Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Vasanthy Vigneswara"'
Autor:
Lisa J. Hill, Hannah F. Botfield, Ghazala Begum, Omar Qureshi, Vasanthy Vigneswara, Imran Masood, Nicholas M. Barnes, Lars Bruce, Ann Logan
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Fibrotic disease is a major cause of mortality worldwide, with fibrosis arising from prolonged inflammation and aberrant extracellular matrix dynamics. Compromised cellular and tissue repair processes following injury, infection, metabolic d
Externí odkaz:
https://doaj.org/article/2442875be5214f76ad6435f0b821009d
Autor:
Vasanthy Vigneswara, Zubair Ahmed
Publikováno v:
Cells, Vol 9, Iss 5, p 1259 (2020)
Caspase-2 is the most evolutionarily conserved member of the mammalian caspase family and has been implicated in both apoptotic and non-apoptotic signaling pathways, including tumor suppression, cell cycle regulation, and DNA repair. A myriad of sign
Externí odkaz:
https://doaj.org/article/8ec198db02704c69bd6609aaf3f0e04d
Autor:
Mabruka H. Tarhoni, Vasanthy Vigneswara, Marie Smith, Susan Anderson, Peter Wigmore, John E. Lees, David E. Ray, Wayne G. Carter
Publikováno v:
Molecules, Vol 16, Iss 10, Pp 8535-8551 (2011)
Organophosphorus (OP) compounds are a diverse chemical group that includes nerve agents and pesticides. They share a common chemical signature that facilitates their binding and adduction of acetylcholinesterase (AChE) within nerve synapses to induce
Externí odkaz:
https://doaj.org/article/c28efa82d2e24131b7c435f57c783e51
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61442 (2013)
Abnormal α-synuclein aggregates are hallmarks of a number of neurodegenerative diseases. Alpha synuclein and β-synucleins are susceptible to post-translational modification as isoaspartate protein damage, which is regulated in vivo by the action of
Externí odkaz:
https://doaj.org/article/bd4901aa710d4234a1cc6185ab57c939
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53473 (2012)
Severing the axons of retinal ganglion cells (RGC) by crushing the optic nerve (ONC) causes the majority of RGC to degenerate and die, primarily by apoptosis. We showed recently that after ONC in adult rats, caspase-2 activation occurred specifically
Externí odkaz:
https://doaj.org/article/d55ff27b338843a5af2152d1fc03fc98
Publikováno v:
Molecular Neurobiology
Although neurons in the adult mammalian CNS are inherently incapable of regeneration after injury, we previously showed that exogenous delivery of pigment epithelium-derived factor (PEDF), a 50-kDa neurotrophic factor (NTF), promoted adult retinal ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bd235401f3fb66cd435f866585fbae
https://doi.org/10.1007/s12035-019-1614-2
https://doi.org/10.1007/s12035-019-1614-2
Autor:
Imran Masood, Vasanthy Vigneswara, Ghazala Begum, Lisa J Hill, Hannah Botfield, Ann Logan, Omar S. Qureshi, Lars Bruce, Nicholas M. Barnes
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
NPJ Regenerative Medicine
NPJ Regenerative Medicine
Fibrotic disease is a major cause of mortality worldwide, with fibrosis arising from prolonged inflammation and aberrant extracellular matrix dynamics. Compromised cellular and tissue repair processes following injury, infection, metabolic dysfunctio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef07943b9a1b8706822e156ae0fd1273
https://doi.org/10.1038/s41536-020-00110-2
https://doi.org/10.1038/s41536-020-00110-2
Publikováno v:
Stem cells (Dayton, Ohio). 40(11)
Liver transplantation is an effective therapy, but increasing demand for donor organs has led to the use of marginal donor organs with increased complication rates. Mesenchymal stromal cells (MSC) pleiotropically modulate aberrant immune-mediated res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115a195ad91b60dff5e7b2378d5940c3
https://pubmed.ncbi.nlm.nih.gov/35999023
https://pubmed.ncbi.nlm.nih.gov/35999023
Autor:
Cristina Liboni, Marika Crescenzi, Ricardo Sánchez-Rodríguez, Francesco Paolo Russo, Ana Merino, Philip N. Newsome, Martin J. Hoogduijn, Vasanthy Vigneswara, Maurizio Muraca, Antonella Viola, Bianca Calì, Roberta Angioni
Publikováno v:
International Journal of Molecular Sciences, 21(22):8874, 1-14. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8874, p 8874 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8874, p 8874 (2020)
Primary Sclerosing Cholangitis (PSC) is a progressive liver disease for which there is no effective medical therapy. PSC belongs to the family of immune-mediated biliary disorders and it is characterized by persistent biliary inflammation and fibrosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb04f5470d54e332bfb31aa0554ae673
http://hdl.handle.net/11577/3366789
http://hdl.handle.net/11577/3366789
Autor:
Vasanthy Vigneswara, Zubair Ahmed
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 2, Pp 1-17 (2019)
Cell Death and Disease, Vol 10, Iss 2, Pp 1-17 (2019)
Retinal ganglion cells (RGCs) undergo rapid cell death by apoptosis after injury but can be rescued by suppression of caspase-2 (CASP2) using an siRNA to CASP2 (siCASP2). Pigment epithelium-derived factor (PEDF), has neuroprotective and anti-angiogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c94b662d8dae13ec142d7c5bd0d69569
http://europepmc.org/articles/PMC6362048
http://europepmc.org/articles/PMC6362048