Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers

Autor: David Mordasini, Anne Labarre, Carlos J. Alcaide-Corral, Laurent A. Decosterd, Chrismita Hegde, Ellen Neven, Mark G. MacAskill, Marc Maillard, Dany Spaggiari, Michel Burnier, David E. Newby, Geert J. Behets, Bastien Castagner, Mattias E. Ivarsson, Patrick C. D'Haese, Antonia E. Schantl, Victoria C. Beindl, Adriana Tavares, Roberto Maj, Anja Verhulst, Jean-Christophe Leroux, Olivier Phan

Publikováno v: Schantl, A E, Verhulst, A, Neven, E, Behets, G J, D'Haese, P C, Maillard, M, Mordasini, D, Phan, O, Burnier, M, Spaggiari, D, Decosterd, L A, MacAskill, M G, Alcaide-Corral, C J, Tavares, A A S, Newby, D E, Beindl, V C, Maj, R, Labarre, A, Hedge, C, Castagner, B, Ivarsson, M E & Leroux, J-C 2020, ' Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers ', Nature Communications, vol. 11, 721 . https://doi.org/10.1038/s41467-019-14091-4
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature communications, vol. 11, no. 1, pp. 721
Nature communications
Nature Communications, 11 (1)

Myo-inositol hexakisphosphate (IP6) is a natural product known to inhibit vascular calcification (VC), but with limited potency and low plasma exposure following bolus administration. Here we report the design of a series of inositol phosphate analog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb9a8129d650ca324178fbd915550a3
https://www.pure.ed.ac.uk/ws/files/134711722/s41467_019_14091_4.pdf

A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions

Autor: Carlijn V. C. Bouten, Cecilia Sahlgren, Andreas Pollet, Jaap M.J. den Toonder, Oscar M. J. A. Stassen, Nicole C. A. van Engeland

Publikováno v: Lab on a Chip
Lab on a Chip, 18(11), 1607-1620. Royal Society of Chemistry

Cell signalling and mechanics influence vascular pathophysiology and there is an increasing demand for in vitro model systems that enable examination of signalling between vascular cells under hemodynamic conditions. Current 3D vessel wall constructs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236c99d6b3dd93808cde83b21cf4b25d

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression

Autor: Carolina Roselli, Renate B. Schnabel, Valerio Bianchi, Aditi Trehan, Joseph E. Hadaya, Derek Klarin, Wouter de Laat, Amit Khera, Bradley E. Bernstein, Connor A. Emdin, Jesse M. Engreitz, Christian Mueller, Seyedeh M. Zekavat, Robbyn Issner, Russell J.H. Ryan, Catharina R.E. Hilvering, Noam Shoresh, Charles B. Epstein, Jonathan D. Brown, Sekar Kathiresan, Rajat M. Gupta

Publikováno v: Cell, 170(3), 522-533.e15. Elsevier B.V.
Cell, 170(3), 522-533.e15. Cell Press
Cell, 170(3), 522. Cell Press

Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for five vascular diseases, including coronary artery disease, migraine headache, cervical artery dissection, fibromuscular dysplasia, and hypertension. Through geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5854b1c98bf0052edf0cdd381a769d
https://pure.knaw.nl/portal/en/publications/722caf75-591a-4bc8-ac9b-67a211a4909a

Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility

Autor: Eun A. Ko, Harry A. T. Pritchard, Albert L. Gonzales, Scott Earley, Kenton M. Sanders, Grant W. Hennig, Bernard T. Drumm, Paulo W. Pires

Publikováno v: Pritchard, H A T, Gonzales, A L, Pires, P W, Drumm, B T, Ko, E A, Sanders, K M, Hennig, G W & Earley, S 2017, ' Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility ', Science Signaling, vol. 10, no. 497 . https://doi.org/10.1126/scisignal.aan2694

Junctional membrane complexes facilitate excitation-contraction coupling in skeletal and cardiac muscle cells by forming subcellular invaginations that maintain close (≤20 nm) proximity of ryanodine receptors (RyRs) on the sarcoplasmic reticulum (S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa85aa0c541ae7827eac6eeb2496fd34
https://pubmed.ncbi.nlm.nih.gov/28928237

Human induced pluripotent stem cell-derived vascular smooth muscle cells: differentiation and therapeutic potential

Autor: Søren P. Sheikh, Tilde Eskildsen, Sohrab Ayoubi

Publikováno v: Ayoubi, S, Sheikh, S P & Eskildsen, T V 2017, ' Human induced pluripotent stem cell-derived vascular smooth muscle cells : differentiation and therapeutic potential ', Cardiovascular Research, vol. 113, no. 11, pp. 1282-1293 . https://doi.org/10.1093/cvr/cvx125

Cardiovascular diseases remain the leading cause of death worldwide and current treatment strategies have limited effect of disease progression. It would be desirable to have better models to study developmental and pathological processes and model v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b904f3a30e59eddad945e7fccfda05
https://pubmed.ncbi.nlm.nih.gov/28859296