereo; Comi, Giacomo Pietro; Comi, Giacomo Pietro; Pozzoli, Uberto; Corti, Stefania; Corti, Stefania/titolo:Key role of SMN%2FSYNCRIP and RNA-Motif 7 in spinal muscular atrophy: RNA-Seq and motif analysis of human motor neurons/doi:10.1093%2Fbrain%2Fawy330/rivista:Brain (Online)/anno:2019/pagina_da:276/pagina_a:294/intervallo_pagine:276–294/volume:142

The molecular mechanisms responsible for selective motor neuron loss in SMA remain elusive. Rizzo et al. show that deregulated transcripts in SMA-motor neurons share motif 7, targeted by SYNCRIP, which binds SMN. Impaired SYNCRIP-SMN interaction lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfe322502031e97bdf1fd54a24972a7
https://doi.org/10.1093/brain/awy330

Additional file 4 of Transcriptome profile of the sinoatrial ring reveals conserved and novel genetic programs of the zebrafish pacemaker

Autor: Minhas, Rashid, Loeffler-Wirth, Henry, Siddiqui, Yusra H., Obrębski, Tomasz, Vashisht, Shikha, Nahia, Karim Abu, Paterek, Alexandra, Brzozowska, Angelika, Bugajski, Lukasz, Piwocka, Katarzyna, Korzh, Vladimir, Binder, Hans, Winata, Cecilia Lanny

Additional file 4: Figure S4. Analysis of morpholino specificity. Specificity of MO against Pard6a, Prom2, and Atp1a1a.2 was assayed by co-injection with p53 MO and rescue experiment. Comparison between those injected with only 4 ng of gene-specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48aff062b248b8953111056dc81e4908

Additional file 1 of Transcriptome profile of the sinoatrial ring reveals conserved and novel genetic programs of the zebrafish pacemaker

Autor: Minhas, Rashid, Loeffler-Wirth, Henry, Siddiqui, Yusra H., Obrębski, Tomasz, Vashisht, Shikha, Nahia, Karim Abu, Paterek, Alexandra, Brzozowska, Angelika, Bugajski, Lukasz, Piwocka, Katarzyna, Korzh, Vladimir, Binder, Hans, Winata, Cecilia Lanny

Additional file 1: Figure S1. FACS sorting and qPCR validation of GFP positive and GFP negative samples. (A) FACS sorting of the embryonic hearts at 72hpf shows distinct GFP positive and GFP negative cell populations. (B) qPCR validation of the sampl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ac797cbf25632c779f64e3cf8ddd08

COMPUTATIONAL APPROACHES IN THE ESTIMATION AND ANALYSIS OF TRANSCRIPTS DIFFERENTIAL EXPRESSION AND SPLICING: APPLICATION TO SPINAL MUSCULAR ATROPHY

Autor: VASHISHT, SHIKHA

Spinal Muscular Atrophy (SMA) is among the most common genetic neurological diseases that cause infant mortality. SMA is caused by deletion or mutations in the survival motor neuron 1 gene (SMN1), which are expected to generate alterations in RNA tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f867b4bb3d1076c0c1fb1ae33271a2a0