Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Vasavi Sundaram"'
Autor:
Alice Antonello, Riccardo Bergamin, Nicola Calonaci, Jacob Househam, Salvatore Milite, Marc J. Williams, Fabio Anselmi, Alberto d’Onofrio, Vasavi Sundaram, Alona Sosinsky, William C. H. Cross, Giulio Caravagna
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-40 (2024)
Abstract Copy number alterations (CNAs) are among the most important genetic events in cancer, but their detection from sequencing data is challenging because of unknown sample purity, tumor ploidy, and general intra-tumor heterogeneity. Here, we pre
Externí odkaz:
https://doaj.org/article/58afabce18a849ecb410852f49a33e9f
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Although most are silenced, certain transposable elements (TEs) have been co-opted by the host. Here, the authors quantify the epigenomic status of TEs using data from the Roadmap Epigenomics Project, provide a systematic profile of TE activity acros
Externí odkaz:
https://doaj.org/article/9be8243c98f04693903b38c681d2a1b9
Autor:
Wayne A. Warner, Tammy Y. Lee, Kimberly Badal, Tanisha M. Williams, Smriti Bajracharya, Vasavi Sundaram, Nigel A. Bascombe, Ravi Maharaj, Marjorie Lamont-Greene, Allana Roach, Melissa Bondy, Matthew J. Ellis, Timothy R. Rebbeck, Simeon Slovacek, Jingqin Luo, Adetunji T. Toriola, Adana A. M. Llanos
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Cancer is the second leading cause of death in the Caribbean, including the islands of Trinidad and Tobago (TT). The population of TT consists of over 1.3 million people with diverse ancestral and sociocultural backgrounds, both o
Externí odkaz:
https://doaj.org/article/41940c91c9b349779d960cfda4d522f3
Autor:
Vasavi Sundaram, Mayank N. K. Choudhary, Erica Pehrsson, Xiaoyun Xing, Christopher Fiore, Manishi Pandey, Brett Maricque, Methma Udawatta, Duc Ngo, Yujie Chen, Asia Paguntalan, Tammy Ray, Ava Hughes, Barak A. Cohen, Ting Wang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The gene-battery model posits transposable elements (TEs) may becis-regulatory elements to control gene expression. Here, mouse-specific TEs are shown as binding sites for multiple collaborating transcription factors in embryonic stem cells, and act
Externí odkaz:
https://doaj.org/article/9182e1481f7b4fb78384a75c96e24065
Autor:
Oriol Pich, Juliet Luft, Michael Nicholson, Sarah Aitken, Paul Ginno, Vasavi Sundaram, Martin Taylor, Craig Anderson
SummaryDNA base damage is a major source of oncogenic mutations1. Such damage can produce strand-phased mutation patterns and multiallelic variation through the process of lesion segregation2. Here, we exploited these properties to reveal how strand-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32bdd7a1e1d1d95320de70e963634c9f
https://doi.org/10.1101/2022.06.10.495644
https://doi.org/10.1101/2022.06.10.495644
Autor:
Alan Y. Du, Xiaoyu Zhuo, Vasavi Sundaram, Nicholas O. Jensen, Hemangi G. Chaudhari, Nancy L. Saccone, Barak A. Cohen, Ting Wang
Publikováno v:
Genome research. 32(10)
Many transposable elements (TEs) contain transcription factor binding sites and are implicated as potential regulatory elements. However, TEs are rarely functionally tested for regulatory activity, which in turn limits our understanding of how TE reg
Autor:
Alan Y. Du, Xiaoyu Zhuo, Vasavi Sundaram, Nicholas O. Jensen, Hemangi G. Chaudhari, Nancy L. Saccone, Barak A. Cohen, Ting Wang
Many transposable elements (TEs) contain transcription factor binding sites and are implicated as potential regulatory elements. However, TEs are rarely functionally tested for regulatory activity, which in turn limits our understanding of how TE reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db14ea1dcf31868b4879c36a3c04072f
https://doi.org/10.1101/2022.03.16.483999
https://doi.org/10.1101/2022.03.16.483999
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
Transposable elements (TEs) have deposited functional regulatory elements throughout the human genome. Although most are silenced, certain TEs have been co-opted by the host. However, a comprehensive, multidimensional picture of the contribution of T
Computational validation of clonal and subclonal copy number alterations from bulk tumour sequencing
Autor:
Alice Antonello, Riccardo Bergamin, Nicola Calonaci, Jacob Househam, Salvatore Milite, Marc J Williams, Fabio Anselmi, Alberto d’Onofrio, Vasavi Sundaram, Alona Sosinsky, William CH Cross, Giulio Caravagna
Cancer is a global health issue that places enormous demands on healthcare systems. Basic research, the development of targeted treatments, and the utility of DNA sequencing in clinical settings, have been significantly improved with the introduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90bf93d9fcbccdf1f2ea0af71003300a
https://doi.org/10.1101/2021.02.13.429885
https://doi.org/10.1101/2021.02.13.429885
Autor:
Joanna Wysocka, Vasavi Sundaram
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences
Eukaryotic gene regulation is mediated by cis -regulatory elements, which are embedded within the vast non-coding genomic space and recognized by the transcription factors in a sequence- and context-dependent manner. A large proportion of eukaryotic