Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Vasanti S Anand"'
Autor:
Pooja P Pungaliya, Yuchen Bai, Kerri Lipinski, Vasanti S Anand, Saurabh Sen, Eugene L Brown, Brian Bates, Peter H Reinhart, Andrew B West, Warren D Hirst, Steven P Braithwaite
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13672 (2010)
Mutations in LRRK2 (leucine-rich repeat kinase 2) have been identified as major genetic determinants of Parkinson's disease (PD). The most prevalent mutation, G2019S, increases LRRK2's kinase activity, therefore understanding the sites and substrates
Externí odkaz:
https://doaj.org/article/7795cb510d11410bb3354211ec86ecfc
Publikováno v:
FEBS Journal. 276:6428-6435
Leucine-rich repeat kinase 2 (LRRK2) is a large, complex, multidomain protein containing kinase and GTPase enzymatic activities and multiple protein-protein interaction domains. Mutations linked to autosomal dominant forms of Parkinson's disease resu
Autor:
Jacob W. Vogel, John Dunlop, Brian Ludwig, Vasanti S. Anand, Stan P. Nawoschik, Steven P. Braithwaite
Publikováno v:
Neuropharmacology. 57:539-550
Neurofibrillary tangles composed of hyperphosphorylated tau are a major hallmark of Alzheimer's Disease. This phosphorylated tau may be a root cause of the disorder and therefore understanding its regulation is important for therapeutic intervention.
Publikováno v:
Journal of Neuroscience. 28:6757-6759
Parkinson's disease (PD) is a neurological disorder in which degeneration of midbrain dopaminergic neurons leads to severe motor impairment. Neurotransmitter replacement therapy using the dopamine precursor levodopa remains the gold standard symptoma
Autor:
Kerri Lipinski, Pooja Pungaliya, Vasanti S. Anand, Warren D. Hirst, Brian Bates, Peter H. Reinhart, Sercan Sen, Eugene L. Brown, Yuchen Bai, Steven P. Braithwaite, Andrew B. West
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 10, p e13672 (2010)
PLoS ONE, Vol 5, Iss 10, p e13672 (2010)
Mutations in LRRK2 (leucine-rich repeat kinase 2) have been identified as major genetic determinants of Parkinson's disease (PD). The most prevalent mutation, G2019S, increases LRRK2's kinase activity, therefore understanding the sites and substrates
Publikováno v:
The FEBS journal. 276(22)
Leucine-rich repeat kinase 2 (LRRK2) is a large, complex, multidomain protein containing kinase and GTPase enzymatic activities and multiple protein-protein interaction domains. Mutations linked to autosomal dominant forms of Parkinson's disease resu
Autor:
Steven M. Riddle, Eugene L. Brown, Vasanti S. Anand, Richard Somberg, Kerry Kelleher, Pooja Pungaliya, Wayne Stochaj, Warren D. Hirst, Peter H. Reinhart, Steven P. Braithwaite, Weili Duan, Kerri Lipinski, Laurie J. Reichling
Publikováno v:
The FEBS journal. 276(2)
Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the leading cause of autosomal dominant Parkinson's disease, with age of onset and symptoms identical to those of idiopathic forms of the disorder. Several of these pathogenic mutations are t
Autor:
Stan P. Nawoschik, John Dunlop, Beal McIlvain, Steven P. Braithwaite, Jennifer Moore, Vasanti S. Anand, Brian Ludwig
Publikováno v:
Alzheimer's & Dementia. 4