Výsledky vyhledávání - "Vascular smooth muscle cell differentiation"

Akademický článek

Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis

Autor: Siyuan Cheng, Ivan Fan Xia, Renate Wanner, Javier Abello, Amber N Stratman, Stefania Nicoli

Publikováno v: eLife, Vol 13 (2024)

Vascular smooth muscle cells (VSMCs) envelop vertebrate brain arteries and play a crucial role in regulating cerebral blood flow and neurovascular coupling. The dedifferentiation of VSMCs is implicated in cerebrovascular disease and neurodegeneration

Externí odkaz: https://doaj.org/article/bcca6ef413674024822362f554fd1b5d

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Akademický článek

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Generation of niche tuned antifibrotic fibroblasts and non‐viral mediated endothelial commitment using adipose stem cells for dermal graft development

Autor: Rashmi Ramakrishnan, Amita Ajit, Santhoshkumar Thankayyan Retnabai, Lissy K. Krishnan, Manesh Senan

Publikováno v: Journal of Biomedical Materials Research Part B: Applied Biomaterials. 108:2807-2819

Cell-based skin substitute generation has seen considerable development. Combining synthetic scaffolds with biomimetic fibrin does direct both exogenous and endogenous stem cell differentiation, addressing needs for reliable tissue engineering. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132728ceb15d82026cf4757d42bc5a72
https://doi.org/10.1002/jbm.b.34611

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A Loss of Nuclear—Cytoskeletal Interactions in Vascular Smooth Muscle Cell Differentiation Induced by a Micro-Grooved Collagen Substrate Enabling the Modeling of an In Vivo Cell Arrangement

Autor: Kazuaki Nagayama

Publikováno v: Bioengineering, Vol 8, Iss 124, p 124 (2021)
Bioengineering
Volume 8
Issue 9

Vascular smooth muscle cells (VSMCs) remodel vascular walls actively owing to mechanical cues and dedifferentiate to the synthetic phenotype from contractile phenotype in pathological conditions. It is crucial to clarify the mechanisms behind the VSM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fbd5382dd8085343eb5d787250f730
https://www.mdpi.com/2306-5354/8/9/124

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Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy

Autor: Hye Sun Gwak, Jee Eun Chung, Woorim Kim, Kyung Eun Lee, Byung Chul Chang, Jeong Yee

Publikováno v: Drug Design, Development and Therapy. 13:1717-1727

Purpose: GATA4 and GATA6 are known to have potential roles in vascular regulation by affecting vascular smooth muscle cell differentiation and atrial natriuretic peptide levels. The aim of this retrospective study was to investigate the associations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::158374fc9aa9fbb68723643d2a29017b
https://doi.org/10.2147/dddt.s198018

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Biomechanical analysis of the mechanical environment of the cell nucleus in serum starvation-induced vascular smooth muscle cell differentiation

Autor: Kazuaki Nagayama

Publikováno v: Journal of Biomechanical Science and Engineering. 14:19-00364

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37e8927e142fa6bedcacb5a6e69ac966
https://doi.org/10.1299/jbse.19-00364

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TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia

Autor: Roshni Srivastava, Adebowale J. Adeniran, Jiasheng Zhang, Fatemehsadat Esteghamat, Arya Mani, Harshvardhan Rolyan, Marcelo A. Nobrega, Neha Bhat, Arnar Geirsson, Guanghao Ge, Lingjuan Hong, Na Li, Kathleen A. Martin, Yi Xie

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology

Supplemental Digital Content is available in the text.
Objective— TCF7L2 (transcription factor 7-like 2) is a Wnt-regulated transcription factor that maintains stemness and promotes proliferation in embryonic tissues and adult stem cells. Mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7c8a29884819bbeeaa0550fc0e9fa3
http://europepmc.org/articles/PMC6365015

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rBMSCs/ITGA5B1 Promotes Human Vascular Smooth Muscle Cell Differentiation via Enhancing Nitric Oxide Production

Autor: Cong Xu, Jie Ding, Ying-xin Zhang, Peng Xia, Haiying Chen, Shengjun Ma, Hongli Yang

Publikováno v: International Journal of Stem Cells

Background and objectives Previous studies have shown that integrins alpha5beta1 (ITGA5B1) gene-modified rat bone marrow mesenchymal stem cells (rBMSCs) could prevent cell anoikis and increase the nitric oxide (NO) production. Here we examined the ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7624cbb2972ad1c2853312f95bdb18
https://doi.org/10.15283/ijsc18079

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Purine-rich element binding protein B attenuates the coactivator function of myocardin by a novel molecular mechanism of smooth muscle gene repression

Autor: Robert J. Kelm, Andrea T. Foote, Shu-Xia Wang, Lauren A. Ferris

Publikováno v: Molecular and Cellular Biochemistry.

Myocardin is a potent transcriptional coactivator protein, which functions as the master regulator of vascular smooth muscle cell differentiation. The cofactor activity of myocardin is mediated by its physical interaction with serum response factor,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f3fa0a4c90b39f9bd09e2078ad39e35
https://doi.org/10.1007/s11010-021-04117-1

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High NOR-1 (Neuron-Derived Orphan Receptor 1) Expression Strengthens the Vascular Wall Response to Angiotensin II Leading to Aneurysm Formation in Mice

Autor: Ana M. Briones, Carme Ballester-Servera, Laia Cañes, Cristina Rodríguez, José Martínez-González, J. A. Alonso, Ingrid Martí-Pàmies, Elena Contreras Serrano

Publikováno v: HYPERTENSION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Digital.CSIC. Repositorio Institucional del CSIC

No drug therapy has shown to limit abdominal aortic aneurysm (AAA) growth or rupture, and the understanding of the disease biology is incomplete; whereby, one challenge of vascular medicine is the development of good animal models and therapies for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c86ddc3c9c41304571fdbef4645b4e0
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5028

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