Nanobodies As Novel Agents for Targeting Angiogenesis in Solid Cancers

Autor: Roghaye Arezumand, Abbas Alibakhshi, Javad Ranjbari, Ali Ramazani, Serge Muyldermans

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Solid cancers are dependent on angiogenesis for sustenance. The FDA approval of Bevacizumab in 2004 inspired many scientists to develop more inhibitors of angiogenesis. Although several monoclonal antibodies (mAbs) are being administered to successfu

Externí odkaz: https://doaj.org/article/af233850aeca42c08055051671cabc3c

Therapeutic Strategies for Corneal Wound Angiogenesis

Autor: Sumana R Chintalapudi

Publikováno v: Current Pathobiology Reports. 8:15-24

Corneal diseases are a major cause of blindness worldwide, resulting from corneal scarring and neovascularization. There is an unmet need for developing effective therapies to prevent and/or treat corneal neovascularization. Topical steroid medicatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f2d51405392de5d95c563d7107a734b
https://doi.org/10.1007/s40139-020-00206-w

Genetics of PlGF plasma levels highlights a role of its receptors and supports the link between angiogenesis and immunity

Autor: Marina Ciullo, Céline Bellenguez, Teresa Nutile, Daniela Ruggiero, Alfonsina Tirozzi, Anne-Louise Leutenegger, Stefania Nappo

Publikováno v: Scientific reports (Nature Publishing Group) 11 (2021). doi:10.1038/s41598-021-96256-0
info:cnr-pdr/source/autori:Ruggiero D.; Nutile T.; Nappo S.; Tirozzi A.; Bellenguez C.; Leutenegger A.-L.; Ciullo M./titolo:Genetics of PlGF plasma levels highlights a role of its receptors and supports the link between angiogenesis and immunity/doi:10.1038%2Fs41598-021-96256-0/rivista:Scientific reports (Nature Publishing Group)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:11
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Placental growth factor (PlGF) is a member of the vascular endothelial growth factor family and is involved in bone marrow-derived cell activation, endothelial stimulation and pathological angiogenesis. High levels of PlGF have been observed in sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199683e626511359903d3b5da984f98c
https://doi.org/10.1038/s41598-021-96256-0

Placental growth factor gene silencing mitigates the epithelial-to-mesenchymal transition via the p38 MAPK pathway in rats with hyperoxia-induced lung injury

Autor: Liang Zhang, Shuang Zhao, Hongmin Wu, Gang Luo

Publikováno v: Molecular Medicine Reports

Hyperoxia may cause pulmonary fibrosis in neonates and is characterized by the epithelial‑to‑mesenchymal transition (EMT) of alveolar epithelial cells. The placental growth factor (PLGF) gene is a member of the vascular endothelial growth factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfb1f6051aeaa46cb2f98f5ec31f380
http://europepmc.org/articles/PMC6854522

Targeting Angiogenesis in Colorectal Carcinoma

Autor: Kazuto Harada, Anthony Lopez, Jaffer A. Ajani, Maria Vasilakopoulou, Namita Shanbhag

Publikováno v: Drugs. 79:63-74

Neo-angiogenesis plays a key role in colorectal cancer, with the vascular endothelial growth factor family proteins and their receptors in particular triggering multiple signaling networks that result in endothelial cell survival, migration, mitogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77dfa030db723c06353cf80b5466cb02
https://doi.org/10.1007/s40265-018-1037-9